Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored ....Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored to selectively kill microbes with reduced likelihood of developing resistance by using synergies between inorganic nanoparticles and antimicrobial peptides. This technology could be used to prevent infections and biofilms on surfaces in a wide range of future applications, such as medical / veterinary devicesRead moreRead less
High-load powder dispersion and aerosol delivery: an integrated approach. This project aims to develop a novel design toolbox that can accurately predict dispersion performance of a range of powder systems for high-dose inhaler devices. The project expects to provide the pharmaceutical industry with a cornerstone technology to facilitate the design and optimisation of new powder delivery devices. Outcomes are expected to include new knowledge on powder dispersion behaviour that can be applied to ....High-load powder dispersion and aerosol delivery: an integrated approach. This project aims to develop a novel design toolbox that can accurately predict dispersion performance of a range of powder systems for high-dose inhaler devices. The project expects to provide the pharmaceutical industry with a cornerstone technology to facilitate the design and optimisation of new powder delivery devices. Outcomes are expected to include new knowledge on powder dispersion behaviour that can be applied to various industry sectors, including the environmental, bulk chemical and food industries where the majority of products are in powder form. This knowledge will provide significant benefits to industry through provision of a toolkit that can be used to improve final powder-based product quality.Read moreRead less
A novel approach for the real-time measurement of aerosol surface area. This project aims to develop an innovative optical tomography technology capable of direct and real-time measurement of the surface area of airborne particles. By coupling advanced laser diagnostic tools with physiological models and in vitro characterisation techniques, this project will determine the hitherto unknown fundamental and critical relationships between the surface area of an aerosol and its dissolution when deli ....A novel approach for the real-time measurement of aerosol surface area. This project aims to develop an innovative optical tomography technology capable of direct and real-time measurement of the surface area of airborne particles. By coupling advanced laser diagnostic tools with physiological models and in vitro characterisation techniques, this project will determine the hitherto unknown fundamental and critical relationships between the surface area of an aerosol and its dissolution when delivered to a target. The Project’s outcomes will enable aerosol device manufacturers to develop and market significantly more advanced and highly specific products, thus conferring a competitive advantage.Read moreRead less
Particle transport in the human upper airway. This project aims to determine the fundamental mechanisms that drive particle transport in physiologically realistic human airways. Through use of novel magnetic resonance imaging and laser diagnostic techniques, the project expects to transform our ability to develop effective and validated predictive capabilities for particle transport in physiologically accurate geometries. The project outcomes are expected to enable unprecedented definition of ho ....Particle transport in the human upper airway. This project aims to determine the fundamental mechanisms that drive particle transport in physiologically realistic human airways. Through use of novel magnetic resonance imaging and laser diagnostic techniques, the project expects to transform our ability to develop effective and validated predictive capabilities for particle transport in physiologically accurate geometries. The project outcomes are expected to enable unprecedented definition of how particles are transported in human airways as a function of breathing profiles, particle properties and morphology.Read moreRead less
Perfect particles: Accurate breakage predictions by 3D printing of granules. Granule breakage of micro-structured specialty products impedes manufacturing and degrades product performance. Predictive breakage models have had limited success as each granule has a unique structure. Differences between the model predictions and experimental breakage test results could be due to inaccurate models or irreproducible experimental results due to granule structure differences. This project is expected to ....Perfect particles: Accurate breakage predictions by 3D printing of granules. Granule breakage of micro-structured specialty products impedes manufacturing and degrades product performance. Predictive breakage models have had limited success as each granule has a unique structure. Differences between the model predictions and experimental breakage test results could be due to inaccurate models or irreproducible experimental results due to granule structure differences. This project is expected to be the first ever application of three-dimensional printing for reproducible breakage testing. The project aims to: create the first ever multiple identical copies of complex granules using polyjet three-dimensional printing; model and experimentally measure granule breakage; and develop sophisticated Digital Elevation Models of granule breakage for practical use in industry.Read moreRead less
Epitaxial Stacking of Nanoporous Nanosheets for Next-generation Membranes. The project aims to develop high-precision selective membranes which are urgently needed in Australian key industries for solute-solute separation by constructing vertically-aligned and chemically-tailorable nanochannels using two-dimensional porous nanosheets as building blocks. The project expects to generate advanced knowledge in the areas of nanosheet synthesis and functionalisation, membrane design and fabrication, s ....Epitaxial Stacking of Nanoporous Nanosheets for Next-generation Membranes. The project aims to develop high-precision selective membranes which are urgently needed in Australian key industries for solute-solute separation by constructing vertically-aligned and chemically-tailorable nanochannels using two-dimensional porous nanosheets as building blocks. The project expects to generate advanced knowledge in the areas of nanosheet synthesis and functionalisation, membrane design and fabrication, selective transport of solutes and applications. The membranes developed in the project should make existing separation processes more effective and sustainable and advance emerging applications in pharmaceutical, dairy and mining industries, providing significant economic and environmental benefits to Australia.Read moreRead less
Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of ....Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of new methods to optimise particle deposition, development of tunable powder formulations, as well as definition of particle-surface interaction mechanisms in flows. The project should provide significant benefits to particle systems for applications ranging from additive manufacturing to aerosol delivery.Read moreRead less
Engineered nanoporous materials and composites having hierarchical structures by emulsion templating. The project aims to develop new and flexible emulsion-templated processes capable of constructing novel nanoporous materials with hierarchical structures. The project has the potential to revolutionise current approaches for making porous materials, and the outcomes will enhance Australia's ability in frontier technologies and advanced materials.
Industrial biotechnology for the manufacture of alkaloid pharmaceuticals. Drugs that treat opioid dependence and overdose are increasingly needed but their manufacture is difficult, inefficient and expensive. This project aims to develop enzymatic N-demethylation as a simpler and more sustainable approach to the manufacture and modification of opioid antagonists, alkaloids and other drug targets. It will increase our understanding of enzymatic N-demethylation and address engineering and biotechn ....Industrial biotechnology for the manufacture of alkaloid pharmaceuticals. Drugs that treat opioid dependence and overdose are increasingly needed but their manufacture is difficult, inefficient and expensive. This project aims to develop enzymatic N-demethylation as a simpler and more sustainable approach to the manufacture and modification of opioid antagonists, alkaloids and other drug targets. It will increase our understanding of enzymatic N-demethylation and address engineering and biotechnology challenges to improve yield and product isolation and concentration. Improvements in drug manufacturing processes will assist drug affected communities and industry will benefit from value adding, greater market share and flexibility, increased innovation and de-risked processes and new products. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100174
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and ind ....Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and industry.Read moreRead less