Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Optimising community-based climate change adaptation in the Pacific Islands. Optimising community-based climate change adaptation in the Pacific Islands. This project aims to evaluate community level climate change interventions in the Pacific to provide guidelines for better practice. The effects of climate change—rising sea levels, more droughts, and more frequent and intense storm activity—have been particularly concentrated in tropical areas such as the Pacific Islands. In response, interven ....Optimising community-based climate change adaptation in the Pacific Islands. Optimising community-based climate change adaptation in the Pacific Islands. This project aims to evaluate community level climate change interventions in the Pacific to provide guidelines for better practice. The effects of climate change—rising sea levels, more droughts, and more frequent and intense storm activity—have been particularly concentrated in tropical areas such as the Pacific Islands. In response, interventions to adapt to a diversity of impacts have accelerated at the community level across the region, but there has been no analysis of their long-term effectiveness in reducing livelihood and resource vulnerability to climate change.Read moreRead less
Assessing the adaptive capacity of hospital facilities to cope with climate-related extreme weather events: A risk management approach. Given Australia's and New Zealand's relatively high exposure to climate extremes, the social, economic and health benefits of better managed hospital facilities are significant. Floods, bushfires, heatwaves and cyclones cost Australia over $1.4bn/year and New Zealand over NZ$43m/yr in disruption to communities, business productivity and damage to infrastructure. ....Assessing the adaptive capacity of hospital facilities to cope with climate-related extreme weather events: A risk management approach. Given Australia's and New Zealand's relatively high exposure to climate extremes, the social, economic and health benefits of better managed hospital facilities are significant. Floods, bushfires, heatwaves and cyclones cost Australia over $1.4bn/year and New Zealand over NZ$43m/yr in disruption to communities, business productivity and damage to infrastructure. This research will help to mitigate these costs by protecting populations from the health risks associated with such events. The potential benefits will be most significant for those vulnerable communities at high risk such as the aged, the obese, the ill and those geographically exposed to more extreme weather events.Read moreRead less
Does physiological plasticity of individuals render populations resilient to climate change? Abrupt environmental changes can put natural populations at risk of extinction. The project will show to what extent individuals can compensate for temperature changes and thereby render populations resilient to climate change. This research will make theoretical advances and improve the power to predict impacts of future climate change.
ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ....ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ecoinformatics and evolutionary theory. Across this span, working groups will target nine identified opportunities for breakthrough research. Each research target needs input from two or more disciplines. Together, the nine targets link across disciplines, as a network that spans from genomic to planetary scales.Read moreRead less
450 Million year history of plant gas exchange capacity and the role of atmospheric carbon dioxide. Our planet faces an increase in atmospheric carbon dioxide that is unprecedented in human history, but has occurred in ancient times. By studying the relationship between past changes in atmospheric carbon dioxide, plant gas exchange and climate we will gain powerful global insight into future scenarios of continental carbon and water fluxes. This global perspective is essential for Australia to a ....450 Million year history of plant gas exchange capacity and the role of atmospheric carbon dioxide. Our planet faces an increase in atmospheric carbon dioxide that is unprecedented in human history, but has occurred in ancient times. By studying the relationship between past changes in atmospheric carbon dioxide, plant gas exchange and climate we will gain powerful global insight into future scenarios of continental carbon and water fluxes. This global perspective is essential for Australia to assess its vulnerability to global climate change in relation to other nations, thereby informing national planning of landscape resource use, including primary industry, water infrastructure and carbon trading.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668477
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Upgrade of existing university low field and high field nuclear magnetic resonance facilities. The ongoing pursuit of new medicines and therapies, the development of sustainable forestry management practices and the assessment of the impact of global climate change on Australian forest soils are some of the research objectives being addressed by researchers at Griffith University. The Eskitis Institute for Cell and Molecular Therapies and the Centre for Forestry and Horticultural Research (CFHR) ....Upgrade of existing university low field and high field nuclear magnetic resonance facilities. The ongoing pursuit of new medicines and therapies, the development of sustainable forestry management practices and the assessment of the impact of global climate change on Australian forest soils are some of the research objectives being addressed by researchers at Griffith University. The Eskitis Institute for Cell and Molecular Therapies and the Centre for Forestry and Horticultural Research (CFHR) bring together researchers from a range of disciplines to further research in these key areas. The instruments funded here will provide researchers with access to spectroscopic facilities with state-of-the-art performance. This will ensure the continued international competitiveness and the sustained productivity of our research programmes.Read moreRead less
How does the interaction between environmental drivers determine the impact of global change on animals? There is an urgent need to determine how vulnerable natural populations are to simultaneous changes in more than one environmental driver. This project will take an integrative approach, using molecular, physiological and ecological tools, to determine whether cellular responses to the interaction between UV-B radiation and temperature vary between populations, and within individuals over tim ....How does the interaction between environmental drivers determine the impact of global change on animals? There is an urgent need to determine how vulnerable natural populations are to simultaneous changes in more than one environmental driver. This project will take an integrative approach, using molecular, physiological and ecological tools, to determine whether cellular responses to the interaction between UV-B radiation and temperature vary between populations, and within individuals over time. This project will bridge the gap between physiology and ecology by testing whether molecular responses translate into fitness benefits for the organism to gain an understanding at a level that is relevant for conservation. Read moreRead less
Water resource management of the Snowy Mountains Hydro-electric Scheme catchment and the Murray-Darling River system - a new perspective on system reliability from drought history reconstruction. The Snowy Mountains Hydro-electric Scheme assists in underwriting the production of $3 billion of agricultural products in the Murray-Darling Basin each year by providing a reliable source of water west of the Great Dividing Range, while Hydro-electric generation from the Scheme is worth annually severa ....Water resource management of the Snowy Mountains Hydro-electric Scheme catchment and the Murray-Darling River system - a new perspective on system reliability from drought history reconstruction. The Snowy Mountains Hydro-electric Scheme assists in underwriting the production of $3 billion of agricultural products in the Murray-Darling Basin each year by providing a reliable source of water west of the Great Dividing Range, while Hydro-electric generation from the Scheme is worth annually several hundred million dollars and provides 70% of the renewable energy supplied to the eastern mainland grid, thereby avoiding 5Mt of carbon dioxide emissions each year. This study will ensure the ongoing sustainable and efficient management of the Schemes water resources in response to predicted climate variability and most importantly, severe drought. Read moreRead less