Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natur ....Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natural solvents to replace the volatile organic compound (VOC) fossil fuels based solvents used in the current process. Due to environmental and health concerns associated with VOCs the development of alternative solvents will be of great benefit to not only GSK but a range of other processing industries that also use VOC based solvent extraction processes.Read moreRead less
Advanced hierarchical materials for separation applications. The proposed project represents an international collaboration between Monash University and Fudan University and builds on the research strengths within these two Institutions in nano-materials research and applications. The proposed research will lead to a new class of materials for use in the chemical and biological industries, making their operation more efficient and permitting new separations to be performed. The research will ....Advanced hierarchical materials for separation applications. The proposed project represents an international collaboration between Monash University and Fudan University and builds on the research strengths within these two Institutions in nano-materials research and applications. The proposed research will lead to a new class of materials for use in the chemical and biological industries, making their operation more efficient and permitting new separations to be performed. The research will also pioneer new techniques for use in nano-engineering materials and falls within one of Australia's National Research Priorities: Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Modelling of Nitric Oxides and Carbon Monoxide Emissions from Bagasse-Fires Boilers. The project aims to develop computational models to predict emissions of nitric oxides and carbon monoxide from sugar-mill boilers burning bagasse. Bagasse combustion does not contribute to greenhouse gas emissions and clean and efficient combustion of this fuel has become very important for the sugar industry and for Australia. The project combines the opportunity of direct boiler measurements by SRI with the m ....Modelling of Nitric Oxides and Carbon Monoxide Emissions from Bagasse-Fires Boilers. The project aims to develop computational models to predict emissions of nitric oxides and carbon monoxide from sugar-mill boilers burning bagasse. Bagasse combustion does not contribute to greenhouse gas emissions and clean and efficient combustion of this fuel has become very important for the sugar industry and for Australia. The project combines the opportunity of direct boiler measurements by SRI with the modelling expertise at the University to develop combustion-kinetics models for these species. The models will be incorporated into the previously developed computational fluid dynamics - combustion code of the furnace to give the capability of emission prediction as a function of burner operating conditions and fuel parameters.Read moreRead less
Detailed understanding of the behaviour of soot in, and emission from, turbulent flames and fires. While combustion processes involving soot have been widely employed for many years, their great complexity puts them beyond present capacity to understand or model reliably. Within a flame, soot plays an important role in radiant heat transfer, and hence in energy efficiency. Beyond a flame, soot can either be emitted as an unwanted air pollutant or as a desirable source of nano-particles, dependin ....Detailed understanding of the behaviour of soot in, and emission from, turbulent flames and fires. While combustion processes involving soot have been widely employed for many years, their great complexity puts them beyond present capacity to understand or model reliably. Within a flame, soot plays an important role in radiant heat transfer, and hence in energy efficiency. Beyond a flame, soot can either be emitted as an unwanted air pollutant or as a desirable source of nano-particles, depending on the application. The benefits to society from improved understanding and predictive capability include reduced air pollution, improved health and safety, increased efficiency in the utilisation of both fossil and alternative fuels, the support of the rapidly growing sector employing carbon nano-particles and increased fire safety. Read moreRead less
Innovative zero-energy membrane technologies to reduce water consumption in the dairy industry. The Australian dairy industry not only plays a critical role in our way of life, but processed dairy products contribute to 12% or $3.27b to Australia's export revenue. It has learnt to adapt to changing market demands through innovative membrane technologies, but now energy and water are key issues. This project aims to reduce water consumption in dairy processing by treating waste streams using nove ....Innovative zero-energy membrane technologies to reduce water consumption in the dairy industry. The Australian dairy industry not only plays a critical role in our way of life, but processed dairy products contribute to 12% or $3.27b to Australia's export revenue. It has learnt to adapt to changing market demands through innovative membrane technologies, but now energy and water are key issues. This project aims to reduce water consumption in dairy processing by treating waste streams using novel membrane processes including membrane distillation. The energy is supplied from low grade waste heat, offsetting the need to supply more power to the plant. Reducing the need for water in a zero-energy way will ensure the thriving dairy industry remains cost competitive and an integral part of Australia's culture and economy.Read moreRead less
Innovative strategy for salt management and water recovery from newsprint mill effluent using membrane processes. Newsprint mills are a major employer in regional Australia. The mills are located in environmentally sensitive areas, consume large quantities of water and return high levels of salt to the environment. To remain competitive the newsprint industry, like all industries in regional Australia must develop new strategies for water recycling and salt management. Successful execution of t ....Innovative strategy for salt management and water recovery from newsprint mill effluent using membrane processes. Newsprint mills are a major employer in regional Australia. The mills are located in environmentally sensitive areas, consume large quantities of water and return high levels of salt to the environment. To remain competitive the newsprint industry, like all industries in regional Australia must develop new strategies for water recycling and salt management. Successful execution of this project will minimize water consumption in newsprint production, mitigate the effects of increased sodicity in soils irrigated with mill effluent and accelerate the commercial development a hydrophobic microporous membrane for water recycling and salt removal in environmentally sensitive areas of inland Australia.Read moreRead less
The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (th ....The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (the fibres from skins) to overcome this problem, and it will also be possible to dry sticky materials using material from the fruit itself, rather than additives such as maltodextrin.Read moreRead less
A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boo ....A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boost skin healing rate. This knowledge may ultimately be used to develop wound dressings that maximise healing rate for various skin defects such as chronic wounds and decrease health care costs.Read moreRead less
Granulation of hydrophobic powders: design and control of granule structure. This unique project will further enhance Australia's established world-class excellence in granulation research, and will assist in setting up a new school of excellence in granulation at Monash University. The innovative use of normally problematic material properties to produce 'designer granules' is a clear example of a 'Frontier Technologies' that can be used to develop 'Advanced Materials' for the next generation o ....Granulation of hydrophobic powders: design and control of granule structure. This unique project will further enhance Australia's established world-class excellence in granulation research, and will assist in setting up a new school of excellence in granulation at Monash University. The innovative use of normally problematic material properties to produce 'designer granules' is a clear example of a 'Frontier Technologies' that can be used to develop 'Advanced Materials' for the next generation of agricultural, food and pharmaceutical industries, particularly for delivery of hydrophobic drugs. The innovative ideas presented in this proposal are expected to provide multiple opportunities for collaboration with national and international research institutions and pharmaceutical companies. Read moreRead less