Promoting Regrowth Of Nerve Fibres Into The Epidermis During Diabetic Neuropathy By LRP Agonists
Funder
National Health and Medical Research Council
Funding Amount
$427,102.00
Summary
Nerve damage can develop post injury or disease and is often very debilitating, slow to heal and can cause increased pain. Our work aims to examine a new class of molecules that we show can activate selected fat-receptors on nerve cells to guide the growth of regenerating nerves. We will determine how these receptors function with the aim of developing a novel class of therapeutics directed at healing nerve damage.
Oxidative Phosphorylation Regulation And Neuroprotection In Optic Neuropathies
Funder
National Health and Medical Research Council
Funding Amount
$430,231.00
Summary
We have shown clear differences in the mitochodria, cellular organelles that generate energy, between optic atrophy patients who have good vision and those of patients who have poor vision. We believe that these changes represent a compensation mechanisms that preserves mitochondrial energy production and protects optic nerve cells. This study will characterize these differences further with the aim of identfying new treatments for preventing nerve loss and preserving vision.
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The ....Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The focus of the project is the study of thulium doped silica-based fibres for amplification in the 1460 to 1530 nm wavelength region. Read moreRead less
High-performance smart solar powered on-chip capacitive energy storage. High performance and environmentally friendly on-chip power system is the key bottleneck issue limiting the further performance improvement and miniaturisation of ever-increasing portable optoelectronic devices. Building on previous work, including recent breakthroughs of on-chip photonic devices in patterned graphene oxide thin film and the record-breaking nanophotonics solar cells, the project aims to investigate a new con ....High-performance smart solar powered on-chip capacitive energy storage. High performance and environmentally friendly on-chip power system is the key bottleneck issue limiting the further performance improvement and miniaturisation of ever-increasing portable optoelectronic devices. Building on previous work, including recent breakthroughs of on-chip photonic devices in patterned graphene oxide thin film and the record-breaking nanophotonics solar cells, the project aims to investigate a new concept of super-resolution direct laser printing and simultaneous dopant activation of graphene oxide thin films. It is expected that the conceptually new development of the functional graphene oxide film patterning will allow for smart solar-powered on-chip power systems that outperform the state-of-the-art pollution generating batteries.Read moreRead less
Multi-dimensional optical data storage based on nanophotonics - the third generation optical data storage technology. The key-sector in high tech markets has been the photonics industry over the last decade, and it will continue to revolutionise our ways of information storage, processing and transfer for the next 10 to 20 years. The current project of high-capacity Petabyte optical data storage, i.e the third generation optical data storage, will prove to be the key technological innovation in ....Multi-dimensional optical data storage based on nanophotonics - the third generation optical data storage technology. The key-sector in high tech markets has been the photonics industry over the last decade, and it will continue to revolutionise our ways of information storage, processing and transfer for the next 10 to 20 years. The current project of high-capacity Petabyte optical data storage, i.e the third generation optical data storage, will prove to be the key technological innovation in photonics (one of the National Research Priorities), which will not only meet the growing demands of the consumer market, but also continue to drive the industry and create new markets. This is in line with the Priority Goals set by the Minister for Education, Science and Training, as it will put Australia into the unique position in the information age. Read moreRead less
Nano-photonic fabrication and storage using near-field super-resolving probes. The aim of the project is to develop a novel near-field storage device and nano-fabrication instruments, which are based on the super-resolution technique. As a result, the new storage device has a density 100 times of the current DVD technology. The nano-fabrication techniques can be used for all optics devices of nanometer resolution for fast information transferring. This project extends the key developments in t ....Nano-photonic fabrication and storage using near-field super-resolving probes. The aim of the project is to develop a novel near-field storage device and nano-fabrication instruments, which are based on the super-resolution technique. As a result, the new storage device has a density 100 times of the current DVD technology. The nano-fabrication techniques can be used for all optics devices of nanometer resolution for fast information transferring. This project extends the key developments in the field of nano-photonics and will put Australia in a uniquely strong position in the internationally competitive information technology field.Read moreRead less
Development of three-dimensional high-density optical data storage and photonic crystals in photo-polymers with a superresolution imaging system. The aim of this project is to develop a three-dimensional (3-D) high-density optical data storage method and photonic crystals in photo-polymers using a superresolution imaging system. As a result, it is possible to produce a 3-D data density of approximately 10 Tbits/cm3 in low-cost and erasable photo-polymers, equivalent to 3000 times the information ....Development of three-dimensional high-density optical data storage and photonic crystals in photo-polymers with a superresolution imaging system. The aim of this project is to develop a three-dimensional (3-D) high-density optical data storage method and photonic crystals in photo-polymers using a superresolution imaging system. As a result, it is possible to produce a 3-D data density of approximately 10 Tbits/cm3 in low-cost and erasable photo-polymers, equivalent to 3000 times the information in a current digital video disc (DVD). 3-D polymer-based photonic crystals will provide fast, low-cost and compact all-optics devices for optical computing technology. Consequently, the capacity and speed of information super-highways will be significantly increased, which enhances the internationally competitive ability of Australia in information technology.Read moreRead less
Nanophotonic metamaterials as anti-counterfeit devices in Australian banknotes. This project will demonstrate the application of novel materials as the basis for next generation security features on banknotes. Such elements play a key role in maintaining the integrity of Australia's currency since they present a significant barrier to counterfeiting.
A versatile optical wavelength and mode switching device for future telecommunication networks. This project will develop a next generation switching device for future fibre optical communication networks that will divide their information among several modes of specialty fibre. This device will be a key component for allowing network operators to move to these novel mode-multiplexed networks in order to overcome the looming capacity crunch.