Preventing The Transition From Acute To Chronic Pain. The Role Of Neural And Non-neural Factors.
Funder
National Health and Medical Research Council
Funding Amount
$2,998,900.00
Summary
Pain following injury usually dissipates as the injury heals, however in some individuals it persists and lasts for years. Chronic pain is extremely difficult to treat, particularly that which originates from a damaged nerve. One of the roadblocks in developing effective treatments is our limited understanding of the pathophysiology. The overall aim of this proposal is to address this gap and determine the processes that occur in the brain that results in acute pain transitioning to chronic.
I am a glial-vascular biologist determining the cellular and molecular mechanisms of vessel formation in the retina and choroid. These studies are undertaken during normal developmental and various experimental models of pathological neovascularisation. A
Using High-throughput Genomics To Reveal The Deleterious Genetic Changes That Underlie Paediatric Leukoencephalopathies
Funder
National Health and Medical Research Council
Funding Amount
$1,003,712.00
Summary
There has been an explosion of high-throughput DNA sequencing technologies in the past five years, which have the potential to completely revolutionise medicine and scientific research. Here we present a series of studies showing the successful application of this technology to children with genetic disorders of the central nervous system. This proposal seeks to expand this study to a large cohort of similarly affected paediatric patients.