The main purpose of this study is to understand how airborne fungi affect asthmatics who are allergic to them. Fungi or moulds release large numbers of spores into the air that are inhaled. In many cases fungal spores outnumber other particles that carry allergen, such as pollens or cat dander, by 100 to 1. This makes fungi the most common potential allergen in the environment. Fungi have been associated with respiratory diseases including fungal sinusitis, asthma, rhinitis, allergic alveolitis ....The main purpose of this study is to understand how airborne fungi affect asthmatics who are allergic to them. Fungi or moulds release large numbers of spores into the air that are inhaled. In many cases fungal spores outnumber other particles that carry allergen, such as pollens or cat dander, by 100 to 1. This makes fungi the most common potential allergen in the environment. Fungi have been associated with respiratory diseases including fungal sinusitis, asthma, rhinitis, allergic alveolitis and sick building syndrome. Largely due to their diversity and complexity, allergenic fungi have not been well studied and the ways in which individuals vary when inhaling spores is not known. Unlike other allergenic particles, it is unlikely that fungal spores release their allergen as soon as they are inhaled because we have shown in earlier in vitro studies that fungi continue to release allergen over time and this is likely to be the case when they are inhaled. Our laboratory has developed two new techniques that allow us to measure how many spores people inhale and whether they are allergic to them. This study will use these tools to detect and identify the important allergenic fungi involved in domestic and outdoor exposure of asthmatics, the degree of contribution to the total allergen load to which subjects are exposed and identify in what conditions fungi are the causal agents in location-specific symptoms. This study will also investigate allergen production of fungi in situ in the human nose, which will have application in allergic sinusitis and asthma amongst other respiratory diseases. We will investigate how readily allergenic spores germinate in the nose and under what conditions they release allergen.Read moreRead less
Communication Of Genetic Information In Families: A Randomised Controlled Trial Of A Genetic Counselling Intervention.
Funder
National Health and Medical Research Council
Funding Amount
$359,728.00
Summary
The amount of genetic testing information available to Australians has exploded as a result of the human genome project. Our multi-disciplinary team will investigate the most acceptable and feasible way for important genetic information to be transmitted in families. This study will be a world first trial of a genetic counselling intervention which aims to help patients and health professionals communicate life-changing information in families where there is a serious genetic condition.
Quantitiative Assessment Of Solar UV Exposure For Vitamin D Synthesis In Australian Adults
Funder
National Health and Medical Research Council
Funding Amount
$1,162,536.00
Summary
This research program will add significantly to our current scientific understanding of the dual health outcomes of UV exposure (Vitamin D and skin cancer) . This project is in line with Australia's R and D Priorities, in that it will result in direct and indirect social and economic benefits to Australia by applying the scientific knowledge gained through this research to develop public health initiatives to improve some of Australia's most significant and costly health problems.
Can Sawfish Bycatch Within The NPF Be Mitigated Using An Electric Field?
Funder
Fisheries Research and Development Corporation
Funding Amount
$113,468.11
Summary
The Northern Prawn Fishery (NPF) is the largest Australian prawn fishery and the most valuable Commonwealth managed fishery. Annual gross value of production of the fishery was valued at $115.2 million in 2014. In recent decades, the incidental take of bycatch species has become an important issue in trawl fisheries worldwide. Impacts of fishing activities on the marine environment, including bycatch interactions are heavily scrutinised by organisations assessing the sustainability of fisheries ....The Northern Prawn Fishery (NPF) is the largest Australian prawn fishery and the most valuable Commonwealth managed fishery. Annual gross value of production of the fishery was valued at $115.2 million in 2014. In recent decades, the incidental take of bycatch species has become an important issue in trawl fisheries worldwide. Impacts of fishing activities on the marine environment, including bycatch interactions are heavily scrutinised by organisations assessing the sustainability of fisheries such as the MSC. Various Threatened, Endangered and Protected (TEP) species are still regularly caught by the fishery, including sawfishes. All four sawfish species caught within the NPF are listed on the Convention on International Trade in Endangered Species (CITES) Appendix I and the Convention of Migratory Species (CMS) Appendices I & II. Within Australia, three species are listed as Vulnerable, and all four species are listed as Migratory on the EPBC Act 1999.
Sawfishes are among the most threatened family of marine fishes and the most threatened family of cartilaginous fishes (Dulvy et al 2014). Incidental capture, particularly in trawls and gillnets, is the primary threat to sawfishes (Harrison and Duly 2014). Based on a risk assessment of the bycatch species in the NPF, all sawfishes have been identified as ‘at risk’ to trawling and least likely to be sustainable from prawn trawl fishing. A bycatch sustainability assessment also showed little change in catches of sawfishes as a result of the introduction of TEDs into the commercial fleet. The threatened status of sawfishes, vulnerability to fisheries, ongoing catches, and the inefficiency of current bycatch reduction devices to reduce sawfish bycatch suggest an urgent need for the development of new bycatch reduction devices to minimise interactions with fishing gear. This will also have the benefit of improving crew safety on the vessels as the removal of sawfish entangled in the nets is quite dangerous.
Objectives: 1. Assess whether sawfish behaviourally respond to electric fields as measured by reaction from a stationary position 2. Compare sawfish behavioural response across three fields of different characteristics Read moreRead less