The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon ....The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon these successes, in order to develop innovative analytical strategies for forensic detection of certain illicit drugs and explosives. The results of this research have the potential to revolutionise key aspects of forensic analysis.Read moreRead less
Immobilised Lipid Chromatography for Membrane Protein Isolation and Analysis. Current techniques for membrane protein are inadequate for the emerging proteomic challenge, in which approximately 40% of proteins are predicted to be membrane associated. The aim of this proposal is to develop a new approach to purify membrane proteins using our recently-developed immobilised membrane chromatography materials. The present proposal will provide a new high-resolution separation technique that allows is ....Immobilised Lipid Chromatography for Membrane Protein Isolation and Analysis. Current techniques for membrane protein are inadequate for the emerging proteomic challenge, in which approximately 40% of proteins are predicted to be membrane associated. The aim of this proposal is to develop a new approach to purify membrane proteins using our recently-developed immobilised membrane chromatography materials. The present proposal will provide a new high-resolution separation technique that allows isolation and on-line mass analysis of complex mixtures of membrane proteins for subsequent proteomic analysis, high-throughput screening or structural studies and could form the basis for further development of new commercial tools for membrane protein analysis.Read moreRead less
Marine oil seeps and airborne particulates characterisation for organic compositional fingerprinting by using novel gas chromatographic technologies. Comprehensive two-dimensional gas chromatography (GCxGC) is a powerful new tool for studying complex organic materials. The technique provides a highly sensitive method of fingerprinting not only the composition of the material but also its environmental history and behaviour. In this project the technique will be applied to a range of petroleum- ....Marine oil seeps and airborne particulates characterisation for organic compositional fingerprinting by using novel gas chromatographic technologies. Comprehensive two-dimensional gas chromatography (GCxGC) is a powerful new tool for studying complex organic materials. The technique provides a highly sensitive method of fingerprinting not only the composition of the material but also its environmental history and behaviour. In this project the technique will be applied to a range of petroleum-related organic samples, including oil seeps from the ocean floor, and airborne particulates contributing to air pollution. The research will lead to a better understanding of geochemistry of petroleum-related materials and their potential impact on the environment and on public health.Read moreRead less
New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicompon ....New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882836
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
A novel isotope facility to characterise high-molecular-weight fractions of natural organic matter in soils, sediments, water, petroleum and coal. This facility will improve our ability to forecast environmental responses to future climate change, and help Australia manage current threats to its biodiversity. Furthermore, this research will increase the ability to identify crude oil sources, to the benefit of petroleum exploration in Australia. This facility will also contribute to an improved u ....A novel isotope facility to characterise high-molecular-weight fractions of natural organic matter in soils, sediments, water, petroleum and coal. This facility will improve our ability to forecast environmental responses to future climate change, and help Australia manage current threats to its biodiversity. Furthermore, this research will increase the ability to identify crude oil sources, to the benefit of petroleum exploration in Australia. This facility will also contribute to an improved understanding of controls on water quality and will help to protect our precious freshwater resources, already under intense pressure from climate change. Importantly, this project will enable students and young professionals to be trained in state-of-the-art technology, leading to quality scientists ready for employment in industry.
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Oxidation product generation during heating and storage of bio-fuels and alternative fuels assessed by multidimensional gas chromatography. Renewable bio-fuels offer much promise as a replacement for fossil fuels. However, they have a tendency to oxidise when prepared and used, potentially forming gums and solid deposits in engines. The objective of this project is the identification of these deposits and subsequent prevention during engine operation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100127
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
High resolution liquid chromatography mass spectrometry (Orbitrap) for analyses of polar compounds in biomass, petroleum, potable and reclaimed water. Climate change and human impact can harm sensitive ecosystems, significantly threatening Australian biodiversity and water resources. Chemical and biological characterisation of aquatic and terrestrial environments is paramount to assessing and responding to these threats, as well as assisting natural resource utilisation. The high structural pola ....High resolution liquid chromatography mass spectrometry (Orbitrap) for analyses of polar compounds in biomass, petroleum, potable and reclaimed water. Climate change and human impact can harm sensitive ecosystems, significantly threatening Australian biodiversity and water resources. Chemical and biological characterisation of aquatic and terrestrial environments is paramount to assessing and responding to these threats, as well as assisting natural resource utilisation. The high structural polarity of many environmentally occurring organics from biological, petroleum and anthropogenic sources, unamenable to gas chromatographic resolution, can now be accommodated by the advanced organic analytical technology sought in this proposal. This project will enable scholars and young professionals to be skilled in state-of-the-art technology, and prepare quality scientists, ready for employment.Read moreRead less