Reduction Of Oxygen After Cardiac Arrest: The EXACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,891,021.00
Summary
We aim to conduct a Phase 3 multi-centre, randomised, controlled trial to determine whether reducing oxygen administration to target a normal level as soon as possible following successful resuscitation from out-of-hospital cardiac arrest, compared to current practice of maintaining 100% oxygen, improves patient survival at hospital discharge.
Only at the movies: mapping the contemporary Australian cinema market. Only at the movies? is a three-year project that asks: What is the enduring appeal of cinemagoing and how is it changing? It will provide detailed analyses of formal film exhibition and distribution in Australia by combining economic, cultural and geospatial research with industry expertise.
Oxygen To Relieve Dyspnoea In Non-hypoxaemic Patients With End-stage Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$445,658.00
Summary
Chronic heart failure is a cause of suffering and a major cause of death in the Australian community. Patients who have chronic heart failure suffer from a range of symptoms that severely impacts every aspect of their life. One of the most common and distressing symptoms is breathlessness. As people with heart failure near death, their breathlessness may worsen not only in terms of its frequency, but also in its intensity. This worsening of symptoms is a source of great distress, both to patient ....Chronic heart failure is a cause of suffering and a major cause of death in the Australian community. Patients who have chronic heart failure suffer from a range of symptoms that severely impacts every aspect of their life. One of the most common and distressing symptoms is breathlessness. As people with heart failure near death, their breathlessness may worsen not only in terms of its frequency, but also in its intensity. This worsening of symptoms is a source of great distress, both to patients as well as their carers and family. Breathlessness is also the most common cause of admission to hospital for patients. A key strategy for managing this distressing symptom in the home is the supply of oxygen. However, due to a lack of scientific evidence for the benefit of home oxygen for people with heart failure, who do not necessarily have low levels of oxygen, it is very difficult for clinicians to access this therapy for their patients. This study seeks to assess if a specific breathlessness action plan alone or if the addition of either oxygen or air can relieve this distressing symptom. The scientific evaluation of these strategies will assist in improving the palliative care of people with chronic heart failure.Read moreRead less
The skin of commerce: the role of plastic packaging in the construction of food security, waste and consumer activism in Australia. Plastic packaging has been important to ensuring food security in Australia, however it is also a major waste burden. This project will critically assess new approaches to reducing plastic packaging in food markets and waste streams and will produce key insights into how sustainable food systems can be organised with less reliance on plastic.
Do The Mitochondrial Sirtuin Enzymes, SIRT3 And SIRT5, Affect Insulin Action In Skeletal Muscle?
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and ty ....Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and type 2 diabetes.Read moreRead less
From the Tap to the Bottle: an international study of the social and material life of bottled water. Water is a critical resource in Australia yet little is known about water in bottles. This project will be the first comparative study of bottled water marketing, consumption and disposal. It will make a significant contribution to national and international understandings of changing practices in the consumption of drinking water. The research will produce an analysis of the rise of the bottle i ....From the Tap to the Bottle: an international study of the social and material life of bottled water. Water is a critical resource in Australia yet little is known about water in bottles. This project will be the first comparative study of bottled water marketing, consumption and disposal. It will make a significant contribution to national and international understandings of changing practices in the consumption of drinking water. The research will produce an analysis of the rise of the bottle in relation to the tap. Specifically, how various anxieties associated with drinking tap water, in Australia and elsewhere, impact on bottled water consumption. The knowledge produced about bottled water collection, circulation and regulation will contribute to wider debates about sustainable water provision and access to safe water for all.Read moreRead less
Exploring Internet Induced Changes in Youth Music Consumption. Music consumption is the basis of both a key Australian industry with wide reaching economic impact, and a social practice closely tied to identity formation, relationship development and mood management. This project has significant community and national benefit, in that it will further our understanding of contemporary popular music consumption. In documenting the range of online music products, young consumers' attitudes towards ....Exploring Internet Induced Changes in Youth Music Consumption. Music consumption is the basis of both a key Australian industry with wide reaching economic impact, and a social practice closely tied to identity formation, relationship development and mood management. This project has significant community and national benefit, in that it will further our understanding of contemporary popular music consumption. In documenting the range of online music products, young consumers' attitudes towards them, and their personal music acquisition habits, the project will lead to an understanding of how having access to almost unlimited, personalised music-file collections will affect the role music plays in their lives and the follow-on impact in social, cultural and economic terms.Read moreRead less
The Wealth Effect: A cultural analysis of prosperity, financialisation and everyday life in contemporary Australia. Financial and real estate markets are now central to Australian family life. But current government policies to individualise responsibility for saving and borrowing decisions often exceed the individual capacity to manage complex financial choices and unknown market risks. Growing levels of home and property ownership bring new benefits but they also increase exposure to economic ....The Wealth Effect: A cultural analysis of prosperity, financialisation and everyday life in contemporary Australia. Financial and real estate markets are now central to Australian family life. But current government policies to individualise responsibility for saving and borrowing decisions often exceed the individual capacity to manage complex financial choices and unknown market risks. Growing levels of home and property ownership bring new benefits but they also increase exposure to economic downturn. For many households the Great Australian Dream of home ownership and prosperity has now turned into a nightmare. This project responds to the pressing need for greater understanding of these developments, and will advance our understanding of this new socio-economic terrain.Read moreRead less
Reducing The Effects Of Antenatal Alcohol On Child Health (REAACH)
Funder
National Health and Medical Research Council
Funding Amount
$2,497,397.00
Summary
Use of alcohol in pregnancy can affect the developing baby and cause Fetal Alcohol Spectrum Disorders (FASD). Children with FASD have lifelong brain injury that can lead to poor school performance, poor mental health and trouble with the law. This CRE builds on our strong background in research and community engagement to improve FASD prevention, diagnosis and treatment across Australia.
Parental Supply Of Alcohol To Children: Associations With Early Adult Health – “binge” Drinking, Alcohol-related Harms, Aggression, And Alcohol Use Disorders
Funder
National Health and Medical Research Council
Funding Amount
$1,143,477.00
Summary
We will investigate of the impacts of parental supply of alcohol between 13-18 years, on early adult alcohol use (19-23 years). We will follow an existing cohort of ~1,810 parent-child dyads, and assess the development of alcohol use, disorders, harms and aggression. We will investigate the impacts of: parental supply of sips vs drinks; supervised vs unsupervised supply; and modifying effects of contexts of supply and mediators (such as peer, child factors, etc.) controlling for confounders.