Hepatitis B Virus Drug Resistance: Impact On The Immunisation Program
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
ñAntiviral drug-associated vaccine escape mutantsî have the potential to jeopardize the hepatitis B immunization program. Which particular viral mutations or combination of mutations that can directly affect the clinical outcome of infection, especially in the context of vaccine induced immunity, are not known. In this study we will identify the clinical sequelae and public health consequences arising from the selection of these mutants.
Virulence Determinants Of Encephalitic Flaviviruses
Funder
National Health and Medical Research Council
Funding Amount
$455,670.00
Summary
Murray Valley encephalitis, Japanese enecephaltis virus and West Nile virus are mosquito transmitted pathogens that cause severe and fatal neurological diseases in man and animals. Currenly, it is not clear why these viruses produce such severe diseases and therefore they are difficult to treat and prevent. In this project we will indentify the components of the viruses that allow them to invade the central nervous sytem and cause neurological symptoms. This will provide valuable information on ....Murray Valley encephalitis, Japanese enecephaltis virus and West Nile virus are mosquito transmitted pathogens that cause severe and fatal neurological diseases in man and animals. Currenly, it is not clear why these viruses produce such severe diseases and therefore they are difficult to treat and prevent. In this project we will indentify the components of the viruses that allow them to invade the central nervous sytem and cause neurological symptoms. This will provide valuable information on critical elements of these pathogenic viruses that contribute to their virulence and will identify new candidate vaccines for prevention of the encephalitic diseases they cause.Read moreRead less
A Novel Vaccine Platform For Trimeric Envelope Proteins: HIV-1 Envelope
Funder
National Health and Medical Research Council
Funding Amount
$139,250.00
Summary
Vaccines are urgently needed for the prevention of HIV/AIDS. The design of this vaccine candidate is based on the display of HIV-1 envelope spikes using a related primate retrovirus envelope with a more stable assembly to anchor the the spikes in a particle.
Oral Human Papillomavirus Infection In Head And Neck Cancers And The General Population.
Funder
National Health and Medical Research Council
Funding Amount
$422,800.00
Summary
Mucosal cancers of the head and neck are the sixth most common type of cancer worldwide and are increasing in Australia. Human papillomaviruses (HPV), which are the major cause of cervical cancer and the cause of 5% of all human cancers, have recently also been implicated as a cause of some types of head and neck cancer, especially in patients younger than 50 years. In this project we will investigate how HPV infection regulates the expression of key genes in cancers of the head and neck, and ho ....Mucosal cancers of the head and neck are the sixth most common type of cancer worldwide and are increasing in Australia. Human papillomaviruses (HPV), which are the major cause of cervical cancer and the cause of 5% of all human cancers, have recently also been implicated as a cause of some types of head and neck cancer, especially in patients younger than 50 years. In this project we will investigate how HPV infection regulates the expression of key genes in cancers of the head and neck, and how that affects prognosis of this disease.Read moreRead less