Targeting particulate carriers to epithelial M cells. This project aims to develop and validate an advanced in vitro model of the human intestinal epithelium. The intestine-on-chip model should enable mechanistic studies of the uptake of nano- and micron-size particles by intestinal cells and deliver new insights into the way particulate carriers can be specifically targeted and transported across the intestinal epithelium. Project knowledge and technology are anticipated to generate new commerc ....Targeting particulate carriers to epithelial M cells. This project aims to develop and validate an advanced in vitro model of the human intestinal epithelium. The intestine-on-chip model should enable mechanistic studies of the uptake of nano- and micron-size particles by intestinal cells and deliver new insights into the way particulate carriers can be specifically targeted and transported across the intestinal epithelium. Project knowledge and technology are anticipated to generate new commercialisation opportunities in the oral delivery industry and ultimately, should drive the development of efficient oral formulations for biologics. The model should also reduce the need for animal studies.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Engineering Hybrid Materials with Functional Bioactivity in the GI Tract. This project aims to use an advanced particle engineering approach to develop novel biomaterials with multifunctional activities in the gastrointestinal tract. The project expects to generate new fundamental knowledge of the key interfacial processes that control digestion and identify new pathways for modulating gut microbiome composition. By establishing structure-activity relationships through mechanistic in vitro and i ....Engineering Hybrid Materials with Functional Bioactivity in the GI Tract. This project aims to use an advanced particle engineering approach to develop novel biomaterials with multifunctional activities in the gastrointestinal tract. The project expects to generate new fundamental knowledge of the key interfacial processes that control digestion and identify new pathways for modulating gut microbiome composition. By establishing structure-activity relationships through mechanistic in vitro and in vivo models, the knowledge gain will help guide material design for optimised bioactivity. Technology transfer of the lead formulation through quality by design manufacturing practice is anticipated to position the industry partner for future commercial opportunities within the nutraceutical sector.Read moreRead less
Emerging from the shadows: the evaluation of intervention strategies to reduce social isolation amongst the aged. Social isolation imposes a high cost on affected individuals and the community at large. This project will determine what interventions work in addressing social isolation amongst the older population.
Creative Tropical City: Mapping Darwin's Creative Industries. This research will improve our knowledge and understanding of the creative industries in Darwin. It will provide a strong evidence base for the development of policy options for growing the creative industries in Darwin. And it will interrogate national and international creative industry policy frameworks for their applicability to Darwin.
Young people's understandings of the relation between work, the labour market and education: Their origins and effects. Young people's pathways between school and work have become much more diverse and complex than in the past. Yet the impact of family background on their education and employment outcomes has hardly changed. This project focuses on young people's perceptions of the relation between work, education and the labour market and the pathways open to them. Taking account of recent m ....Young people's understandings of the relation between work, the labour market and education: Their origins and effects. Young people's pathways between school and work have become much more diverse and complex than in the past. Yet the impact of family background on their education and employment outcomes has hardly changed. This project focuses on young people's perceptions of the relation between work, education and the labour market and the pathways open to them. Taking account of recent major changes in the youth labour market, the research aims to understand the role of these perceptions in shaping young people's choices and pathways, how these vary according to social background and experience, and how they affect employment outcomes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668334
Funder
Australian Research Council
Funding Amount
$158,844.00
Summary
Australian Policy Online Development Project. Australian Policy Online provides easy access to a large selection of research reports, papers and articles from centres and institutes throughout Australia. In 2006, the scope of APO's listings and its related research resources will be significantly broadened, increasing the value of the site to its users, including researchers in universities and the public service, journalists, teachers and students. Australia's relations with its neighbours in S ....Australian Policy Online Development Project. Australian Policy Online provides easy access to a large selection of research reports, papers and articles from centres and institutes throughout Australia. In 2006, the scope of APO's listings and its related research resources will be significantly broadened, increasing the value of the site to its users, including researchers in universities and the public service, journalists, teachers and students. Australia's relations with its neighbours in Southeast Asia will be a particular focus of this expansion, and the APO Briefings series of short, topical books will provide an additional, innovative publishing option for researchers. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989700
Funder
Australian Research Council
Funding Amount
$175,000.00
Summary
The Australian Policy Online Full-Text Research Repository and Thematic Gateways. By bringing together the research outputs of over 160 member centres and institutes, as well as selected material from government and other sources, Australian Policy Online (APO) makes a significant contribution to the national research effort across all National Research Priorities - environmental sustainability, promoting and maintaining good health, frontier technologies and safeguarding Australia - and to the ....The Australian Policy Online Full-Text Research Repository and Thematic Gateways. By bringing together the research outputs of over 160 member centres and institutes, as well as selected material from government and other sources, Australian Policy Online (APO) makes a significant contribution to the national research effort across all National Research Priorities - environmental sustainability, promoting and maintaining good health, frontier technologies and safeguarding Australia - and to the development of well-informed public policy. This project will increase the value of APO by deepening its coverage of preventative health, planning and the environment, and citizenship; broadening its collection of research material; and offering new resources for researchers.Read moreRead less
Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and p ....Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and private sector organisations in Australia and New Zealand, the project intends to identify the factors that influence good and bad responses across a range of institutions; provide a clearer basis for reform of policies, procedures and law; and set benchmarks for comparative research worldwide.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less