An Inside-out Approach To Muscosal Vaccination: MAdCAM Targeting
Funder
National Health and Medical Research Council
Funding Amount
$174,250.00
Summary
The mucosal surfaces are the entry site for many pathogens (eg. cholera, rotaviruses, helicobacter, SARS and sexually transmitted diseases including HIV infections). The ideal vaccine would elicit both systemic and mucosal immune response, enhancing immunity at this first line of defence. The oral route has formidable barriers to antigen uptake such as digestive enzymes, commensal microbes, mucous layers and gastric acid. Our strategy targets the vascular addressin found in immune tissues of the ....The mucosal surfaces are the entry site for many pathogens (eg. cholera, rotaviruses, helicobacter, SARS and sexually transmitted diseases including HIV infections). The ideal vaccine would elicit both systemic and mucosal immune response, enhancing immunity at this first line of defence. The oral route has formidable barriers to antigen uptake such as digestive enzymes, commensal microbes, mucous layers and gastric acid. Our strategy targets the vascular addressin found in immune tissues of the gut (called MAdCAM) so that the vaccine is linked to an antibody against MAdCAM. Thus for the first time we believe that a parenteral vaccine ie. injected im or iv (bypassing the oral barriers) can induce mucosal immunity.Read moreRead less
The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, ....The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, and targeted epidemiology and disease modelling vaccine preventable disease will also allow a broad program of research, enabling training and mentoring of young clinical nurse and physician researchers. Collaborations with existing national immunisation, infectious diseases and research institutions will allow maximal effectiveness of clinical studies.Read moreRead less
Population Health Planning For Rural Medicare Locals: Evaluating A Community Participation Method For Delivering Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$438,587.00
Summary
The study, in six communities, will evaluate whether an evidenced based method of rural community participation from the UK translates to assist healthcare planning by Medicare Locals. Medicare Locals must involve local people in designing services to improve health, but lack methods to do this. The focus of the study is oral health, a major issue in rural areas. The study evaluates whether new services are designed and implemented and whether there is change to health knowledge and behaviours.
New methodologies for representing and accessing resources on endangered languages: a case study from South Efate. Linguists produce material which has immense cultural significance as it is often the only record of endangered cultures. With new technologies come new ways of working with indigenous languages. This APD will develop an innovative methodology for documenting and archiving data from a language of the Pacific. It will do this by linking a dictionary, texts, audio, video, images and a ....New methodologies for representing and accessing resources on endangered languages: a case study from South Efate. Linguists produce material which has immense cultural significance as it is often the only record of endangered cultures. With new technologies come new ways of working with indigenous languages. This APD will develop an innovative methodology for documenting and archiving data from a language of the Pacific. It will do this by linking a dictionary, texts, audio, video, images and a grammar to facilitate presentation of both the data and its analysis to speakers, fellow linguists, and the general public. The methodology developed in this APD will result in innovative linguistic data management techniques conformant to emerging international standards.Read moreRead less
Oral Tradition, Literacy and Education in Two Eastern Indonesian Societies. This project will improve our understanding of social and cultural change in eastern Indonesia, a region of strategic importance to Australia. The research will contribute significantly to knowledge of the educational system and literacy levels in eastern Indonesia. This knowledge will be of practical use in development projects in the region and to policy makers in Canberra who are concerned with Indonesian affairs. The ....Oral Tradition, Literacy and Education in Two Eastern Indonesian Societies. This project will improve our understanding of social and cultural change in eastern Indonesia, a region of strategic importance to Australia. The research will contribute significantly to knowledge of the educational system and literacy levels in eastern Indonesia. This knowledge will be of practical use in development projects in the region and to policy makers in Canberra who are concerned with Indonesian affairs. The involvement of a PhD student in the project will increase our national research capacity in eastern Indonesia. The contributions to anthropological theory and method this research will produce will enhance Australia's international reputation as a centre of anthropology, southeast Asian studies and the study of literacy.Read moreRead less