NEU-HORIZONS: The Neuroprotection And Therapeutic Use Of Riluzole For The Prevention Of Oxaliplatin Neurotoxicity Study.
Funder
National Health and Medical Research Council
Funding Amount
$382,402.00
Summary
Colorectal cancer is the second most commonly diagnosed cancer in Australia, with more than 13500 cases recorded annually. Oxaliplatin is an effective chemotherapy for the treatment of colorectal cancer. The major side-effect of oxaliplatin is the development of nerve damage that leads to loss of feeling in the hands and feet and significant disability. The aim of this study is to conduct a trial of a new treatment for oxaliplatin-induced nerve damage.
Nodal Function In Peripheral Neuroinflammatory Disorders: Target Antigens, Functional Significance And Treatment Response
Funder
National Health and Medical Research Council
Funding Amount
$605,172.00
Summary
Inflammatory neuropathies are autoimmune disorders which produce severe disability and represent a costly burden to the healthcare system, but the causes remain unknown. Recent evidence from our team suggests that antibodies against parts of the peripheral nerve at the node of Ranvier are involved. The project aims to identify these specific targets and monitor treatment responsiveness, stabilise nerve function and prevent persistent disability.
Long-term Nerve Damage In Cancer Survivors: Identification Of Risk Factors And Optimal Assessment Strategies
Funder
National Health and Medical Research Council
Funding Amount
$850,172.00
Summary
Nerve damage following chemotherapy treatment leads to early treatment cessation and long-lasting disability, developing with commonly used chemotherapies. There is a critical need to understand the mechanisms, optimize clinical assessment and develop interventions to prevent nerve damage. This project is designed to detect the impact of long-term nerve damage in cancer survivors and develop a risk profile based on clinical, neurophysiological and genetic factors.
SENSORIMOTOR AND AUTONOMIC DYSREGULATION IN HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES
Funder
National Health and Medical Research Council
Funding Amount
$50,406.00
Summary
Specific genetic mutations can lead to widespread changes in the body. Here we are looking at the congenital Hereditary and Sensory Autonomic Neuropathies, the most common of which primarily affects Eastern European Jews. Affected individuals have difficulty walking and controlling their blood pressure, and also have an indifference to pain. This series of experiments aims to increase our understanding of the underlying neurophysiological disturbances.
Predicting Language Skills From Early Auditory Speech Discrimination In Infants With Hearing Loss: Implications For Early Management And Intervention
Funder
National Health and Medical Research Council
Funding Amount
$706,113.00
Summary
Now that newborn hearing checks are available, hearing loss can be picked up soon after birth and hearing aids are fitted shortly after. Although procedures exist for checking that the devices make sounds audible, there is no way to evaluate their effectiveness for supporting a child’s auditory discrimination. This study aims to 1) develop new clinical tools for assessing infants’ auditory discrimination, and 2) determine whether early discrimination predicts spoken language at 3 years of age.
Better vibrations: controlling light with sound in semiconductor chips. Combining new concepts in the theory of nonlinear optics with advanced experiments, this project aims to develop smart waveguides that bind sound and light tightly together. Laser light and sound waves seem worlds apart, but in the right conditions we can make them interact: sound can change the colour of light. Harnessing this control of light in tiny waveguides on semiconductor chips would enable the development of unique ....Better vibrations: controlling light with sound in semiconductor chips. Combining new concepts in the theory of nonlinear optics with advanced experiments, this project aims to develop smart waveguides that bind sound and light tightly together. Laser light and sound waves seem worlds apart, but in the right conditions we can make them interact: sound can change the colour of light. Harnessing this control of light in tiny waveguides on semiconductor chips would enable the development of unique and useful optical devices, but trapping sound in chips is tremendously difficult. By exploiting untapped material properties, the project seeks to break limits on the freedom and strength of interactions between light and sound. Project outcomes may establish a new class of optical chips for optical sensing and analysis in fields from security to communications to the biosciences.Read moreRead less
Putting stimulated Brillouin scattering to work: tailored optical-phononic interactions for on-chip signal processing. Light interacts with sound via a phenomenon called Brillouin scattering, an effect which is of major importance in modern nonlinear optics but is very difficult to control. Our pioneering project will open the door to low power optical devices and other diverse innovations that will support Australia's needs in defence and communications.
Discovery Early Career Researcher Award - Grant ID: DE160100714
Funder
Australian Research Council
Funding Amount
$354,000.00
Summary
Shaping light – new frontiers in big fast data. This project aims to address the need for new technologies to tackle the bandwidth overload. Because of the basic human desire to communicate and interact, our society has an exponentially growing Internet data demand. The data capacity crunch is imminent. Data demand is rapidly approaching the nonlinear Shannon limit which governs the maximum data capacity of single-mode optical fibres. Bandwidth limitations may have severe implications for societ ....Shaping light – new frontiers in big fast data. This project aims to address the need for new technologies to tackle the bandwidth overload. Because of the basic human desire to communicate and interact, our society has an exponentially growing Internet data demand. The data capacity crunch is imminent. Data demand is rapidly approaching the nonlinear Shannon limit which governs the maximum data capacity of single-mode optical fibres. Bandwidth limitations may have severe implications for society and economy. This project aims to develop chip-scale mode-multiplexers based on innovative 3D integrated photonics and combine them with optical gain to shape light for space-division multiplexed optical communication networks. This is designed to break through the data capacity limit that currently prevents growth in Internet data rates.Read moreRead less
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
Photonic Crystals and Microstructured Optical Fibres for Device Applications. Photonic crystals and microstructured optical fibres, which are amongst the most exciting fields of modern optics and photonics, are set to underpin developments in the next generation of ultrahigh-bandwidth communications systems, the functionalities of which will be truly all-optical. This project will bring together of two leading research groups in these areas, enhancing their collaboration, complementing their ex ....Photonic Crystals and Microstructured Optical Fibres for Device Applications. Photonic crystals and microstructured optical fibres, which are amongst the most exciting fields of modern optics and photonics, are set to underpin developments in the next generation of ultrahigh-bandwidth communications systems, the functionalities of which will be truly all-optical. This project will bring together of two leading research groups in these areas, enhancing their collaboration, complementing their expertise, and enabling them to develop new theoretical and computational tools to facilitate device applications. The program will coordinate research over a broad front and bring real benefits to young researchers in both France and Australia.Read moreRead less