Metal catalysed reactions in organic synthesis. The major aim of this project is to develop highly efficient metal-catalysed routes to pharmaceuticals, e.g. new antibiotics and other commercially important organic molecules.
Particular attention will be paid to developing systems which facilitate the addition of readily available, cheap small molecules, e.g. hydrogen and carbon monoxide, to unsaturated organic molecules with high regio- and stereoselectivity.
Worldwide demand for enantiomeric ....Metal catalysed reactions in organic synthesis. The major aim of this project is to develop highly efficient metal-catalysed routes to pharmaceuticals, e.g. new antibiotics and other commercially important organic molecules.
Particular attention will be paid to developing systems which facilitate the addition of readily available, cheap small molecules, e.g. hydrogen and carbon monoxide, to unsaturated organic molecules with high regio- and stereoselectivity.
Worldwide demand for enantiomerically pure chiral molecules (i.e. one mirror-image form) continues to rise. New metal-catalysed asymmetric syntheses will help meet this challenge. Tandem metal-catalysed reactions will be used to prepare new heterocyclic compounds with potential as specific metal binding agents and biosensors.Read moreRead less
Biomimetic and Methodology Based Total Synthesis of Bioactive Natural Products. The proposal will study the synthesis of novel natural products that possess biological activities. Most significantly, this project will deliver compounds with anticancer activity. In addition, chemistry may be developed which could be utilised to synthesise a number of bioactive molecules. The rewards of the synthesis of compounds and application for the treatment of cancer and other diseases are enormous for the ....Biomimetic and Methodology Based Total Synthesis of Bioactive Natural Products. The proposal will study the synthesis of novel natural products that possess biological activities. Most significantly, this project will deliver compounds with anticancer activity. In addition, chemistry may be developed which could be utilised to synthesise a number of bioactive molecules. The rewards of the synthesis of compounds and application for the treatment of cancer and other diseases are enormous for the community and in the education and training of scientists.Read moreRead less
Total Synthesis of Novel Metabolites form Microorganisms. The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal meta ....Total Synthesis of Novel Metabolites form Microorganisms. The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal metabolite zaragozic acid C.
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Synthesis of Bioactive Metabolites from Myxobacteria. The crocacins and apicularens are two diverse groups of biologically active molecules isolated from myxobacteria. Crocacins A-D are dipeptides which show antifungal activity and are highly cytostatic in mammalian cell cultures. The novel macrolide apicularen A is highly active against a number of human tumour cell lines and shows promise as a new type of anticancer compound. The aim of this project is develop a methodology to synthesise these ....Synthesis of Bioactive Metabolites from Myxobacteria. The crocacins and apicularens are two diverse groups of biologically active molecules isolated from myxobacteria. Crocacins A-D are dipeptides which show antifungal activity and are highly cytostatic in mammalian cell cultures. The novel macrolide apicularen A is highly active against a number of human tumour cell lines and shows promise as a new type of anticancer compound. The aim of this project is develop a methodology to synthesise these novel compounds.Read moreRead less
New synthetic strategies to small cyclic peptides. This project aims to invent new synthetic strategies that enable chemical manipulation of small cyclic peptides, a promising class of biologically active molecules with high metabolic stability. Combining theory and practice, this project will develop novel acyl transfer reactions that will allow traceless, site-selective, ring expansion and contraction of small cyclic peptides. This project will result in new synthetic methodology that will sim ....New synthetic strategies to small cyclic peptides. This project aims to invent new synthetic strategies that enable chemical manipulation of small cyclic peptides, a promising class of biologically active molecules with high metabolic stability. Combining theory and practice, this project will develop novel acyl transfer reactions that will allow traceless, site-selective, ring expansion and contraction of small cyclic peptides. This project will result in new synthetic methodology that will simplify the synthesis of an important class of small drug-like molecules. This will provide significant benefits, such as a breakthrough in the synthetic approach to small cyclic peptides, which will strengthen Australia’s international standing in peptide research and provide new strategies for translation to the growing biotechnology industry.Read moreRead less
