Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Mental Health Across Generations: Pre-and Post Conception Predicators Of Early Life Risks
Funder
National Health and Medical Research Council
Funding Amount
$666,231.00
Summary
In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death f ....In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death from a range of causes, including suicide. These conditions are significant in terms of prevalence and disease burden, and have far-reaching impacts for families, carers and others in the community. Mental health problems commonly cluster in families. However, few studies have previously been able to investigate the range of ways in which mental disorders may pass from one generation to another. Further, evidence suggests that influences that arise prior to conception may have major effects on early life risks such as development in utero, birth outcomes and early maternal infant bonding. Mental Health across Generations: Pre- and post-conception predictors of early life risks is a unique study that will examine antenatal maternal mental health and risk behaviours during pregnancy. The study will also examine the links between prior maternal mental health and later birth outcomes, and post natal maternal infant bonding. The risk processes to be tested will include genetic, epigenetic (changes in gene expression), physiological and psycho-social parameters.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668469
Funder
Australian Research Council
Funding Amount
$195,000.00
Summary
The Rapid Kinetics Research Facility - an Integrated system for rapid kinetic studies of materials using synchrotron radiation. The Rapid Kinetics Research Facility will provide Australian researchers with the tools to follow and understand very rapid processes within advanced materials. This will greatly assist in: i) the development of more efficient materials processing technologies, ii) the development of advanced catalysts able to neutralize pollutants and reduce the energy cost of industri ....The Rapid Kinetics Research Facility - an Integrated system for rapid kinetic studies of materials using synchrotron radiation. The Rapid Kinetics Research Facility will provide Australian researchers with the tools to follow and understand very rapid processes within advanced materials. This will greatly assist in: i) the development of more efficient materials processing technologies, ii) the development of advanced catalysts able to neutralize pollutants and reduce the energy cost of industrial processes, iii) the development of viable hydrogen fuel storage media and iv) the training of young Australian researchers in advanced methods of materials characterization. Read moreRead less
Left-handed metamaterials and negative refraction. This project will establish and support the first team in Australia working in the field of left-handed metamaterials, artificial materials in which waves behave in a unique and counter-intuitive way. The project will promote this new field, enhance its rapid development, and facilitate emerging novel technologies in Australia. It will also lead to close international collaborations with active theoretical and experimental groups, and bring impo ....Left-handed metamaterials and negative refraction. This project will establish and support the first team in Australia working in the field of left-handed metamaterials, artificial materials in which waves behave in a unique and counter-intuitive way. The project will promote this new field, enhance its rapid development, and facilitate emerging novel technologies in Australia. It will also lead to close international collaborations with active theoretical and experimental groups, and bring important expertise to Australia. We believe our initial efforts of purely fundamental nature and extensive collaboration with the overseas groups will have a significant impact on the development of this field and related novel technologies in Australia, attracting strong interest from industry.Read moreRead less
Electron Momentum Spectroscopy of Correlated Nanoscale Structures. Electron correlations play a vital role in determining the electronic properties of condensed matter and nanoscale structures. The most fundamental electronic property of a material is its spectral momentum density and this depends critically on electron correlations. It can be measured uniquely by electron momentum spectroscopy, even for amorphous and disordered materials. We will use our new world-leading electron momentum s ....Electron Momentum Spectroscopy of Correlated Nanoscale Structures. Electron correlations play a vital role in determining the electronic properties of condensed matter and nanoscale structures. The most fundamental electronic property of a material is its spectral momentum density and this depends critically on electron correlations. It can be measured uniquely by electron momentum spectroscopy, even for amorphous and disordered materials. We will use our new world-leading electron momentum spectrometer to measure the electronic structure of nanometer thick samples of correlated systems, such as alloys, superconductors, and reduced dimensional structures. These measurements will be used to test theories developed to describe the behaviour of these nanoscale structures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453842
Funder
Australian Research Council
Funding Amount
$590,309.00
Summary
