Linking evolutionary and molecular biology to safeguard Australian honeybees. Honeybee populations are declining globally but their pollination services are of central importance for food production. This project will study honeybee proteins that influence both fertility and immunity and their effects in vivo. This knowledge is of interest for the bee breeding industry to avoid or combat bee declines in managed Australian bees.
Does coevolution drive speciation? This project aims to connect micro-evolutionary processes with macro-evolutionary patterns to test the extent to which tightly coupled co-evolutionary interactions between species drive evolutionary diversification. The project will use techniques including the most recent phylogenetic modelling methods, field experiments and molecular genetics. Expected outcomes include advancing understanding of the mechanisms that generate biodiversity and developing new tec ....Does coevolution drive speciation? This project aims to connect micro-evolutionary processes with macro-evolutionary patterns to test the extent to which tightly coupled co-evolutionary interactions between species drive evolutionary diversification. The project will use techniques including the most recent phylogenetic modelling methods, field experiments and molecular genetics. Expected outcomes include advancing understanding of the mechanisms that generate biodiversity and developing new techniques for acquisition of DNA from museum specimens. The project is expected to provide significant benefits, such as insights into the processes that promote new species in nature.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101470
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Using social network models to understand the factors driving parasite transmission in bettong populations. Parasitic diseases pose a significant threat to Australia's biodiversity. This project will apply the use of social networks models to understanding how different parasites are spread through endangered bettong populations.
Safeguarding honeybees: understanding host-parasite interactions at the level of proteins. Parasites are responsible for dramatic declines of honeybee populations resulting in a loss of pollination services and posing a threat to food production and ecosystem stability. This project will study the honeybee immune system and its interactions with bee parasites on the molecular scale, which will be important to guide future bee breeding.
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee vi ....Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee viability. Furthermore, state-of-the-art nanotechnology will be used to develop benign treatments with enhanced effectiveness and minimal dosage/exposure to the bees. Outcomes of this project can have major impact on future parasite management in commercial honeybees.Read moreRead less
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
The ecology of parasite transmission in fauna translocations. Parasitic diseases pose a threat to the conservation management of Australia's biodiversity. This project will improve our understanding of the impact and transmission of parasites in fauna translocations, contributing to the conservation management of Australian ecosystems by government and private agencies.
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.