Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect ....From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect-specific flaviviruses affect mosquitoes and this information is vital for informed design of ISF-based interventions. The project will generate new knowledge on functions of noncoding RNAs in ISFs that are hypothesised to have immunomodulatory role in mosquitoes. It will also train students and ECRs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100710
Funder
Australian Research Council
Funding Amount
$422,492.00
Summary
Beyond Hendra: the significance of viral communities in bat virus spillover. This project aims to address the emerging global health threat posed by zoonotic bat-borne viruses, by determining why bats shed multiple viruses in synchronised pulses. The project expects to identify universal drivers of multi-viral shedding pulses, using Hendra virus as a model system for other bat viruses in Australia and globally. Expected outcomes include insights into the interactions between environmental change ....Beyond Hendra: the significance of viral communities in bat virus spillover. This project aims to address the emerging global health threat posed by zoonotic bat-borne viruses, by determining why bats shed multiple viruses in synchronised pulses. The project expects to identify universal drivers of multi-viral shedding pulses, using Hendra virus as a model system for other bat viruses in Australia and globally. Expected outcomes include insights into the interactions between environmental change, bat ecology, viral dynamics and spillover, prediction of when and where bat viral shedding will most likely occur, and development of new ecological interventions to prevent bat virus spillover in Australia and globally. This will provide significant benefits by pre-empting spillover and global pandemics before they occur.Read moreRead less
Between a hot place & hypoxia: Quantifying fish-kill risk in inland rivers. Native fish populations in Australian ephemeral rivers are highly valued but are subject to widespread decline. During drought waterholes serve as critical refuges for native fish, however thermal extremes and hypoxia (lack of oxygen) have led to regular fish-kill events. Whilst we know the general conditions that lead to fish-kills, we do not have a clear understanding of why some species are more tolerant than others, ....Between a hot place & hypoxia: Quantifying fish-kill risk in inland rivers. Native fish populations in Australian ephemeral rivers are highly valued but are subject to widespread decline. During drought waterholes serve as critical refuges for native fish, however thermal extremes and hypoxia (lack of oxygen) have led to regular fish-kill events. Whilst we know the general conditions that lead to fish-kills, we do not have a clear understanding of why some species are more tolerant than others, or how we can help decision-makers anticipate fish-kill risks. This project will combine laboratory ecophysiology investigations and novel field monitoring techniques to develop a next-generation fish habitat model for stakeholders to use to assess fish-kill risks and plan for restoration. Read moreRead less
How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. ....How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. It also looks at climate anxiety management across generations and climate histories, drawing out pessimistic/optimistic narratives about the future to enable action, resilience, and hope. It will produce an evidence base and photo-voice/documentary resources to help parents and support organisations combat climate anxiety.Read moreRead less
The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) ....The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) in England and Europe from 1600 to 1750, against the backdrop of the rise of Cartesianism. The anticipated outcome is greater awareness of an enduring feminist tradition within the history of philosophy. The expected social benefits include a shift in public thinking about feminist history and women in philosophy.Read moreRead less
Examining scientific, philosophical, and folk perspectives on time=. This project aims to consider three very different physical theories, each of which reconciles quantum mechanics and general and special relativity in a different way. While science is more accessible than ever, we are increasingly faced with a scientific world-view that is antithetical to the way we see the world and experience ourselves in it. This project will consider the tension between the scientific picture of the world ....Examining scientific, philosophical, and folk perspectives on time=. This project aims to consider three very different physical theories, each of which reconciles quantum mechanics and general and special relativity in a different way. While science is more accessible than ever, we are increasingly faced with a scientific world-view that is antithetical to the way we see the world and experience ourselves in it. This project will consider the tension between the scientific picture of the world and our experience of the world, and aims to reconcile the two by bridging the gap between lived experience and scientific findings. The project will provide a range of ways of bridging the tension between these physical theories with our lived experience.Read moreRead less
Reducing plate waste in hotels - which interventions are most effective? This project aims to quantify the comparative effectiveness of belief-based and choice-architecture-based interventions in reducing food waste generated by tourists at hotel buffets. Expected outcomes include: new insights into effective triggers of pro-environmental tourist behaviour; the first empirical data on carbon emissions caused by plate waste in tourism; an automatic plate waste measurement system and benchmarking ....Reducing plate waste in hotels - which interventions are most effective? This project aims to quantify the comparative effectiveness of belief-based and choice-architecture-based interventions in reducing food waste generated by tourists at hotel buffets. Expected outcomes include: new insights into effective triggers of pro-environmental tourist behaviour; the first empirical data on carbon emissions caused by plate waste in tourism; an automatic plate waste measurement system and benchmarking app for monitoring and comparison; and effective practical measures to reduce avoidable food leftovers generated by tourists. This should provide significant benefits by: lowering food cost for the struggling tourism industry, reducing carbon emissions, and contributing to Australia’s aim of halving food waste by 2030.Read moreRead less
Resolving the threat of ocean deoxygenation to coral resilience. This project aims to uncover the role low oxygen plays in shaping healthy corals over space and time. Climate change and land use development are rapidly deoxygenating shallow water coral reefs, yet we have no knowledge of how less oxygen availability affects critical life history factors that govern coral resilience: growth, reproduction, and stress tolerance. This project unites a multidisciplinary team of experts to, for the fir ....Resolving the threat of ocean deoxygenation to coral resilience. This project aims to uncover the role low oxygen plays in shaping healthy corals over space and time. Climate change and land use development are rapidly deoxygenating shallow water coral reefs, yet we have no knowledge of how less oxygen availability affects critical life history factors that govern coral resilience: growth, reproduction, and stress tolerance. This project unites a multidisciplinary team of experts to, for the first time, couple advanced oxygen sensing, metabolic physiology, coral reproductive and stress biology to transform our understanding of oxygen thresholds that are diagnostic of reduced coral competitive fitness across life stages (adults, juveniles, larvae), needed to improve coral reef ecosystem management.Read moreRead less
Reducing global tourism carbon emissions . With over 6 billion vacation trips annually, tourism is a major and fast-growing contributor to climate change. To support a climate-centred tourism policy, this Project aims to construct a world’s first global database that answers three key questions: 1) if tourism carbon footprint increases in direct proportion to its consumption, 2) how quickly tourism can decarbonise emissions, and 3) can tourism deliver better carbon performance than other sectors ....Reducing global tourism carbon emissions . With over 6 billion vacation trips annually, tourism is a major and fast-growing contributor to climate change. To support a climate-centred tourism policy, this Project aims to construct a world’s first global database that answers three key questions: 1) if tourism carbon footprint increases in direct proportion to its consumption, 2) how quickly tourism can decarbonise emissions, and 3) can tourism deliver better carbon performance than other sectors? The outcomes include new theoretical and empirical knowledge about the impacts, drivers, and trade-offs of tourism's carbon emissions. A significant benefit of this Project is to identify mitigation policies that can better balance tourism economic yield and emissions stabilisation.Read moreRead less