Communicating with older people across transition points of care. This project aims to examine how health professionals, older people and their family members communicate in managing medications as older people move through transition points of care. Communication problems often occur as older people move between and within settings, often leading to harmful medication incidents. The project expects to facilitate medication safety as older people move across different settings and to facilitate ....Communicating with older people across transition points of care. This project aims to examine how health professionals, older people and their family members communicate in managing medications as older people move through transition points of care. Communication problems often occur as older people move between and within settings, often leading to harmful medication incidents. The project expects to facilitate medication safety as older people move across different settings and to facilitate cultural shifts in health care communication and opportunities for consumer involvement.Read moreRead less
Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing ....Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing the need for revision surgery. Read moreRead less
Synthetic derivatives of capsaicin and gingerols as analgesics acting at the vanilloid receptor. This project aims to prepare alpha-hydroxyketones and gingerol derivatives acting at vanilloid (VR1) receptor with potential analgesic activity. These compounds will be tested for their ability to activate the VR1 receptor, desensitize the receptor and release neuropeptides associated with pain pathways. The development of these novel compounds will contribute towards understanding the mechanisms of ....Synthetic derivatives of capsaicin and gingerols as analgesics acting at the vanilloid receptor. This project aims to prepare alpha-hydroxyketones and gingerol derivatives acting at vanilloid (VR1) receptor with potential analgesic activity. These compounds will be tested for their ability to activate the VR1 receptor, desensitize the receptor and release neuropeptides associated with pain pathways. The development of these novel compounds will contribute towards understanding the mechanisms of VR1 receptor activation and provide information on how the VR1 receptor is regulated. We will determine and compare neurotoxicity of these compounds to capsaicin which is known to possess neurotoxic activity. The outcome of this project may result in effective agents for better pain management.
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Carbon Dioxide: Solvent, Carrier and Reagent, for novel polymer networks with controlled nano-architectures. The proposed environmentally friendly technology has broad applications for improving properties of various polymeric matrices used for biomedical applications. The process developed would value-add for manufacturing biomedical polymeric devices in Australia with licensing of existing fabrication methods as a best option. Moreover, the leading-edge polymer technology developed would mini ....Carbon Dioxide: Solvent, Carrier and Reagent, for novel polymer networks with controlled nano-architectures. The proposed environmentally friendly technology has broad applications for improving properties of various polymeric matrices used for biomedical applications. The process developed would value-add for manufacturing biomedical polymeric devices in Australia with licensing of existing fabrication methods as a best option. Moreover, the leading-edge polymer technology developed would minimise the organic solvent consumption and will attract business from international polymer and biotechnology companies for production of implant and drug delivery devices. The development of world-class research provides Australia with recognition as a world leader in the field and broadens the knowledge based of Australian scientist and engineers.Read moreRead less
Engineering of co-crystal drug molecules for pharmaceutical aerosols. This project will enable Australia to become a world leader in treatment of respiratory diseases. The Australian financial burden of respiratory diseases is currently estimated as $900m with significant impact on infrastructure (through regular clinical visits, hospitalisation and workforce loss). The global market for the treatment of COPD is currently $32 billion and is expected to increase significantly by 2010. The positio ....Engineering of co-crystal drug molecules for pharmaceutical aerosols. This project will enable Australia to become a world leader in treatment of respiratory diseases. The Australian financial burden of respiratory diseases is currently estimated as $900m with significant impact on infrastructure (through regular clinical visits, hospitalisation and workforce loss). The global market for the treatment of COPD is currently $32 billion and is expected to increase significantly by 2010. The positioning of an Australian research as a world leader in the development of new treatments will have significant national benefit, whilst the sector will benefit for scientific advancements that arise during this project.Read moreRead less
Dispersion of Pharmaceutical Powders as Aerosols for Inhalation. The detrimental environmental effects of chlorofluorocarbons (CFC) have led to an urgent need of a replacement for the existing CFC propellant driven medical inhalers. Generation of aerosols from dry powders has enormous potential as an alternative for delivery of drugs to the lung. The aims of the proposed research are to investigate specifically the powder surface properties and the orperating conditions on the dispersion of po ....Dispersion of Pharmaceutical Powders as Aerosols for Inhalation. The detrimental environmental effects of chlorofluorocarbons (CFC) have led to an urgent need of a replacement for the existing CFC propellant driven medical inhalers. Generation of aerosols from dry powders has enormous potential as an alternative for delivery of drugs to the lung. The aims of the proposed research are to investigate specifically the powder surface properties and the orperating conditions on the dispersion of powders as aerosols for inhalation. The knowledge gained will acclerate the design of better powder aerosols, thus benefiting patients suffering from respiratory and systemic diseases.Read moreRead less