Short Duration Hypothermia To Prevent Subsequent Intracranial Pressure Rise.
Funder
National Health and Medical Research Council
Funding Amount
$436,453.00
Summary
Elevated brain pressure after stroke or other forms of brain injury can cause further injury and death. Body cooling to 32-33 C (hypothermia) for 12-24 hours saves lives after some forms of brain injury, but may have major side effects. We found that 2 hours hypothermia has a long-lasting effect preventing pressure elevation. We will determine the best temperature and duration of hypothermia in a stroke model and use imaging to confirm findings in patients, with a view to later human trials.
Tenecteplase Versus Alteplase For Stroke Thrombolysis Evaluation (TASTE) Trial
Funder
National Health and Medical Research Council
Funding Amount
$4,180,030.00
Summary
Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) is an Australian-led international randomised trial designed to generate practice-changing evidence by translating the advanced imaging treatment selection approach used in our previous pilot studies. TASTE aims to confirm the superiority of the new-generation clot-dissolving agent, tenecteplase, over the standard agent, alteplase, in the broad group of stroke patients eligible for acute clot-dissolving treatment.
Triple Therapy Prevention Of Recurrent Intracerebral Disease EveNts Trial (TRIDENT)
Funder
National Health and Medical Research Council
Funding Amount
$5,256,292.00
Summary
Acute intracerebral haemorrhage (ICH) is a serious form of stroke. Survivors of ICH are at high risk of repeat events. Blood pressure lowering is a very important to prevent repeat events but data shows blood pressure is poorly controlled in these patients. In this research we investigate whether an approach that uses a 'triple pill' strategy (3 low dose BP drugs in one pill) in ICH patients with mild to moderate hypertension can decrease major cardiovascular events.
Developing A New Glaucoma Surgery Using Precision Ablation Of The Trabecular Meshwork And Inner Wall Of Schlemm’s Canal
Funder
National Health and Medical Research Council
Funding Amount
$653,606.00
Summary
Glaucoma is a major sight threatening disease in our community, affecting an estimated 60 million people worldwide. This project investigates a new laser based method for reducing intraocular pressure, the major risk factor in glaucoma. The novel approach is to create a selectable number of drainage channels for excess fluid in the eye to drain away, thereby restoring normal intraocular pressure.
Characterising A Newly Identified Mechanism Causing Elevation Of Intracranial Pressure After Acute Neurological Injury
Funder
National Health and Medical Research Council
Funding Amount
$510,905.00
Summary
Our group discovered that increased pressure on the brain (intracranial pressure – ICP) may be more common and important than has been recognised following stroke, and potentially other brain disorders. We also identified a simple potential therapy, short-duration body cooling, which completely prevents the pressure rise. In this project we will characterise the ICP rise, identify its molecular trigger and determine the best method of body cooling tor use in clinical trials in stroke patients.
EXTEND-IA Randomized Trial Of Intra-arterial Clot Retrieval In Ischemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$764,534.00
Summary
Most strokes are caused by a blocked blood vessel in the brain. Current treatments to dissolve the blockage improve recovery for many patients but often fail to unblock larger brain arteries. The EXTEND-IA trial will use advanced brain imaging to identify patients who have the most to gain if the blocked artery can be re-opened. The trial will test whether a new minimally invasive clot removal procedure performed after standard clot-dissolving treatment improves recovery after stroke.
Trends And Determinants Of Blood Pressure In Chinese Children And Adolescents During The Recent Obesity Epidemic: A Repeated Cross-sectional Study Over 25 Years
Funder
National Health and Medical Research Council
Funding Amount
$349,259.00
Summary
Over the last 25 years, the prevalence of overweight and obesity increased over 9 times among Chinese children and adolescents. The aims of this project are to assess the trends of blood pressure levels in children during the period of obesity epidemic, and to estimate the effects of obesity and other factors on the trends of blood pressure levels. In this repeated cross-sectional study, we will analyse the data of six surveys collected over a period of 25 years with over 1.4 million participant ....Over the last 25 years, the prevalence of overweight and obesity increased over 9 times among Chinese children and adolescents. The aims of this project are to assess the trends of blood pressure levels in children during the period of obesity epidemic, and to estimate the effects of obesity and other factors on the trends of blood pressure levels. In this repeated cross-sectional study, we will analyse the data of six surveys collected over a period of 25 years with over 1.4 million participants.Read moreRead less
Treatment for high blood pressure was once thought to be life-long. However, there is irrefutable experimental evidence that the right treatments, given in the right circumstances can lower blood pressure for life even after treatment is stopped. The goal of this project is to find ways in which the right people might be identified with the hope of saving drug costs, side effects and lives at the same time.
Modelling Of Clinic And Ambulatory Blood Pressure On Cardiovascular Risk And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$133,957.00
Summary
Whilst ambulatory blood pressure monitoring data has been shown to be a good predictor of cardiovascular events, there remains controversy as to its utility in clinical practice. This project will use data from existing population and clinical cohort studies to examine the role of ambulatory blood pressure in risk assessment and hypertension management in Australia and around the globe. The findings are likely to have a major impact on clinical guidelines for hypertension management.
Interactions Between The Serotonin Transporter And Sympathetic Nervous Activation In Patients With Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
Funder
National Health and Medical Research Council
Funding Amount
$527,109.00
Summary
There is evidence that patients with major depressive disorder (MDD) are at increased risk of developing heart disease. While the mechanisms responsible remain unknown we have previously demonstrated that cardiac sympathetic nervous activity in patients with MDD follows a bimodal distribution, with values in some patients being extraordinarily high. In this project we will determine the physiological consequences of sympathetic activation in patients with MDD.