The Role Of Primordial Follicle Activation In Premature Ovarian Failure
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
As women age, both the quality and quantity of their eggs decline and their chances of conceiving plummets. Premature ovarian failure (POF) is a disease of infertility, diagnosed in 3% of all women, defined by the early onset of menopause before age 40. Our poor understanding of the factors that regulate female egg supply remains a major limitation in treating POF. I will study key factors responsible for controlling egg number, with practical implications for POF diagnosis and treatment.
Polycystic ovary syndrome (PCOS) affects a striking 9-21% of women of reproductive age. PCOS is an important health problem and can affect menstrual cycles, fertility and increase risk of diabetes and mood disorders. There is a lack of longitudinal studies that women with PCOS over time to examine the key determinants of PCOS, long-term impact of obesity and factors contributing to PCOS complications.
Weight Gain Prevention In Women With Polycystic Ovary Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Obesity increases polycystic ovary syndrome (PCOS) prevalence and severity across metabolic, reproductive and psychological features. Weight management is the recommended first-line PCOS treatment and women with PCOS are at high risk of weight gain, but weight gain prevention program has not been trialled in this group. This study will assess the effect of metformin, a commonly prescribed drug for PCOS, and a low-intensity lifestyle program on weight gain women with PCOS.
Improving Pregnancy Care For Populations At Risk In Australia
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Pregnancy provides an opportunity to improve short and long-term health of both women and babies. Provision of high-quality, appropriate pregnancy care is a vital step in reducing health disparities in Australia. I will conduct public health research that improves pregnancy care for three populations of women at risk of poor health before and during pregnancy: women of refugee background, Aboriginal and Torres Strait Islander women and women with polycystic ovary syndrome.
The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.