Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
ROLE OF RIP KINASES & IAPs IN MUCOSAL IMMUNE DEFENCE
Funder
National Health and Medical Research Council
Funding Amount
$631,168.00
Summary
Pathogenic bacteria are master manipulators of the inflammatory signalling pathways designed to thwart them. Understanding how they do this will allow us to develop drugs that limit their ability to infect. We have shown that pathogenic bacteria inject a protein called EspL into human cells to promote the destruction of a family of human proteins, called RIP Kinases (RIPK), that co-ordinate the inflammatory response and aim now to discover how EspL causes RIPK degradation and thereby promotes in ....Pathogenic bacteria are master manipulators of the inflammatory signalling pathways designed to thwart them. Understanding how they do this will allow us to develop drugs that limit their ability to infect. We have shown that pathogenic bacteria inject a protein called EspL into human cells to promote the destruction of a family of human proteins, called RIP Kinases (RIPK), that co-ordinate the inflammatory response and aim now to discover how EspL causes RIPK degradation and thereby promotes infection.Read moreRead less
Understanding Virulence In Staphylococcus Aureus And Impacts On Host Response
Funder
National Health and Medical Research Council
Funding Amount
$574,890.00
Summary
Golden Staph remains an important cause of serious infections in Australian patients. New strategies to combat this disease require a better understanding of how Golden Staph causes disease and escapes the natural human response to infection. This study will provide new insights into how Golden Staph causes disease, and provide a platform for developing new strategies to prevent and treat Golden Staph infections.
This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Adaptive learning of spatiotemporal patterns: Development of multi-layer spiking neuron networks using Hebbian and competitive learning. The aim of this project is to develop a method for recognising patterns that change in time. The development of a reliable method that is fast and robust to noise will have wide application in many areas, especially computer speech recognition where timing plays a crucial role. Building-blocks similar to those in the brain (spiking neurons) will be used. Aut ....Adaptive learning of spatiotemporal patterns: Development of multi-layer spiking neuron networks using Hebbian and competitive learning. The aim of this project is to develop a method for recognising patterns that change in time. The development of a reliable method that is fast and robust to noise will have wide application in many areas, especially computer speech recognition where timing plays a crucial role. Building-blocks similar to those in the brain (spiking neurons) will be used. Automatic techniques will be used to teach groups of spiking neurons the differences between sequences of events by adjusting connections between them. The significance of this approach is that it captures information about timing that is missed in existing techniques.Read moreRead less
Adaptive learning in networks of spiking neurons for recognising patterns that change with time. The aim of this project is to develop a method for recognising patterns that change with time. Building-blocks similar to those in the brain (spiking neurons) will be used. Automatic techniques will be developed to teach groups of spiking neurons the differences between sequences of events by adjusting connections between neurons. The significance of this approach is that it captures information abou ....Adaptive learning in networks of spiking neurons for recognising patterns that change with time. The aim of this project is to develop a method for recognising patterns that change with time. Building-blocks similar to those in the brain (spiking neurons) will be used. Automatic techniques will be developed to teach groups of spiking neurons the differences between sequences of events by adjusting connections between neurons. The significance of this approach is that it captures information about timing that is missed in existing techniques. The development of a reliable method that is fast and robust to noise will have wide application in many areas, especially computer speech recognition where timing plays a crucial role.Read moreRead less
Temporal Pattern Learning and Recognition in Neural Systems. This project is relevant to the National Research Priority area of Frontier Technologies and addresses fundamental cross-disciplinary issues of how neural systems learn patterns that change with time, which is at the cutting edge of intelligent processing systems. Applications are in rapidly growing fields of automatic speech processing, robotics, machine learning and intelligent systems, all with applications in areas of economic impo ....Temporal Pattern Learning and Recognition in Neural Systems. This project is relevant to the National Research Priority area of Frontier Technologies and addresses fundamental cross-disciplinary issues of how neural systems learn patterns that change with time, which is at the cutting edge of intelligent processing systems. Applications are in rapidly growing fields of automatic speech processing, robotics, machine learning and intelligent systems, all with applications in areas of economic importance. Application to cochlear implant speech processing will provide benefit for the hearing impaired. The project will provide students with training at an international level within Australia, thus helping ensure Australia maintains and extends its science and technology base into the future.Read moreRead less
Spatial And Temporal Dimensions Of Mu-opioid Receptor Signalling: Implications For The Development Of Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$799,316.00
Summary
The use of morphine as an analgesic is still limited by undesirable side effects such as tolerance. Despite decades of research, the mechanisms behind the development of tolerance are poorly understood. The ? opioid receptor is a protein expressed at the surface of the cells that is the target of morphine. This project will investigate the signalling events triggered by opioids with unprecedented resolution and will aim to elucidate why morphine elicits more tolerance than other opioid drugs.
Function And Inhibition Of Plasmepsin V In Targeting Malaria Virulence Proteins Into Human Erythrocytes
Funder
National Health and Medical Research Council
Funding Amount
$407,845.00
Summary
Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cel ....Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cell.Read moreRead less
Multi-Targeted Inhibition Of An Essential Tetrameric Enzyme From Drug -Resistant Streptococcus Pneumonie.
Funder
National Health and Medical Research Council
Funding Amount
$534,313.00
Summary
Streptococcus pneumoniae is an significant human pathogen which causes several diseases including pneumonia and meningitis. Treatment of infection involves the use of antibiotics such as penecillin, however, resistant strains are now emerging. This project will address the real need to develop new antibiotics targeting this organism. This is essentially a drug discovery project which exploits a novel means to target Streptococcus pneumoniae.