Bimolecular chemistry at very low temperatures. Many chemical reactions involve short-lived and highly reactive intermediates that cannot be observed under ordinary reaction conditions. Hence, much of this chemistry is shrouded in mystery. This project aims to develop the ability to observe and monitor such reactions directly using a combination of spectroscopies at very low temperatures, where the molecules are more stable and reactions slower. These studies will give quantitative information ....Bimolecular chemistry at very low temperatures. Many chemical reactions involve short-lived and highly reactive intermediates that cannot be observed under ordinary reaction conditions. Hence, much of this chemistry is shrouded in mystery. This project aims to develop the ability to observe and monitor such reactions directly using a combination of spectroscopies at very low temperatures, where the molecules are more stable and reactions slower. These studies will give quantitative information on the nature of the reactive intermediates themselves, the nature of the products formed, and the reaction dynamics, and they are of fundamental importance for an understanding of chemical reactivity generally. The methodology developed will be applicable to the investigation of a wide range of processes.Read moreRead less
New mechanisms and methods in carbene and nitrene chemistry. Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will ....New mechanisms and methods in carbene and nitrene chemistry. Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will contribute fundamental knowledge of the nature and reactions of these species by using direct spectroscopic observation. We are proposing the occurrence of novel types of reactions and the formation of several new reactive intermediates as well as a technique for the stabilization of reactive intermediates by incorporation into macrocyclic frameworks.Read moreRead less
Educating for healthy citizens: the health work of teachers in Australian schools. Teachers promote students health every day in many ways, such as performing periodic health checks, teaching health education lessons, or leading pastoral care. This project looks at what, and how much, health work teachers undertake and how prepared they are to do this work.
A cluster randomised controlled trial of a school-based physical activity intervention in at-risk communities. This project will test the effect of a professional development program targeting physical education teachers, designed to increase students' opportunities to do physical activity during physical education lessons. It will focus on how to enhance their motivation to not only be physically active during physical education lessons, but also outside school hours.
The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magneto ....The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. Based on our preliminary investigations, which suggest that the activity of bacterial MS channels may be affected by magnetic fields, we propose to study effects of magnetic fields on MS ion channels in Gram-negative bacteria Escherichia coli and Magnetospirillum magnetotacticum. The project promises also to contribute towards better understanding of adverse effects of electromagnetic radiation on human health and towards understanding the mechanisms behind remote magnetic-nanoparticle mediated activation of MS ion channels.Read moreRead less
Reactive intermediates and microwave-assisted organic reactions. The use of our chemistry to help develop new, safer, better drugs against schizophrenia is a strong driving force for this research. This relates to the National Research Priority of promoting and maintaining good health, ageing well and productively, and preventative healthcare. Microwave-assisted chemical synthesis will undoubtedly become a very important methodology in the pharmaceutical industry, and our work will help develop ....Reactive intermediates and microwave-assisted organic reactions. The use of our chemistry to help develop new, safer, better drugs against schizophrenia is a strong driving force for this research. This relates to the National Research Priority of promoting and maintaining good health, ageing well and productively, and preventative healthcare. Microwave-assisted chemical synthesis will undoubtedly become a very important methodology in the pharmaceutical industry, and our work will help developing such know-how in Australia and thereby contribute to the Australian economic fabric. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882778
Funder
Australian Research Council
Funding Amount
$201,224.00
Summary
Water vapour radiometers for millimetre-wave phase correction for the Australia Telescope. Australia has a tradition of excellence in astronomy. Inspired by wonder about the cosmos, it stimulates public interest in science, so leading to the training of highly skilled graduates. In turn, this drives the development of technologies needed to pursue the science. The nation has invested in the technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. This equipm ....Water vapour radiometers for millimetre-wave phase correction for the Australia Telescope. Australia has a tradition of excellence in astronomy. Inspired by wonder about the cosmos, it stimulates public interest in science, so leading to the training of highly skilled graduates. In turn, this drives the development of technologies needed to pursue the science. The nation has invested in the technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. This equipment will capitalise on this investment, extending the capabilities of the Australia Telescope to maintain it as a front line instrument, attracting the best scientists here to use it. This will help nurture a vigorous radio-science community, one able to actively participate in the billion-dollar investment being made internationally in the field.Read moreRead less
The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These f ....The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These findings will inform the current debate about the appropriate models of teacher education and the balance of emphasis on content knowledge and pedagogical knowledge. Secondly, given a number of attempts to attract mid career professionals with high qualifications to teaching, the study will provide evidence on how these people transition to their new careers and what support is needed.Read moreRead less
Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are droppi ....Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are dropping behind in international competitiveness in reading and literacy achievement. The study concentrates on early reading development and to inform on teacher education and classroom teaching practices. Read moreRead less
Researching Collective Argumentation in Mathematics and Science Classrooms. The project will provide evidence-based pedagogical strategies for the reform of classroom teaching and learning in the crucial areas of mathematics and science. We will develop a form of pedagogy (Collective Argumentation) that enables students to be confident in deploying mathematical and scientific knowledge and skills in relation to the economic and social choices that they make in everyday contexts. Collective Argum ....Researching Collective Argumentation in Mathematics and Science Classrooms. The project will provide evidence-based pedagogical strategies for the reform of classroom teaching and learning in the crucial areas of mathematics and science. We will develop a form of pedagogy (Collective Argumentation) that enables students to be confident in deploying mathematical and scientific knowledge and skills in relation to the economic and social choices that they make in everyday contexts. Collective Argumentation can induct students into 'habits of mind and social practices' necessary for building an innovative learning community. This project will enable us to extend this innovative approach and to further develop its effectiveness.Read moreRead less