Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status ....Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status of Gambusia infestation in Tasmania.Read moreRead less
Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Functional characterisation of contaminant-nanoparticle associations. Nanoparticles present in the environment modify the movement and toxicity of contaminants. This project targets key gaps that hinder the ability to predict the fate and behaviour of environmental contaminants; this will lead to the optimisation of legislative framework and the management/remediation of contaminated sites (for example, mine sites, landfills).
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100141
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
High sensitivity and precision mass spectrometry for tracing Australia's ancient evolution and securing our future groundwater resources. High sensitivity and precision mass spectrometry for tracing Australia’s ancient evolution and securing our future groundwater resources: Micro-sampling thermal ionisation mass spectrometry (TIMS) provides the ability to undertake ultra low-level isotope analysis of earth and environmental samples. Analysis of radiogenic (for example, Neodymium, Strontium and ....High sensitivity and precision mass spectrometry for tracing Australia's ancient evolution and securing our future groundwater resources. High sensitivity and precision mass spectrometry for tracing Australia’s ancient evolution and securing our future groundwater resources: Micro-sampling thermal ionisation mass spectrometry (TIMS) provides the ability to undertake ultra low-level isotope analysis of earth and environmental samples. Analysis of radiogenic (for example, Neodymium, Strontium and Lead) and stable (for example, Boron) isotopes allows researchers to trace the evolution of the Australian continent from its beginnings in the Precambrian through to the impacts of climate change in the Quaternary period (the last 2.6 million years). The proposed micro-sampling TIMS facility will give researchers the opportunity to characterise mineral deposit formation, paleoclimate records and groundwater sources with new levels of accuracy and precision. This will help secure the economic and environmental future of Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100183
Funder
Australian Research Council
Funding Amount
$715,000.00
Summary
An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectr ....An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectroscopy, solid samples. It will enhance capabilities and sample throughput in environmental science, geoscience, biology and cultural heritage research, significantly accelerating the discovery of new ore bodies, improving environmental risk assessment and assisting research in cancer biology.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less