Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation p ....Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation products to the Australian community for the treatment of asthma and other diseases, iv) facilitate environmentally friendly technology since powder aerosol delivery does not require any harmful organic solvents to operate.Read moreRead less
Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol a ....Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol administration. Successful development of the technology will not only gain new knowledge in the key area of nanotechnology, but also lead to better inhalation therapy to benefit patients.Read moreRead less
Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung inf ....Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung infection and other serious health problems will benefit from an improved delivery of therapeutic dose at a much reduced cost. The technology is environmentally friendly as powder aerosol delivery does not require any harmful organic solvent to operate.Read moreRead less
High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful developme ....High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful development of the technology will position both Australia and the industry partner to take a lead in the application of this novel technology in pharmaceutical aerosols, and provides better inhalation therapy to benefit patients.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
The elutriation of ultrafine particles according to their density. This study is concerned with exploiting a new and powerful mechanism for separating particles according to their density, with strong potential for recovering and concentrating tens of billions of dollars worth of valuable minerals annually. By coupling the new separation mechanism with a centrifugal force it should be possible to apply gravity separation technology, arguably for the first time, to the recovery of ultrafine parti ....The elutriation of ultrafine particles according to their density. This study is concerned with exploiting a new and powerful mechanism for separating particles according to their density, with strong potential for recovering and concentrating tens of billions of dollars worth of valuable minerals annually. By coupling the new separation mechanism with a centrifugal force it should be possible to apply gravity separation technology, arguably for the first time, to the recovery of ultrafine particles from 200 microns to well below 10 microns, at high separation efficiency, and high feed rates. This study is also ideal for training new researchers, especially at the PhD level, in an area of importance to Australia's economic future. Read moreRead less
Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants. We will create a benign technology for synthesising microfluidic hydrogels to generate artificial vascultures in bone implants. It is a critical step to enable the use of tissue-engineered vital organs, such as bone, heart and kidney in patients with end-stage organ failure. Thicker scaffolds will be possible, as the vasculature will provide nutrients and oxygen for cells to grow into 3D scaffolds. ....Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants. We will create a benign technology for synthesising microfluidic hydrogels to generate artificial vascultures in bone implants. It is a critical step to enable the use of tissue-engineered vital organs, such as bone, heart and kidney in patients with end-stage organ failure. Thicker scaffolds will be possible, as the vasculature will provide nutrients and oxygen for cells to grow into 3D scaffolds. It will promote capacity of Australia for manufacturing global biomaterial products for tissue engineering. We will also develop in-situ imaging analytical protocols for the rapid analysis of broad arrays of functional molecules, with significant bearing on BioMEMS design to develop methods for diagnosis of fatal diseases.Read moreRead less
Nano-engineered catalysts for sustainable fuel production from waste . This project aims to address two major problems simultaneously-reducing the burden of non-recyclable waste currently going to landfill in Australia, and offsetting Australia’s reliance on imported diesel to support industry and transport needs. While approximately 95% of diesel consumed in Australia is imported, vast quantities of carbon-based waste ends up in landfill. Municipal Solid Waste (MSW) is a mixture of plant-based ....Nano-engineered catalysts for sustainable fuel production from waste . This project aims to address two major problems simultaneously-reducing the burden of non-recyclable waste currently going to landfill in Australia, and offsetting Australia’s reliance on imported diesel to support industry and transport needs. While approximately 95% of diesel consumed in Australia is imported, vast quantities of carbon-based waste ends up in landfill. Municipal Solid Waste (MSW) is a mixture of plant-based waste (including food, garden, paper, and wood) and fossil-fuel derived materials (plastics). Using an innovative and environmentally-sustainable catalytic process, the outcomes of this project are aimed alleviating Australia’s dependence on diesel fuel imports and better waste management solutions in Australia.Read moreRead less
Particle classification using a ferrofluid in a non uniform magnetic field. The separation of micron size components of suspensions according to the size and density of the particles is presently an intractable problem. However, by using a magnetized ferrofluid it should be possible to generate unique particle trajectories for each combination of particle size and density. This study investigates the potential of this strategy for separating such particles, laying the foundation for new small-sc ....Particle classification using a ferrofluid in a non uniform magnetic field. The separation of micron size components of suspensions according to the size and density of the particles is presently an intractable problem. However, by using a magnetized ferrofluid it should be possible to generate unique particle trajectories for each combination of particle size and density. This study investigates the potential of this strategy for separating such particles, laying the foundation for new small-scale diagnostic "lab-on a chip" technology that could be used in biotechnology to study whole blood, or in mineral processing to control energy intensive ball mills for mineral particle liberation.Read moreRead less
Use of Parallel Inclined Channels to Enhance Foam Drainage in Ion Flotation. This study is concerned with increasing the rates of foam drainage in flotation processes. The findings will have direct benefit in the field of ion flotation, and will be highly relevant to the flotation of high value minerals worth tens of billions of dollars annually. The Reflux Classifier, a device that employs the Boycott Effect to achieve a significant increase in the effective area of the vessel, will be used. Th ....Use of Parallel Inclined Channels to Enhance Foam Drainage in Ion Flotation. This study is concerned with increasing the rates of foam drainage in flotation processes. The findings will have direct benefit in the field of ion flotation, and will be highly relevant to the flotation of high value minerals worth tens of billions of dollars annually. The Reflux Classifier, a device that employs the Boycott Effect to achieve a significant increase in the effective area of the vessel, will be used. This device has already attracted three national awards in the area of gravity concentration in mineral processing. The study is ideal for training new researchers, especially at the PhD level, given the importance of the field to Australia. Read moreRead less