Whiplash Injury: Mechanisms, Prediction And Directives For Improved Management Strategies.
Funder
National Health and Medical Research Council
Funding Amount
$772,359.00
Summary
Whiplash is a costly condition with many people developing chronic symptoms. This research aims to improve the understating of involved mechanisms, diagnosis and classification of the condition from the time of injury until either recovery or the development of persistent pain. This will facilitate the early identification of those at risk of poor recovery and will lay the foundations for the development of improved early management, particularly in primary care.
Chronic pain afflicts 1 in 5 Australians; it is one of our most expensive health care problems. Prof Moseley's research asks: (1) Why do some people get chronic pain but others don't? (ii) How can we treat chronic pain so sufferers can return to a meaningful, productive and comfortable life? (iii) How can we stop chronic pain from developing in the first place? His research involves behavioural and physiological experiments in humans, that lead to new treatments, which are tested in clinical tri ....Chronic pain afflicts 1 in 5 Australians; it is one of our most expensive health care problems. Prof Moseley's research asks: (1) Why do some people get chronic pain but others don't? (ii) How can we treat chronic pain so sufferers can return to a meaningful, productive and comfortable life? (iii) How can we stop chronic pain from developing in the first place? His research involves behavioural and physiological experiments in humans, that lead to new treatments, which are tested in clinical trials.Read moreRead less
Physiology And Pathophysiology Of Disorders Of The Musculoskelatal System
Funder
National Health and Medical Research Council
Funding Amount
$898,008.00
Summary
I am a neuroscientist and physiotherapist focussed on the conservative management of disorders of the musculoskeletal system. My research aims to uncover the mechanisms underlying musculoskeletal pain and other disorders such as incontinence, to develop and refine treatments for these conditions, and to understand the mechanism for efficacy of these treatments.
In a human body, about a million cells are born every second, and a million die by activating a physiological cell death mechanism. If cell death fails to occur, cells accumulate and can develop into cancers. Determining the mechanism and regulation of physiological cell death will provide novel approaches to treat cancers and auto-immune diseases, both of which are characterised by failure of certain cells to die.
Improving Outcomes For Older People With Musculoskeletal Foot Disorders
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
Foot pain affects one in four older Australians and leads to difficulty walking, loss of independence and reduced quality of life. The research outlined in this application will address this common but largely ignored health problem by improving our knowledge of the causes of foot pain, developing novel treatments for foot disorders incorporating specialised exercises, footwear and insoles, and testing the effectiveness of these interventions in clinical trials.
I am a physiologist-pharmacologist examining fundamental mechanisms of chronic inflammatory disease. By defining these mechanisms, I seek to discover the underlying cause of disease and to identify novel strategies for diagnosis and therapy of chronic diseases that are worldwide causes of morbidity and mortality.
Regulation And Mechanisms Of Cell Cycling, Cell Senescence And Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
Most of our cells are not dividing, but persist in a stable arrested state, yet little is known of the molecular mechanisms that regulate and maintain permanent arrest, or that go wrong when cells start proliferating and turn into cancers. This proposal addresses an area of fundamental, basic biology, that has been largely overlooked. A better understanding of the molecules that regulate cell stability might provide new drug targets so that tumour cell proliferation can be stopped.
Innovation In The Primary Care Management Of Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$152,595.00
Summary
Back pain affect millions of Australians. Billions of dollars are spent each year on treament but health outcomes are often poor. Experience from overseas shows that simply spending more money on current treatments won’t fix the problem. This fellowship will be used to support a program of research to improve the quality and efficiency of treatments and health services.
Venoms To Drugs: Translating Venom Peptides Into Human Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
Many disorders of the nervous system, including chronic pain, epilepsy and the neuronal degeneration suffered following a stroke, result from malfunction of channels that ferry ions across neuronal cell membranes. There are very few drugs available for treating these disorders and they often have debilitating side-effects. We are developing potent and selective modulators of these ion channels as the next-generation of safe and effective analgesic, anti-epileptic, and neuroprotective drugs.
Discovery And Development Of Novel Venom Peptide Analgesics
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Professor Lewis will discover and develop new research tools and potential therapeutics from toxins acting on pain pathways. The Fellowship will leverage (i) well-funded collaborations with top Australian and international scientists (ii) the recently established IMB Centre for Pain Research that I lead as inaugural Director, and (iii) an outstanding Institute equipped with leading edge technologies for high throughput and high content discovery and proteomic and transcriptomic analysis.