Patellofemoral Joint Osteoarthritis: The Effect Of Foot Orthoses
Funder
National Health and Medical Research Council
Funding Amount
$99,002.00
Summary
Despite the burden of patellofemoral joint osteoarthritis (PFJ OA), there is a paucity of evidence for conservative treatments. This project aims to determine the functional features of PFJ OA and develop a clinical tool to enable identification of features associated with PFJ OA. A randomised controlled trial will then be conducted utilising a foot orthoses intervention to determine whether foot orthoses improve function and pain in people with PFJ OA.
Patellofemoral Arthritis: Efficacy Of Physiotherapy And Understanding The Role Of Joint Stress
Funder
National Health and Medical Research Council
Funding Amount
$616,430.00
Summary
Arthritis of the kneecap leads to considerable pain and difficulty with daily activities. This project is testing whether a physiotherapy treatment (8 sessions over 12 weeks) designed specifically for people with kneecap arthritis is effective. In order to understand more about kneecap arthritis, this project will calculate the force on the kneecap and its relationship to pain and other factors, including thigh and hip muscle strength, knee alignments and knee movements.
ENDOGENOUS PAIN RELIEF IN HEALTHY AND OSTEOARTHRITIC PATIENTS
Funder
National Health and Medical Research Council
Funding Amount
$509,926.00
Summary
Pain has a detrimental impact on ones quality of life and a significant financial impact on the community. Given this, there is a substantial effort aimed at developing pain relieving compounds. One way in which our own brain can provide complete pain relief is via a mechanism called diffuse noxious inhibitory control. We currently do not know how this mechanism works and the aim of this investigation is to explore this mechanism in healthy and osteoarthritis patients use human brain imaging.
Anterior Cruciate Ligament Reconstruction (ACLR) And Neuromuscular Training
Funder
National Health and Medical Research Council
Funding Amount
$99,248.00
Summary
Anterior Cruciate Ligament Reconstructive (ACLR) following ACL rupture is a successful surgery that improves stability of the knee joint. However, evidence is emerging that despite undergoing reconstructive surgery, osteoarthritis of the knee joint is prevalent in the proceeding years. The proposed research aims to improve biomechanical abnormalities by providing a neuromuscular intervention. This could lead to a more optimal biomechanical pattern which could reduce the degenerative changes occu ....Anterior Cruciate Ligament Reconstructive (ACLR) following ACL rupture is a successful surgery that improves stability of the knee joint. However, evidence is emerging that despite undergoing reconstructive surgery, osteoarthritis of the knee joint is prevalent in the proceeding years. The proposed research aims to improve biomechanical abnormalities by providing a neuromuscular intervention. This could lead to a more optimal biomechanical pattern which could reduce the degenerative changes occurring within the knee of ACLR patients.Read moreRead less
This research program aims to utilise three new clinical trials to treat pain from osteoarthritis of the knee and hand. These treatments use existing medications, but for new indications. This project will determine if these treatments reduce pain and slow structural changes over two years of treatment. It also has the potential to develop the first treatment for osteoarthritis which changes the natural course of the disease rather than merely treating symptoms.
Does Low Dose Amitriptyline Reduce Pain In Knee Osteoarthritis? A Double Blind, Randomised, Pragmatic, Placebo Controlled Clinical Trial Of Amitriptyline In Addition To Usual Care
Funder
National Health and Medical Research Council
Funding Amount
$413,704.00
Summary
Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.
TreatOA4life (Treat OsteoArthritis4life) – A Sustainable Lifestyle Treatment To Improve Outcomes In Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$181,065.00
Summary
Osteoarthritis (OA), the most common cause of arthritis, was estimated to cost $3.75 billion AUD in 2012. It has no cure or effective treatment and its cost is escalating with the obesity epidemic. Education, weight management and exercise reduce pain and slow the disease process, especially used early in disease. TreatOA4life will provide this treatment in a simple easy to access form in primary care, designed to improve OA outcomes in a self-sustaining fashion from initial diagnosis.