Localising Epileptic Discharges In The Brain Using Non-invasive Electro-magnetic Signal Analysis In Patients With Difficult-to-control Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$179,782.00
Summary
Epilepsy is a leading cause of chronic morbidity in Australia. A fundamental problem in clinical practice is the accurate identification of the 'hotspot' zone in the brain that is generating epileptic discharges. These discharges can be detected non-invasively (over the scalp) and analysed with electro-encephalographic and magneto-encephalographic source localisation (EMSL) techniques. EMSL is not used in routine clinical practice because we await a large scale prospective study (the aim of this ....Epilepsy is a leading cause of chronic morbidity in Australia. A fundamental problem in clinical practice is the accurate identification of the 'hotspot' zone in the brain that is generating epileptic discharges. These discharges can be detected non-invasively (over the scalp) and analysed with electro-encephalographic and magneto-encephalographic source localisation (EMSL) techniques. EMSL is not used in routine clinical practice because we await a large scale prospective study (the aim of this proposal).Read moreRead less
Spatial Coding In The Primate Cortex During Eye Movements.
Funder
National Health and Medical Research Council
Funding Amount
$428,720.00
Summary
Every time we move our eyes, objects in the world change their positions on the retina, yet to us, their positions remain perceptually unchanged. This project seeks to understand how neurons in the primate brain combine visual input with signals about eye position to construct this stable representation of external space. The findings will help us understand and-or rehabilitate a host of nervous system dysfunctions, including schizophrenia, stroke, and paraplegia.
Investigation Of 5-methylcytosine And MicroRNA Function In Eukaryotic RNA
Funder
National Health and Medical Research Council
Funding Amount
$311,991.00
Summary
It is hypothesised that 5-methylcytosine in RNA represents a novel regulatory code affecting transcriptome utilisation in ways currently hidden from view. To unravel this code and its (patho)- physiological role(s), this study proposes to generate and interpret comprehensive transcriptome-scale maps of 5-methylcytosine in a range of cellular contexts chosen to reveal links to cellular differentiation, growth, and malignant transformation.
I-Medic (Intelligent Monitoring And Early Diagnosis In Communities)
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
Falls cost $500 million annually and are increasing as our population ages. Dr Brodie has developed i-Medic, Intelligent Monitoring and Early Diagnosis In Communities. He is answering the questions: Why do people fall? How can we predict falls? And how do we prevent falls? His software, which may be incorporated into all future mobile phones, is capable of detecting, predicting and therefore preventing falls. In the event of a fall the software also activates an emergency response.
Opening Windows To The Listening Brain: Developing Objective Measures Of Hearing Acuity In The Human Brain.
Funder
National Health and Medical Research Council
Funding Amount
$319,329.00
Summary
Up to 160,000 Australians are un-employed due to hearing impairment, costing an estimated $12 billion per year. I will undertake systematic research which will result in EEG-based clinical tools designed to measure the reliability and acuity with which brainstem and brain structures are able to encode fine details in sounds. These tools will improve diagnostic and prognostic tests, especially for clinicians and parents of infants diagnosed with auditory neuropathies.
Investigation Of Small Molecule Interactions With The Human Leukocyte Antigen And Their Role In Non-infectious Disease
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The Human Leukocyte Antigens (HLA) play a key role in the immune system helping the body differentiate healthy from diseased cells. Numerous autoimmune diseases and adverse drug reactions are associated with specific HLA variants. This study seeks to unlock the mechanisms behind these diseases, investigating how small molecules including drugs interact with the HLA to make healthy body cells seem foreign. This research has the potential to inform strategies for disease avoidance and management.