Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimod ....Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimodal dataset generated by the project will be made publicly available to enhance research transparency and international collaboration. This should provide significant benefits, ultimately opening up ways to improve quality of life and wellbeing of the Australian population.
Read moreRead less
The neural dynamics of real-time processing in the brain. The aim of this project is to investigate a new model for predictive coding of sensory processing in the brain in which the brain compensates for the time delays in neural transmission by maintaining a real-time temporal alignment of the neural activity. This results in a representation of sensory information that is aligned in time across the cortex, offering a new fundamental principle for how the brain functions in a highly dynamic wor ....The neural dynamics of real-time processing in the brain. The aim of this project is to investigate a new model for predictive coding of sensory processing in the brain in which the brain compensates for the time delays in neural transmission by maintaining a real-time temporal alignment of the neural activity. This results in a representation of sensory information that is aligned in time across the cortex, offering a new fundamental principle for how the brain functions in a highly dynamic world whose outcomes would provide a deeper understanding of brain function. It could also have profound significance for artificial intelligence and brain-inspired technologies, as well as benefit neural sensory prostheses and brain-machine interfaces.Read moreRead less
Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge ....Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge of which spatial visual mechanisms are altered due to age, supplying key information for understanding and improving visual environments for the elderly, as well as increasing knowledge of the brain mechanisms susceptible to the ageing process.Read moreRead less
The Claustrum Enigma: Unlocking The Role Of The Last Unknown Area Of The Primate Brain
Funder
National Health and Medical Research Council
Funding Amount
$558,364.00
Summary
Despite nearly 200 years of study, the function of the claustrum remains unclear. Interest in this brain structure has recently been revived by findings showing damage to the claustrum in several major diseases, and by the suggestion that the claustrum may have a role in consciousness. Here we propose a series of experiments to test the novel hypothesis that the claustrum is part of the default mode network, a group of brain areas that act together when we aren't thinking about anything in parti ....Despite nearly 200 years of study, the function of the claustrum remains unclear. Interest in this brain structure has recently been revived by findings showing damage to the claustrum in several major diseases, and by the suggestion that the claustrum may have a role in consciousness. Here we propose a series of experiments to test the novel hypothesis that the claustrum is part of the default mode network, a group of brain areas that act together when we aren't thinking about anything in particular, that is- most of the time.Read moreRead less
Chromatic Inputs to Cortical Receptive Fields in Primates. The human eye contains three kinds of receptors for daytime vision, named blue, green and red cones for their sensitivity to different regions of the visible spectrum. It is known that blue cones contribute to brain pathways for colour vision, but recent data suggest there is also 'cross-talk' of blue cone signals to pathways for motion and high-acuity vision. This project comprises precise measurement of blue cone signals, and anatomica ....Chromatic Inputs to Cortical Receptive Fields in Primates. The human eye contains three kinds of receptors for daytime vision, named blue, green and red cones for their sensitivity to different regions of the visible spectrum. It is known that blue cones contribute to brain pathways for colour vision, but recent data suggest there is also 'cross-talk' of blue cone signals to pathways for motion and high-acuity vision. This project comprises precise measurement of blue cone signals, and anatomical tracing of blue cone pathways, in a primate model for human vision. The data will improve our basic knowledge of how the brain processes sensory signals.Read moreRead less
Discovering justified knowledge from data. Knowledge discovery from data has assumed a critical role in numerous areas of science, commerce and public administration. However, its effectiveness is limited by the undesirable propensity of current techniques to make many false, as well as real, discoveries. This research will rectify that problem, a critical outcome given the potential cost of making decisions or setting policy using flawed information. For example, it may prevent the adoption of ....Discovering justified knowledge from data. Knowledge discovery from data has assumed a critical role in numerous areas of science, commerce and public administration. However, its effectiveness is limited by the undesirable propensity of current techniques to make many false, as well as real, discoveries. This research will rectify that problem, a critical outcome given the potential cost of making decisions or setting policy using flawed information. For example, it may prevent the adoption of ineffective strategies for addressing land degradation; inappropriately targeted public health expenditure; expensive development and clinical trialing of drugs which prove ineffective; and wasted police and security investigations into unfounded suspicions of criminal or terrorist activity.Read moreRead less
Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
The brain in real-time: predicting the present, reconstructing the past. This proposal aims to understand how the brain compensates for its own internal delays to function in real-time. Because it takes time for information from the senses to reach the brain, it takes time for us to become aware of an event that occurs in the outside world. This project will use an innovative combination of techniques to study how prediction and reconstruction mechanisms work together in the brain. Expected outc ....The brain in real-time: predicting the present, reconstructing the past. This proposal aims to understand how the brain compensates for its own internal delays to function in real-time. Because it takes time for information from the senses to reach the brain, it takes time for us to become aware of an event that occurs in the outside world. This project will use an innovative combination of techniques to study how prediction and reconstruction mechanisms work together in the brain. Expected outcomes of this project include a fundamental understanding of how we function in the present. This should provide significant benefits, such as an important theoretical advance in our understanding of how conscious awareness is realised in the brain, placing Australia at the cutting edge.Read moreRead less