Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries s ....How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries species to evaluate their climate resilience. An advanced food web model will be developed to forecast changes to fisheries production in a future world. This provides a much-improved forecast of climate adaptation and managing future biodiversity and fisheries species through resilient genes and populations.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Does larval environment dictate resilience in a changing ocean? . This project aims to investigate the impact of global environmental change on the survival of key marine and freshwater invertebrates. This project expects to generate new knowledge using an interdisciplinary approach to understand the roles of diet and environment in invertebrate stress tolerance. Expected outcomes from this project include crucial insights into biological responses and extinction risk in a changing ocean. This s ....Does larval environment dictate resilience in a changing ocean? . This project aims to investigate the impact of global environmental change on the survival of key marine and freshwater invertebrates. This project expects to generate new knowledge using an interdisciplinary approach to understand the roles of diet and environment in invertebrate stress tolerance. Expected outcomes from this project include crucial insights into biological responses and extinction risk in a changing ocean. This should provide significant benefits, such as enhanced capacity to safeguard natural populations and habitats crucial to Australian industries and integral to maintaining the links of Indigenous Australians with their lands.Read moreRead less
The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyst ....The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyster populations and the Australian oyster industry, to enable the restoration of degraded oyster habitats. This project will ensure the future of an iconic and economically important national industry and food source and contribute to preserving the critical cultural links of Indigenous Australians with their lands.Read moreRead less
Optimising community-based climate change adaptation in the Pacific Islands. Optimising community-based climate change adaptation in the Pacific Islands. This project aims to evaluate community level climate change interventions in the Pacific to provide guidelines for better practice. The effects of climate change—rising sea levels, more droughts, and more frequent and intense storm activity—have been particularly concentrated in tropical areas such as the Pacific Islands. In response, interven ....Optimising community-based climate change adaptation in the Pacific Islands. Optimising community-based climate change adaptation in the Pacific Islands. This project aims to evaluate community level climate change interventions in the Pacific to provide guidelines for better practice. The effects of climate change—rising sea levels, more droughts, and more frequent and intense storm activity—have been particularly concentrated in tropical areas such as the Pacific Islands. In response, interventions to adapt to a diversity of impacts have accelerated at the community level across the region, but there has been no analysis of their long-term effectiveness in reducing livelihood and resource vulnerability to climate change.Read moreRead less
About time: Climate change adaptation in Australian industries. This project aims to assist the most vulnerable industries in Australia as they adapt to climate change. By investigating the interplay between industry practices and climate impacts, the project proposes to develop a theoretical conceptualization of time. This is significant in addressing the temporal tension between financial short-termism and future climate commitments. The expected outcomes include advancing the scholarly discus ....About time: Climate change adaptation in Australian industries. This project aims to assist the most vulnerable industries in Australia as they adapt to climate change. By investigating the interplay between industry practices and climate impacts, the project proposes to develop a theoretical conceptualization of time. This is significant in addressing the temporal tension between financial short-termism and future climate commitments. The expected outcomes include advancing the scholarly discussion of time and the creation of a practical tool in the form of digital stories that will make sustainable futures actionable. This benefits Australian industries by strengthening their capacity to meet the future challenges of climate change.Read moreRead less
Assessing the adaptive capacity of hospital facilities to cope with climate-related extreme weather events: A risk management approach. Given Australia's and New Zealand's relatively high exposure to climate extremes, the social, economic and health benefits of better managed hospital facilities are significant. Floods, bushfires, heatwaves and cyclones cost Australia over $1.4bn/year and New Zealand over NZ$43m/yr in disruption to communities, business productivity and damage to infrastructure. ....Assessing the adaptive capacity of hospital facilities to cope with climate-related extreme weather events: A risk management approach. Given Australia's and New Zealand's relatively high exposure to climate extremes, the social, economic and health benefits of better managed hospital facilities are significant. Floods, bushfires, heatwaves and cyclones cost Australia over $1.4bn/year and New Zealand over NZ$43m/yr in disruption to communities, business productivity and damage to infrastructure. This research will help to mitigate these costs by protecting populations from the health risks associated with such events. The potential benefits will be most significant for those vulnerable communities at high risk such as the aged, the obese, the ill and those geographically exposed to more extreme weather events.Read moreRead less
Does physiological plasticity of individuals render populations resilient to climate change? Abrupt environmental changes can put natural populations at risk of extinction. The project will show to what extent individuals can compensate for temperature changes and thereby render populations resilient to climate change. This research will make theoretical advances and improve the power to predict impacts of future climate change.
Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of mul ....Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of multi-disciplinary approaches, ranging from future climate models, historical satellite data to in-field experimentation to fill fundamental knowledge gaps in our understanding of coral bleaching recovery and delivery a variety of management and stakeholder relevant outputs.Read moreRead less