Atherosclerosis:Lipoproteins, Cell Biology And Vascular Physiology
Funder
National Health and Medical Research Council
Funding Amount
$7,274,391.00
Summary
The team comprises internationally recognised experts in basic, clinical and public health applied research in cardiovascular disease, particularly atherosclerosis that is the commonest cause of death in Australia and other developed countries. Over the last decade, improvement in cardiovascular health has been primarily the result of a better understanding on how to control 'bad' (or LDL) cholesterol. The significance of the proposed studies is that, on the one hand, they will provide new infor ....The team comprises internationally recognised experts in basic, clinical and public health applied research in cardiovascular disease, particularly atherosclerosis that is the commonest cause of death in Australia and other developed countries. Over the last decade, improvement in cardiovascular health has been primarily the result of a better understanding on how to control 'bad' (or LDL) cholesterol. The significance of the proposed studies is that, on the one hand, they will provide new information on how 'good' lipoproteins protect us from atherosclerosis. This information can then be used to regulate 'good' cholesterol in a meaningful manner. On the other hand, the proposed studies will provide fundamental insights into how a range of lifestyle factors, physiological processes and pathological conditions relate to both the function of blood vessel-lining cells and susceptibility of individuals to atherosclerosis.Read moreRead less
Insult, Injury And Recovery In Brain Disease: From Molecules To Therapeutic Outcome
Funder
National Health and Medical Research Council
Funding Amount
$8,215,611.00
Summary
When nerve cells are damaged, destroyed or injured, through disease or trauma, common pathological processes are set in train. Even though there are many factors that might trigger disease, these inevitably lead to common processes that end in cell death or initiate protective processes. One theme involves the factors that surround these responses to nerve injury and stress, and the consequent protective and regenerative responses that ensue. Another theme, closely integrates with the first, is ....When nerve cells are damaged, destroyed or injured, through disease or trauma, common pathological processes are set in train. Even though there are many factors that might trigger disease, these inevitably lead to common processes that end in cell death or initiate protective processes. One theme involves the factors that surround these responses to nerve injury and stress, and the consequent protective and regenerative responses that ensue. Another theme, closely integrates with the first, is to exploit basic biological mechanisms with the aim of identifying and developing therapeutic targets for the management of a wider range of neurological conditions.Read moreRead less