Neuronal communication relies on the process of exocytosis by which neurons release a neurotransmitter. Exocytosis is critical for the simplest muscle movement to complex tasks such as learning and memory, and is altered in several neurodegenerative pathologies. We will investigate how the protein Munc18 controls exocytosis. This research will be important for understanding how neurons communicate in health and disease and will be relevant to other processes such as insulin release in diabetes.
The Functional Interplay Between Alpha Synuclein And Synaptophysin In Synaptic Vesicle Recycling
Funder
National Health and Medical Research Council
Funding Amount
$405,461.00
Summary
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting 7 million people worldwide. ?-synuclein is a protein in that brain that is likely to contribute to the death of brain cells in PD, but the normal role of the protein remains unknown. This study will investigate the function of ?-synuclein in maintaining normal healthy brain activity. In addition, this work will help us understand the processes that go awry in neurodegenerative disease states such as PD.
Investigations Into The Role Of Neurotransmitter Release From Astrocytes In The Hippocampus
Funder
National Health and Medical Research Council
Funding Amount
$233,057.00
Summary
While ten per cent of the brain consists of neurons, responsible for movement and thinking, the rest is made up of cells called glial cells. Scientists have always believed that astrocytes, a type of glial cell known for its distinctive star like shape, provide only mechanical and metabolic support for neurons, by maintaining the environment in the brain. This project will investigate how astrocytes actively regulate neuronal activity and may have important roles to play in learning and memory.