From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect ....From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect-specific flaviviruses affect mosquitoes and this information is vital for informed design of ISF-based interventions. The project will generate new knowledge on functions of noncoding RNAs in ISFs that are hypothesised to have immunomodulatory role in mosquitoes. It will also train students and ECRs.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability ....Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability, and pinpoint strategies for reducing vulnerabilities in the future. The project expects to show how vulnerable citizens in Indonesia can be made more secure, helping to build a more stable and prosperous region.Read moreRead less
A new model of teamwork for Human-Autonomy Teams (HATs). Human-Autonomy Teams (HATs) could potentially enhance most aspects of our daily lives; however, there are key knowledge gaps around HAT functioning and how to achieve optimal HAT performance. This research will apply a novel integration of systems analysis and computational modelling methods to develop, test, and validate a new model of teamwork in HATs. The model will clarify the processes and behaviours that support optimal HAT functioni ....A new model of teamwork for Human-Autonomy Teams (HATs). Human-Autonomy Teams (HATs) could potentially enhance most aspects of our daily lives; however, there are key knowledge gaps around HAT functioning and how to achieve optimal HAT performance. This research will apply a novel integration of systems analysis and computational modelling methods to develop, test, and validate a new model of teamwork in HATs. The model will clarify the processes and behaviours that support optimal HAT functioning, delineate HAT performance measures, and help to identify strategies to optimise HAT performance. The outcomes will provide a basis for future HAT research and ensure that the potential benefits of HATs are realised in areas such as defence, transport, healthcare, manufacturing, and disaster response.Read moreRead less
Information support tools for the trauma patient pathway. Processes such as critical supply chain management, disaster management, and trauma patient pathways need people, resources, and information to be smoothly transferred between jurisdictions, but problems can occur at each handover. This project focuses on the prehospital to hospital patient pathway and aims to develop technologies, devices, and displays to support more effective handover of patients between jurisdictions. The project will ....Information support tools for the trauma patient pathway. Processes such as critical supply chain management, disaster management, and trauma patient pathways need people, resources, and information to be smoothly transferred between jurisdictions, but problems can occur at each handover. This project focuses on the prehospital to hospital patient pathway and aims to develop technologies, devices, and displays to support more effective handover of patients between jurisdictions. The project will conduct field research, design activities, and simulation-based evaluation of prototypes with healthcare professionals. Expected outcomes are designs, technologies, and guidelines that will generalise to other multi-jurisdictional processes. Benefits are safer and more efficient handover processes.Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100082
Funder
Australian Research Council
Funding Amount
$3,450,896.00
Summary
My Air Space: the Science of Buildings that Make us Thrive. Nothing is more necessary in human life than the air we breathe, mostly indoors where air quality has been relatively overlooked. This project aims to deliver new science and technology as a foundation for optimising indoor atmospheres to improve health, wellbeing, and comfort. Expected outcomes include innovative, efficient, low-cost diagnostic sensing of indoor atmospheres and human–space interactions, real-time detection of airborne ....My Air Space: the Science of Buildings that Make us Thrive. Nothing is more necessary in human life than the air we breathe, mostly indoors where air quality has been relatively overlooked. This project aims to deliver new science and technology as a foundation for optimising indoor atmospheres to improve health, wellbeing, and comfort. Expected outcomes include innovative, efficient, low-cost diagnostic sensing of indoor atmospheres and human–space interactions, real-time detection of airborne pathogens and particles that host them, and cost-effective localised conditioning of spaces for comfort at points of actual use. Benefits should be seen in areas of health, productivity, reduced energy use, and new industries for the design, modernising, and operation of buildings across Australia and beyond.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100095
Funder
Australian Research Council
Funding Amount
$378,920.00
Summary
Using systems science to secure the health workforce against climate change. The widespread maldistribution of the Australian health workforce is creating significant health human resource shortages in non-urban areas of need. Climate-related extreme weather events (i.e., heat, droughts, fires, floods) are projected to exacerbate workforce deficiencies in rural regions. This project aims to explore how climate change will impact the future of the rural health workforce through a novel integratio ....Using systems science to secure the health workforce against climate change. The widespread maldistribution of the Australian health workforce is creating significant health human resource shortages in non-urban areas of need. Climate-related extreme weather events (i.e., heat, droughts, fires, floods) are projected to exacerbate workforce deficiencies in rural regions. This project aims to explore how climate change will impact the future of the rural health workforce through a novel integration of computational systems science methods. The project expects to discover new policies to correct the maldistribution and strengthen the resilience of the rural health workforce against climate change impacts. Benefits include a sustained and more adaptable workforce leading to improved health for vulnerable communities.Read moreRead less
Aerosol glassy states promote global warming, airborne toxins and pathogens. This project will improve our understanding of the role played by airborne particles in global climate, pollution and the transmission of influenza, corona virus and the common cold. It will do so by revealing the wider importance of "glassy states" of matter recently revealed in atmospheric aerosols. Glassy states are highly unpredictable quasi solids that abruptly form, interrupting the transition of a liquid to a sol ....Aerosol glassy states promote global warming, airborne toxins and pathogens. This project will improve our understanding of the role played by airborne particles in global climate, pollution and the transmission of influenza, corona virus and the common cold. It will do so by revealing the wider importance of "glassy states" of matter recently revealed in atmospheric aerosols. Glassy states are highly unpredictable quasi solids that abruptly form, interrupting the transition of a liquid to a solid. This interruption invalidates equilibrium assumptions of models of droplets as cloud nuclei and infection vectors. We will develop and validate a numerical tool for predicting glassy state formation and its impact in broad classes of aerosol that include particles critical to cloud formation and infection transmission.Read moreRead less