National Facility for Electron Spin Correlations and Spintronics. Conventional electronics is based on coupling the charge of the electrons with external electric fields and light. Recent work on spintronics is directed toward the use of both the spin (angular momentum) and the charge degrees of freedom of the electron. We currently lead the world in the development of spin-resolved coincidence measurements, which make it possible to determine previously inaccessible nanoscale magnetic propertie ....National Facility for Electron Spin Correlations and Spintronics. Conventional electronics is based on coupling the charge of the electrons with external electric fields and light. Recent work on spintronics is directed toward the use of both the spin (angular momentum) and the charge degrees of freedom of the electron. We currently lead the world in the development of spin-resolved coincidence measurements, which make it possible to determine previously inaccessible nanoscale magnetic properties, central to 'spintronic structure engineering'. State-of-the-art instrumentation is requested to characterise the magnetic and crystallographic structure, the adsorbates, and the lateral distribution and depth profile of fabricated zero, one and two-dimensional structures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989123
Funder
Australian Research Council
Funding Amount
$575,000.00
Summary
Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside ....Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside the consortium. It will allow Australian researchers to remain at the leading edge of research and enhance collaborations in advanced materials nationwide. The successful outcomes of these activities will underpin the advancement in many areas of research and technology developments in the country.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100036
Funder
Australian Research Council
Funding Amount
$4,881,754.00
Summary
ARC Training Centre in Alloy Innovation for Mining Efficiency. ARC Training Centre in Alloy Innovation for Mining Efficiency. This centre aims to make Australian manufacturers dominant in the multi-billion dollar mining equipment sector by training innovators to design the world’s best highly customized long-life, wear resistant components. It intends to rapidly develop customized alloys that excel in severe mining conditions, using three-dimensional printing, novel characterisation and its netw ....ARC Training Centre in Alloy Innovation for Mining Efficiency. ARC Training Centre in Alloy Innovation for Mining Efficiency. This centre aims to make Australian manufacturers dominant in the multi-billion dollar mining equipment sector by training innovators to design the world’s best highly customized long-life, wear resistant components. It intends to rapidly develop customized alloys that excel in severe mining conditions, using three-dimensional printing, novel characterisation and its networked training environment. It expects these innovations will enable much needed efficiencies after the end of the mining super-cycle. Anticipated outcomes are the design of products with superior alloy design and material selection; jobs growth and security in the mining component production sector; and increased mining efficiency and cost reduction.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561186
Funder
Australian Research Council
Funding Amount
$447,967.00
Summary
Surface Mechanical Property Analysis Facility. The aim of this proposal is to develop a facility for the mechanical properties analysis of material surfaces. The facility will enable an understanding of the performance of materials in a wide range of contact and abrasion situations and in very small volumes such as thin films and components of multiphase composites. The unique features of the proposed facility are that it is capable of analysis down to exceptionally low sub-micron length scale, ....Surface Mechanical Property Analysis Facility. The aim of this proposal is to develop a facility for the mechanical properties analysis of material surfaces. The facility will enable an understanding of the performance of materials in a wide range of contact and abrasion situations and in very small volumes such as thin films and components of multiphase composites. The unique features of the proposed facility are that it is capable of analysis down to exceptionally low sub-micron length scale, under multiple forms of loading and over a range of temperatures. It is applicable to the design of abrasion resistant materials, characterisation of very thin surface films for applications such as microelectronics and biomedical implants and design of advanced composites.Read moreRead less
Many-Electron Dynamics and Electronic Structure of Materials Studied by Electron Momentum Spectroscopy. Electron momentum spectroscopy is a technique that resembles playing pool with electrons. This technique, largely developed in Australia, determines the binding energy and velocity distribution of electrons in matter. This distribution, closely related to the quantum mechanical wave function of the electrons, can be compared directly with calculations of the electronic structure. Such a compa ....Many-Electron Dynamics and Electronic Structure of Materials Studied by Electron Momentum Spectroscopy. Electron momentum spectroscopy is a technique that resembles playing pool with electrons. This technique, largely developed in Australia, determines the binding energy and velocity distribution of electrons in matter. This distribution, closely related to the quantum mechanical wave function of the electrons, can be compared directly with calculations of the electronic structure. Such a comparison helps establish which theory approaches nature most closely, and thus improves our understanding of the electronic structure. This understanding helps to predict the properties of materials, and hence this knowledge will facilitate the design of materials with desirable properties.Read moreRead less