Improving Pain And Movement Outcomes In Symptomatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
People fear getting painful knee osteoarthritis (OA) more than any other disease – it is seen as progressive and incurable. It often stops people from moving and staying healthy, resulting in an enormous burden on sufferers and the health care system. This program of research aims to understand what brain & nervous system processes might underlie these pain and movement problems and whether new brain-targeting treatment helps. This will allow us to better match treatment to what patients need.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
The role of epigenetic modifications in bovid adaptation to environmental change. This project will explore the role of epigenetic change, where gene expression is regulated without changing the deoxyribonucleic acid (DNA) sequence, in how animals adapt to rapid climate change. This project will trace epigenetic markers in ancient bison and cows through 30,000 years of climate change, and identify key adaptive genes for the cattle industry.
ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ....ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ecoinformatics and evolutionary theory. Across this span, working groups will target nine identified opportunities for breakthrough research. Each research target needs input from two or more disciplines. Together, the nine targets link across disciplines, as a network that spans from genomic to planetary scales.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100022
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
New frontier in Geoscience: A tandem trace element and isotopes facility. The project aims to integrate a multicollector mass spectrometer with the existing laser ablation laboratory at Southern Cross University to establish a unique facility offering tandem trace element and isotopes analysis. This will provide new methodological advancement by expanding the analytical range and obtaining information otherwise inaccessible to stand-alone instruments using traditional standardisation methods. Sp ....New frontier in Geoscience: A tandem trace element and isotopes facility. The project aims to integrate a multicollector mass spectrometer with the existing laser ablation laboratory at Southern Cross University to establish a unique facility offering tandem trace element and isotopes analysis. This will provide new methodological advancement by expanding the analytical range and obtaining information otherwise inaccessible to stand-alone instruments using traditional standardisation methods. Specifically, the integration of an innovative split stream system allows precise matching of elemental concentration with isotopic ratios, crucial for microscale resolution and data accuracy. The new infrastructure will confirm Australia’s leadership role and maintain its competitive advantage in geosciences.Read moreRead less
Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced sp ....Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced species and increased human use of coastal resources affect dynamic plankton ecosystems. This project’s findings are expected to explore cyclical patterns, define range expansions and understand and manage how dynamic coastal ecosystems respond to multistressor anthropogenic change. Findings will improve understanding of how dynamic marine environments retain their biodiversity values and critical ecological functions.Read moreRead less
Regime change: when and how do ecological subordinates turn dominant? This project aims to bridge the gap between physiology and ecology in kelp forest species by developing mechanistic models to predict change and, in an unprecedented step, test them in long-term experiments at naturally acidified sites to understand the consequences of ocean acidification (OA) and warming for kelp forests. Ecosystem change is a frequent outcome of decadal modifications of the physical and chemical environment. ....Regime change: when and how do ecological subordinates turn dominant? This project aims to bridge the gap between physiology and ecology in kelp forest species by developing mechanistic models to predict change and, in an unprecedented step, test them in long-term experiments at naturally acidified sites to understand the consequences of ocean acidification (OA) and warming for kelp forests. Ecosystem change is a frequent outcome of decadal modifications of the physical and chemical environment. Whilst these changes often involve degradation from productive states, we have a poor understanding of the mechanisms which drive change. Key stressors in marine systems, OA and warming are predicted to drive loss of kelp forests but we still don't understand the reality of these predictions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560751
Funder
Australian Research Council
Funding Amount
$432,474.00
Summary
Facility for the Analysis of Biomacromolecular Interactions. A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available ....Facility for the Analysis of Biomacromolecular Interactions. A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available only in small quantities, and small, drug related molecules (by microcalorimetry and dual polarization interferometry), and (ii) provide equipment necessary for sample characterization and purification prior to quantitative measurements (CD spectroscopy, and FPLC equipment).Read moreRead less
Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidenc ....Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidence of these keystones’ cellular level biogeochemical and metabolic capacity. Ultimately, this knowledge is expected to predict the resilience of ocean ecosystems and their response to change. The capacity to predict their dynamics will help provide investment clarity and increase healthy outcomes from activities involving human-ocean interactions such as recreation, food production and tourism.Read moreRead less
Species and gene turnover across environmental gradients - a landscape-level approach to quantify biodiversity and resilience for climate adaptation. Biodiversity corridor planning in Australia desperately needs to progress beyond the simple linking up of remnant vegetation, based on aerial maps and start incorporating ecosystem features which will promote climate adaptation. This project will develop a new genomics method to assess ecosystem resilience for use in national biodiversity corridor ....Species and gene turnover across environmental gradients - a landscape-level approach to quantify biodiversity and resilience for climate adaptation. Biodiversity corridor planning in Australia desperately needs to progress beyond the simple linking up of remnant vegetation, based on aerial maps and start incorporating ecosystem features which will promote climate adaptation. This project will develop a new genomics method to assess ecosystem resilience for use in national biodiversity corridor planning.Read moreRead less