Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpi ....Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.Read moreRead less
Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecule ....Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecules which are present in interstellar ice and dust clouds. The structures and chemistry of such molecules are of importance in understanding the origins of life on this planet.Read moreRead less
The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend ....The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend the applicability of analytical negative-ion mass spectrometry, (ii) form neutral molecules and related species which are found in stellar dust clouds and investigate their chemistry, and (iii) train graduates in ion chemistry to the highest international standards.Read moreRead less
Cumulenes and Heterocumulenes - Stellar Molecules and New Materials. This project involves the formation and characterisation of transient neutrals (formed in the mass spectrometer by neutralisation of charged precursor ions) which are either found in stellar dust clouds, or related molecules which may be either potential stellar molecules or have importance in the development of new materials. This work may lead to a better understanding of how biomolecules are formed in interstellar environs. ....Cumulenes and Heterocumulenes - Stellar Molecules and New Materials. This project involves the formation and characterisation of transient neutrals (formed in the mass spectrometer by neutralisation of charged precursor ions) which are either found in stellar dust clouds, or related molecules which may be either potential stellar molecules or have importance in the development of new materials. This work may lead to a better understanding of how biomolecules are formed in interstellar environs. The Adelaide and Berlin groups are internationally known, already with ongoing collaboration. This application seeks to extend the scope of this world-class research, and to train the premier graduate students in astrochemistry.Read moreRead less
Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a s ....Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a space-time lattice. Simulating fermions on a lattice has proved very challenging. This project will explore novel and innovative improved fermion algorithms for the general problem of gauge theories on the lattice.Read moreRead less
Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous syst ....Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system.
(ii) to study the possibility of the formation of biological molecules of life in interstellar regions
(iii) to train graduate students to international standards in the chemistry of proteomics.Read moreRead less
Children of the new millennium: Using information and communication technologies for playing and learning in the information age. This research explores the development of young children's expertise with information and communication technologies from the preschool to the second year of school. It examines where young children in diverse socioeconomic areas use information and communication technologies, how many forms of it they use and to what extent technology relates to other forms of play ....Children of the new millennium: Using information and communication technologies for playing and learning in the information age. This research explores the development of young children's expertise with information and communication technologies from the preschool to the second year of school. It examines where young children in diverse socioeconomic areas use information and communication technologies, how many forms of it they use and to what extent technology relates to other forms of play and learning in literacy and numeracy. An assessment tool will be developed to explore how children's knowledge, understanding and use of technology changes over time. The research will inform policy and curriculum directions in the early years of education.Read moreRead less
Building the capabilities of school communities to improve their wellbeing. Wellbeing remains an issue for all education systems and for the nation. One indicator of this is that, on average, one in six Australian students experience affronts to their wellbeing through bullying or harassment at least once a week. Teacher wellbeing is also an issue of national importance as education systems face issues of teacher retention. This project will provide a model that can be used by other schools and ....Building the capabilities of school communities to improve their wellbeing. Wellbeing remains an issue for all education systems and for the nation. One indicator of this is that, on average, one in six Australian students experience affronts to their wellbeing through bullying or harassment at least once a week. Teacher wellbeing is also an issue of national importance as education systems face issues of teacher retention. This project will provide a model that can be used by other schools and educational systems for development of interventions that address wellbeing issues of social competence, learning and leadership for key groups in school communities. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100510
Funder
Australian Research Council
Funding Amount
$350,977.00
Summary
How first-in-family males transition to Australian university life. This project aims to study how gender, ethnicity and social class affect Australian males from low socio-economic backgrounds as they transition to university. Despite an emphasis on widening participation in the Australian university sector, the path to university is still precarious, particularly for first-in-family students. Males from low socio-economic backgrounds remain severely underrepresented in higher education, and ho ....How first-in-family males transition to Australian university life. This project aims to study how gender, ethnicity and social class affect Australian males from low socio-economic backgrounds as they transition to university. Despite an emphasis on widening participation in the Australian university sector, the path to university is still precarious, particularly for first-in-family students. Males from low socio-economic backgrounds remain severely underrepresented in higher education, and how these students experience university life is unclear. The project will use qualitative research to better understand the experiences of first-in-family males entering universities in different locales/institutions across Australia. Expected outcomes include improved targeted support systems to enable their success.Read moreRead less
Cyberkids and cyberworlds: new literacies, identities and communities in formation. Little is known of the online cyberworlds of young Australians. Yet they are the highest users of Information and Communications Technologies (ICTs). This project theorises that these cyberworlds are sites for the development of new forms of literacy, identity and community. This study will achieve a new perspective by utilising a multi-disciplinary approach to produce case studies that examine new literacies an ....Cyberkids and cyberworlds: new literacies, identities and communities in formation. Little is known of the online cyberworlds of young Australians. Yet they are the highest users of Information and Communications Technologies (ICTs). This project theorises that these cyberworlds are sites for the development of new forms of literacy, identity and community. This study will achieve a new perspective by utilising a multi-disciplinary approach to produce case studies that examine new literacies and communities generated online and their consequences for literacy and ICT education practice. Such information is vital in Australia and internationally if education is to produce the highly technologically literate citizens on whom future economic prosperity depends.Read moreRead less