Functional polymeric nanopores from cyclic peptide templates. This research programme will develop nanotubes prepared through the self-assembly of cyclic peptide/polymer conjugates into functional devices for applications as nanopores. The project will establish the fundamental knowledge required to develop these materials into nanoporous polymeric films and transmembrane channels. The research programme will establish new synthetic routes to the conjugates, ascertain the technique of assembly i ....Functional polymeric nanopores from cyclic peptide templates. This research programme will develop nanotubes prepared through the self-assembly of cyclic peptide/polymer conjugates into functional devices for applications as nanopores. The project will establish the fundamental knowledge required to develop these materials into nanoporous polymeric films and transmembrane channels. The research programme will establish new synthetic routes to the conjugates, ascertain the technique of assembly into nanotubes, with a particular focus on improving the precision with which we achieve structural control, and explore the use of the nanotubes to design nanopores, for applications in the manufacture of nanoporous materials, as antibiotic agents and as biosensors.Read moreRead less
Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will ....Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.Read moreRead less
Study the Utility of Novel Drug Polymer Conjugates. The products likely to arise from the technology described in this proposal could have application in medical, veterinary and agricultural industries. It offers the potential to treat diseases that are at present poorly treated by enabling delivery direct to the diseased organ (e.g. eye - bacterial endophthalmitis). Completion of the project will also assist a fledgling biotech company transition to a development company with a multiple produ ....Study the Utility of Novel Drug Polymer Conjugates. The products likely to arise from the technology described in this proposal could have application in medical, veterinary and agricultural industries. It offers the potential to treat diseases that are at present poorly treated by enabling delivery direct to the diseased organ (e.g. eye - bacterial endophthalmitis). Completion of the project will also assist a fledgling biotech company transition to a development company with a multiple product portfolio, which will have a direct economic benefit to Australia both in terms of potential export earnings and as an employer highly skilled staff. The project will also provide research training and career opportunities for developing Australian based researchers.Read moreRead less
Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of m ....Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of medical conditions, from spinal cord injury through to epilepsy. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less
New generation functional materials for 21st century applications: exploiting the properties of naphthalene diimides. This project melds the expertise of several research groups in the area of fluorescent material development. Based on a family of highly fluorescent molecules, the project will focus on designing new sensors, polymeric materials and molecular switching devices.
Discovery Early Career Researcher Award - Grant ID: DE170100315
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Combinatorial design of multivalent polymers for cell receptor clustering. This project aims to design biologically active multivalent peptide-polymer conjugates. This project will use an enzyme to conduct the reactions in tiny volumes in the open air, and prepare and screen large libraries of different architectures for their ability to kill cancer cell lines through the clustering of death receptor proteins on the cell surface. Such combinatorial techniques have been crucial to the development ....Combinatorial design of multivalent polymers for cell receptor clustering. This project aims to design biologically active multivalent peptide-polymer conjugates. This project will use an enzyme to conduct the reactions in tiny volumes in the open air, and prepare and screen large libraries of different architectures for their ability to kill cancer cell lines through the clustering of death receptor proteins on the cell surface. Such combinatorial techniques have been crucial to the development of small molecule drugs. This project aims to apply this technique to well-defined macromolecules, studying their structure-activity relationships, and could lead ultimately to the generation of lead compounds for therapeutics with high commercial relevance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100104
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Capability for the fabrication and characterisation of mid-infrared photonic materials. The proposed facility will support the development of new glass materials suitable for transmitting and generating light in the mid-infrared spectral region. This research will allow Australia to lead the world in developing new technologies that make use of the mid-infrared region of the electromagnetic spectrum. Particular applications that will flow from this research include the development of new optical ....Capability for the fabrication and characterisation of mid-infrared photonic materials. The proposed facility will support the development of new glass materials suitable for transmitting and generating light in the mid-infrared spectral region. This research will allow Australia to lead the world in developing new technologies that make use of the mid-infrared region of the electromagnetic spectrum. Particular applications that will flow from this research include the development of new optical fibre-based laser sources for defence and surgery, new technologies for detecting and treating cancer, and other in-vivo detection methods.Read moreRead less
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.