Modulation Of Telomere Length And Subtelomeric DNA Methylation In Response To Oxidative Stress In The Male Germ Line; Implications For Tumorigenesis In The Offspring
Funder
National Health and Medical Research Council
Funding Amount
$310,684.00
Summary
This research project is designed to elucidate how the quality of a father’s spermatozoa can impact upon the health and wellbeing of his children. We hypothesize that factors, such as infertility, heavy smoking or age create a state of oxidative stress in the testes and that this stress influences the genetic structure of spermatozoa in such a way that the incidence of spontaneous mutations and susceptibility-to-cancer are significantly elevated in the offspring.