AI Assisted Continuous Flow Electrochemistry for Pharmaceutical Manufacture. This project aims to develop new chemical manufacturing processes for pharmaceutical products. In collaboration with Sun Pharma, it will tackle the challenge of replacing expensive and toxic chemicals in industrial reactions, to lower cost of manufacturing and improve its sustainability profile. Central to the realisation of this ambition is the use of electrocatalysis, machine learning and implementation of advanced co ....AI Assisted Continuous Flow Electrochemistry for Pharmaceutical Manufacture. This project aims to develop new chemical manufacturing processes for pharmaceutical products. In collaboration with Sun Pharma, it will tackle the challenge of replacing expensive and toxic chemicals in industrial reactions, to lower cost of manufacturing and improve its sustainability profile. Central to the realisation of this ambition is the use of electrocatalysis, machine learning and implementation of advanced continuous flow methods. These electricity- and technology-driven reactions will develop new strategies for the generation of important classes of molecules relevant to the Australia’s pharmaceutical sector, as well as their manufacture at industrially relevant scales.Read moreRead less
Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve imp ....Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve important problems in organic chemistry that have been unresolved for decades, and synthesise valuable chemicals normally generated using expensive precious metal catalysts.Read moreRead less
Novel organic materials for efficient low-cost solar cells. Finding sources of renewable energy is the greatest challenge faced by mankind in the coming decades. Solar energy has the potential to provide a large fraction of the world's energy needs. The successful development of a solar technology capable of large scale energy production will reduce our dependence on non-renewable energy sources, such as fossil fuels, leading to the reduction of greenhouse gas emissions and a sustainable envir ....Novel organic materials for efficient low-cost solar cells. Finding sources of renewable energy is the greatest challenge faced by mankind in the coming decades. Solar energy has the potential to provide a large fraction of the world's energy needs. The successful development of a solar technology capable of large scale energy production will reduce our dependence on non-renewable energy sources, such as fossil fuels, leading to the reduction of greenhouse gas emissions and a sustainable environment. The harnessing of solar energy involves a number of frontier technologies that will enhance Australia's strengths in research and innovation. There is also potential for the creation of a world-class industry in solar energy that has both economic and environmental benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101548
Funder
Australian Research Council
Funding Amount
$373,052.00
Summary
Enantioselective catalysis using P-chiral phosphines and phosphinamines. This project aims to develop new methods to synthesise organic molecules. The synthesis of organic molecules for medicines, polymers and other applications depends on the use of catalysts to promote chemical reactions. The use of small organic catalysts, rather than those based on transition metals or enzymes, offers many advantages in the form of low toxicity, low cost, ease of use and minimal environmental impact. This pr ....Enantioselective catalysis using P-chiral phosphines and phosphinamines. This project aims to develop new methods to synthesise organic molecules. The synthesis of organic molecules for medicines, polymers and other applications depends on the use of catalysts to promote chemical reactions. The use of small organic catalysts, rather than those based on transition metals or enzymes, offers many advantages in the form of low toxicity, low cost, ease of use and minimal environmental impact. This project aims to deliver new methods for synthesis using new approaches in organocatalysis. The methods will be used to synthesise important molecules, including novel catalysts, biocompatible polyester materials and chiral phosphines, which are widely used in chemical industry but difficult and expensive to produce.Read moreRead less
Atmospheric Free-Radicals: Exploring the Role of Nitrate Radicals in the Oxidative Damage of Bio-Surfaces. This project falls within the National Research Priority 2 (Promoting and Maintaining Good Health) as identified by the ARC, specifically Priority Goal 2 (Ageing well, ageing productively) and Priority Goal 3 (Preventive healthcare). The study will lead to a better understanding of environmental factors influencing health and welfare of Australians every age and will provide unique opport ....Atmospheric Free-Radicals: Exploring the Role of Nitrate Radicals in the Oxidative Damage of Bio-Surfaces. This project falls within the National Research Priority 2 (Promoting and Maintaining Good Health) as identified by the ARC, specifically Priority Goal 2 (Ageing well, ageing productively) and Priority Goal 3 (Preventive healthcare). The study will lead to a better understanding of environmental factors influencing health and welfare of Australians every age and will provide unique opportunities for students to be trained in cutting-edge basic research. Knowledge and fundamental understanding of the damage of bio-surfaces caused by atmospheric free-radical oxidants and their potential role in ageing processes will help to develop novel medical strategies, which substantially contribute to the quality of Australian sciences.Read moreRead less