Enhancing The Cascade Of HIV Care To Maximise The Prevention Benefits Of Antiretroviral Therapy For Populations Living With HIV
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
Antiretroviral drugs are effective at preventing death and illness for populations with HIV and preventing HIV transmission. I will undertake a series of studies to measure the impact of current antiretroviral treatment to prevent both illness and new infections in Australia. I will also undertake a series of studies to increase HIV testing, diagnose HIV earlier, and improve people’s linkage and retention HIV in care and evaluate the impact of these interventions on HIV transmission.
Community Treatment Intervention With Ivermectin To Reduce The Prevalence Of Scabies And Strongyloides
Funder
National Health and Medical Research Council
Funding Amount
$109,046.00
Summary
Scabies and strongyloides are endemic in many remote East Arnhem Aboriginal communities. To reduce the prevalence of these parasitic infections a community treatment intervention will be undertaken using the drug Ivermectin. The introduction of this innovative drug treatment regime for both scabies and strongyloides will be a first in Australia.
Treatment And Prevention Of HIV And Sexually Transmitted Infections
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
My research will use statistical and mathematical models to answer questions in the prevention and treatment of infectious diseases. I will assess long-term outcomes in HIV positive patients, including developing risk prediction models to improve patients monitoring. I will look at strategies to improve antiretroviral treatment in developing countries in Asia. And I will identify optimal preventions strategies to reduce rates of sexually transmitted infections.
Next Generation Sequencing Of Hepatitis C Virus To Detect Drug Resistance Mutations
Funder
National Health and Medical Research Council
Funding Amount
$39,497.00
Summary
Hepatitis C is the leading cause of liver cancer and liver failure requiring transplantation in Australia. New antiviral drugs set to revolutionise hepatitis C treatment by substantially improving cure rates could be challenged by the development of resistance mutations, which would make these drugs less effective. We aim to develop a practical test to be used routinely to guide clinicians in choosing appropriate anti-viral drugs for their patients.
A Safety, Tolerability, Pharmacokinetic And Efficacy Study Of Azithromycin Plus Piperaquine As Intermittent Presumptive Treatment In Pregnant Papua New Guinean Women
Funder
National Health and Medical Research Council
Funding Amount
$345,684.00
Summary
The purpose of this research is to investigate a new antimalarial combination therapy, azithromycin (AZI) plus piperaquine (PQ), for the prevention of malaria infection in pregnant Papua New Guinean women. It is anticipated that these studies will provide sufficient data to determine if AZI-PQ is a suitable alternative treatment option in PNG, and other countries which have similar malaria epidemiology including the presence of drug resistant parasites.
Understanding, Detecting, Monitoring And Treating Brain Dysfunctions Due To Chronic Immune Diseases
Funder
National Health and Medical Research Council
Funding Amount
$415,219.00
Summary
The role of immune burdens on the brain of middle-aged persons is not well understood. For example the combined brain effects of HIV and cardio-vascular diseases are unknown. Our research is about better understanding those processes using advanced neuropsychology and brain imaging methods. It is also about developing new instruments to detect problems as early as possible, to monitor them accurately and to better treat them in Australia and the Asia-Pacific region.
A Study Of Factors That May Influence The Neurocognitive Health Of HIV+ Populations: For Better- Early Antiretroviral Therapy? For Worse- Cardiovascular Risk Factors And Disease?
Funder
National Health and Medical Research Council
Funding Amount
$362,123.00
Summary
Cognitive health is of primary importance to HIV affected communities. Recently high blood pressure and high cholesterol have been associated with poor cognitive performance in middle aged HIV+ patients. We plan to study whether HIV+ patients with cardiovascular risk factors have faster and more frequent cognitive decline than HIV+ and HIV- patients without these risk factors. In another study we plan to determine the potential benefits of early versus deferred HIV antiretroviral therapy upon ne ....Cognitive health is of primary importance to HIV affected communities. Recently high blood pressure and high cholesterol have been associated with poor cognitive performance in middle aged HIV+ patients. We plan to study whether HIV+ patients with cardiovascular risk factors have faster and more frequent cognitive decline than HIV+ and HIV- patients without these risk factors. In another study we plan to determine the potential benefits of early versus deferred HIV antiretroviral therapy upon neurocognitive performance.Read moreRead less
Understanding And Preventing Chronic Disease In People Living With HIV
Funder
National Health and Medical Research Council
Funding Amount
$367,946.00
Summary
Australia’s ageing population is increasingly at risk of chronic diseases such as heart disease and diabetes. For Australians who are living with HIV, these diseases occur more frequently and at an earlier age. I will be investigating the underlying reasons for this increase in risk and will test innovative online systems that help people living with HIV reduce their risk of chronic disease. This work will provide important information for Australians at risk of developing chronic disease.