A New Synthesis of Steroid Conjugates for Illicit Drug Detection. The prevention of drug abuse in horse racing is vital to preserve the large contribution to employment, Government revenue and to economic activity provided by the Racing Industry. This collaboration aims to develop new highly sensitive analytical procedures for the detection of performance enhancing drugs in horses. The project will develop novel chemistry for the production of standard compounds that are essential for this testi ....A New Synthesis of Steroid Conjugates for Illicit Drug Detection. The prevention of drug abuse in horse racing is vital to preserve the large contribution to employment, Government revenue and to economic activity provided by the Racing Industry. This collaboration aims to develop new highly sensitive analytical procedures for the detection of performance enhancing drugs in horses. The project will develop novel chemistry for the production of standard compounds that are essential for this testing program and are currently unavailable by other means. The methods developed will have wider application to the testing of drugs in athletes and the detection of recreational drugs.Read moreRead less
Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of ....Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of this project will be the introduction of robust methods of analysis for potential drug abuse in greyhound racing that will position Australia as a world leader in the field.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100677
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Deconstructing molecular self-assembly by advanced mass spectrometry. This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential o ....Deconstructing molecular self-assembly by advanced mass spectrometry. This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential of self-assembly to fabricate highly functional materials. This project expects to determine the critical link between the assemblies’ structure and function, and provide the rational framework to optimise and direct synthetic outcomes. This could enable Australian manufacturers to create low-energy production processes of high value commodities.Read moreRead less
The photons take charge: Elucidating the structure and stability of distonic radical anions by mass spectrometry and photoelectron spectroscopy. Recent work has discovered that certain radical anions have electronic configurations that defy chemical convention and exhibit exceptional radical stability. Exploitation of this breakthrough first requires experimental elucidation of the intrinsic electronic structure of these compounds and how it relates to their remarkable properties. This project w ....The photons take charge: Elucidating the structure and stability of distonic radical anions by mass spectrometry and photoelectron spectroscopy. Recent work has discovered that certain radical anions have electronic configurations that defy chemical convention and exhibit exceptional radical stability. Exploitation of this breakthrough first requires experimental elucidation of the intrinsic electronic structure of these compounds and how it relates to their remarkable properties. This project will probe the fundamental structure and energetics of radical anions by modifying instrumentation to enable multi-step gas-phase ion synthesis to be efficiently coupled with anion photoelectron spectroscopy. These investigations are essential to revealing the scope of this phenomenon in free radical chemistry and biology and could inform future development of new catalysts for polymerisation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100145
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Three-dimensional analysis of important organic components in energy, environmental and earth systems. Australia’s ecosystems and water resources are sensitive to climate change and anthropogenic activities. A third degree of separation provided by this technique will improve our abilities to monitor the role of organic matter in modern systems. The characterisation of organics of petroleum mineral systems will sustain Australia's energy demand.
Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The in ....Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.
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Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is signi ....Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100050
Funder
Australian Research Council
Funding Amount
$744,100.00
Summary
New South Wales molecular analysis platform: Fourier transform ion cyclotron resonance mass spectrometer and CHN&S analyser. This project aims to provide critical infrastructure for research in the molecular sciences by providing state of the art mass spectrometry and elemental analysis instrumentation. The project will support research for over 100 groups in New South Wales (NSW) and will lead to new knowledge in a variety of areas. Expected outcomes include enhanced capacity and productivity, ....New South Wales molecular analysis platform: Fourier transform ion cyclotron resonance mass spectrometer and CHN&S analyser. This project aims to provide critical infrastructure for research in the molecular sciences by providing state of the art mass spectrometry and elemental analysis instrumentation. The project will support research for over 100 groups in New South Wales (NSW) and will lead to new knowledge in a variety of areas. Expected outcomes include enhanced capacity and productivity, new interdisciplinary collaborations and the discovery of novel materials and bioactive molecules, leading to wealth creation. The significant benefits of the NSW molecular analysis platform will include the ability to rapidly analyse molecules with the highest certainty, and will enhance the impact of Australian research via access to new technologies.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100020
Funder
Australian Research Council
Funding Amount
$3,279,502.00
Summary
ARC Training Centre for the Chemical Industries . The ARC Training Centre for the Chemical Industries will foster a world-class environment of transformative innovative research in Australia’s chemical and advanced manufacturing industry through sustained partnerships with universities. The Centre establish a new industry-led HDR graduate program. The research activities of the Centre aim to improve chemical analytical and manufacturing capabilities, new biopharmaceuticals, enhanced global compe ....ARC Training Centre for the Chemical Industries . The ARC Training Centre for the Chemical Industries will foster a world-class environment of transformative innovative research in Australia’s chemical and advanced manufacturing industry through sustained partnerships with universities. The Centre establish a new industry-led HDR graduate program. The research activities of the Centre aim to improve chemical analytical and manufacturing capabilities, new biopharmaceuticals, enhanced global competitive advantages, and long-term growth and intellectual property development in the chemistry industry. Other national benefits include up-skilled, workplace-ready graduates with experience in conducting industry-focused research.Read moreRead less