A Novel Mechanism For Manipulation Of Peripheral Glucose Utilization In Patients With Type 2 Diabetes Mellitus.
Funder
National Health and Medical Research Council
Funding Amount
$283,500.00
Summary
Significance: Over 600,000 Australians have type 2 diabetes (approximately half are undiagnosed) and it is estimated that this number will increase substantially to 10% of the adult population over the next 10 years. At the conclusion of this grant we expect to understand whether specific signalling molecules might plausibly represent the basis of a novel therapeutic approach to control blood glucose. If successful, this work could contribute to improved metabolic control and prevention of diabe ....Significance: Over 600,000 Australians have type 2 diabetes (approximately half are undiagnosed) and it is estimated that this number will increase substantially to 10% of the adult population over the next 10 years. At the conclusion of this grant we expect to understand whether specific signalling molecules might plausibly represent the basis of a novel therapeutic approach to control blood glucose. If successful, this work could contribute to improved metabolic control and prevention of diabetic complications through new blood glucose lowering agents. Hypotheses: Muscle is the major site of glucose disposal in the body and the two most relevant stimuli for glucose uptake into muscle are insulin and muscle contraction (exercise). The insulin pathway is impaired in patients with type 2 diabetes leading to high blood glucose and complications. Glucose uptake in response to exercise however appears to be normal in patients with type 2 diabetes. Indeed we have evidence to suggest that this pathway may compensate for impaired insulin action in type 2 diabetes. We hypothesise that molecules activated by contraction (exercise) may be useful as therapies to improve resting glucose control in type 2 diabetic patients. Aims: We plan a series of three studies to examine whether glucose uptake may be improved both acutely and chronically at rest by an agent implicated in exercise mediated glucose uptake.Read moreRead less
Insulin Resistance In Peripheral Artery Disease: Clinical Significance And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
This project seeks to improve our understanding and treatment of peripheral artery disease – a condition caused by narrowing/blockages in arteries that supply the legs. Peripheral artery disease affects ~15% of adults >40 years and often causes severe, disabling leg pains during walking. Building on recent findings that peripheral artery disease shares some similar characteristics to type 2 diabetes (“insulin resistance”), a common anti-diabetes drug will be trialled as a potential new strate ....This project seeks to improve our understanding and treatment of peripheral artery disease – a condition caused by narrowing/blockages in arteries that supply the legs. Peripheral artery disease affects ~15% of adults >40 years and often causes severe, disabling leg pains during walking. Building on recent findings that peripheral artery disease shares some similar characteristics to type 2 diabetes (“insulin resistance”), a common anti-diabetes drug will be trialled as a potential new strategy to alleviate these leg pains.Read moreRead less