I am a clinical scientist translating basic science findings into clinical science questions and answers that impart better understanding and management of pain and painful disease.
Social Aspects Of Amputation Among An Aging Population In Urban And Rural Victoria
Funder
National Health and Medical Research Council
Funding Amount
$251,742.00
Summary
In recent years, social scientists have shown increasing interest in how individual and social structural factors inter-relate to produce wellbeing. An associated interest has been the role of social networks and social support for individuals with chronic disease, enabling them to manage ongoing illness or impairment, live fulfilling lives and experience wellbeing. To explore these issues in an Australian context, this project focuses on people who have had amputations from trauma, advanced dis ....In recent years, social scientists have shown increasing interest in how individual and social structural factors inter-relate to produce wellbeing. An associated interest has been the role of social networks and social support for individuals with chronic disease, enabling them to manage ongoing illness or impairment, live fulfilling lives and experience wellbeing. To explore these issues in an Australian context, this project focuses on people who have had amputations from trauma, advanced disease (e.g. cancer) or complications of chronic disease (e.g. diabetes). The study aims to increase our understanding of how people live with particular diseases and health conditions, the impact of these conditions on body image, self-esteem, social relationships and societal participation, and how structural, contextual and environmental factors affect individual functioning and disability. By including people of different gender, ethnicity, age and area of residence, the study is concerned with how life circumstances and socialization (including ideas of gender) influence outcome. The findings will contribute to our knowledge of adaptation and provide information relevant to improved care for people from different backgrounds. The study is significant because of the increase in chronic disease (relative to infectious disease) in contemporary industrialised societies, particularly with an aging population. The policy context of this work is government interest in maximising the independence and wellbeing of people who are aged and-or with chronic disease, while minimising the economic costs. The research is also significant to international agencies and consumer organisations concerned with reducing discrimination against and inequality of people with impairments. The study will contribute to the WHO classification of disability, and efforts to promote and protect the rights and dignity of persons with disabilities.Read moreRead less
The Role Of SOX14 In Limb Development And Human Limb Defects.
Funder
National Health and Medical Research Council
Funding Amount
$257,606.00
Summary
Little is known about the mechanisms that control limb development. We have discovered a new gene which is active in the developing limb of the embryo. This study will provide information on how this new gene controls the development of the limb. Limb defects occur in 1 in 1,000 new-born babies. We believe the absence of our newly discovered gene may be responsible for some of these limb defects. Ultimately, this fundamental knowledge may lead to improved pre-natal diagnosis and better treament ....Little is known about the mechanisms that control limb development. We have discovered a new gene which is active in the developing limb of the embryo. This study will provide information on how this new gene controls the development of the limb. Limb defects occur in 1 in 1,000 new-born babies. We believe the absence of our newly discovered gene may be responsible for some of these limb defects. Ultimately, this fundamental knowledge may lead to improved pre-natal diagnosis and better treament for limb abnormalities.Read moreRead less
Dissecting The Role Of Hedgehog Signalling In Chondrogenesis And Skeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$408,739.00
Summary
There are close to 400 inherited disorders that affect how the skeleton develops, as well as a range of injury and age-related skeletal defects. There is much interest in treating such abnormalities with artificial bone grown outside the body. In order to achieve this aim we must understand all of the processes involved in producing and maintaining bone within the body. We are using both mouse and cell culture models of skeletal development to increase our understanding of these processes.
Hedgehog Signalling In Limb And Craniofacial Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$494,544.00
Summary
Anomalies of the face and limbs are amongst the most common features of human birth defects, and their frequent association suggests that the same genes are involved in governing the development of the limbs and face during embryogenesis. We have used a genomics-based approach to identify genes involved in limb development based on their alteration in a mouse model which develops extra fingers and toes. Defects in this mouse result from changes in Gli3, a gene which is known to be important in b ....Anomalies of the face and limbs are amongst the most common features of human birth defects, and their frequent association suggests that the same genes are involved in governing the development of the limbs and face during embryogenesis. We have used a genomics-based approach to identify genes involved in limb development based on their alteration in a mouse model which develops extra fingers and toes. Defects in this mouse result from changes in Gli3, a gene which is known to be important in both limb and face development. Based on the organs in which our genes of interest are active, we believe that they will also play key roles in embryonic development of the limbs, face and other organs. We now plan to investigate the regulation of a subset of these genes based on analysis in mouse models of limb and face development. In addition, we have chosen to further analyse the function of a completely novel gene we have identified which our preliminary studies suggest may play a role in the normal development of the lip and palate. These studies have the potential to shed light on the processes governing how organs develop, as well as on the molecular basis of common birth defects such as polydactyly (extra fingers and toes) and cleft palate.Read moreRead less