Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Expecting the unexpected: how people prioritise predictability. This project aims to investigate how people represent and use information about unpredictability in their environment. Seeing too much predictability is problematic, but seeing too little can also be a problem, for example inappropriate "learned helplessness" can occur, whereby people feel disempowered because the world is seen as random. Recent findings demonstrated a bias in fundamental learning that may maintain these inappropria ....Expecting the unexpected: how people prioritise predictability. This project aims to investigate how people represent and use information about unpredictability in their environment. Seeing too much predictability is problematic, but seeing too little can also be a problem, for example inappropriate "learned helplessness" can occur, whereby people feel disempowered because the world is seen as random. Recent findings demonstrated a bias in fundamental learning that may maintain these inappropriate beliefs about unpredictability. This bias is not anticipated by formal theories of learning. The project will investigate how this bias is brought about by first formalising a novel theory of fundamental learning and then systematically testing its assumptions.Read moreRead less
The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early ....The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early in life determines sensitivity to pain in adult life. In doing so, this research offers a new theoretical explanation for the ontogeny of pain and may begin to account for the many forms of chronic pain that are currently not only unexplainable from current pain theory, but difficult to manage clinically.Read moreRead less
Killing which averts suffering: the role of norms and empathy. Abattoir workers and butchers kill animals to prepare food, farmers to cull stock, and veterinarians to alleviate suffering. Soldiers kill other humans in war, police or security guards to protect the public, and doctors to enact legal euthanasia. Research shows that these tasks can be confronting, and even traumatic. This project aims to test the processes through which people learn socially supported palliative killing to avert suf ....Killing which averts suffering: the role of norms and empathy. Abattoir workers and butchers kill animals to prepare food, farmers to cull stock, and veterinarians to alleviate suffering. Soldiers kill other humans in war, police or security guards to protect the public, and doctors to enact legal euthanasia. Research shows that these tasks can be confronting, and even traumatic. This project aims to test the processes through which people learn socially supported palliative killing to avert suffering and their neural underpinnings, with a focus on norms and empathic distress. It will focus on two core samples: veterinarians, who must euthanize animals, and health practitioners in Victoria, where legal changes will introduce ‘voluntary assisted dying’ in mid-2019. It will investigate how practitioners learn palliative killing, and what the impact is on psychological variables such as empathy and identity. It will generate new understandings of social influence around life and death decisions, provide an evidence basis to inform policy makers, and help institutions and practitioners seeking to manage distress and respond to fast-moving, controversial policy changes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100667
Funder
Australian Research Council
Funding Amount
$328,000.00
Summary
How “known unknowns” become known: How do people encode unpredictability? As Donald Rumsfeld noted, there are 'known unknowns’. That is to say, people are seemingly capable of learning that some things cannot be reliably predicted. This learning underpins decisions from the trivial (whether to pack a jacket) to the life-defining (whom to marry). An aberrant form of this learning may also underlie mental health disorders. Yet the mechanisms of such learning have been largely overlooked by cogniti ....How “known unknowns” become known: How do people encode unpredictability? As Donald Rumsfeld noted, there are 'known unknowns’. That is to say, people are seemingly capable of learning that some things cannot be reliably predicted. This learning underpins decisions from the trivial (whether to pack a jacket) to the life-defining (whom to marry). An aberrant form of this learning may also underlie mental health disorders. Yet the mechanisms of such learning have been largely overlooked by cognitive scientists and thus are poorly understood. The project, which is based on significant pilot data, aims to examine when and how people learn about unpredictability, and what the cognitive, memorial, neural and affective consequences of this learning are.Read moreRead less
ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishi ....ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishing features of the Centre will be the international, integrative, and multidisciplinary approach towards addressing major questions in plant biology, its strategy to leverage ARC funding, and its linkages with potential national and international end-users of the fundamental scientific discoveries.Read moreRead less
Diatom lipids to reveal sea-ice history in remote Antarctic regions. This project aims to understand seasonal Antarctic sea-ice extent using molecular, geochemical, elemental and genomic characteristics of specific marine phytoplankton (diatoms). Little is known of the seasonal sea-ice variation and the position of the summer sea-ice extent a million years before satellite records, but this information is critical to determining air-sea gas exchange and ecosystem food web regulation. This projec ....Diatom lipids to reveal sea-ice history in remote Antarctic regions. This project aims to understand seasonal Antarctic sea-ice extent using molecular, geochemical, elemental and genomic characteristics of specific marine phytoplankton (diatoms). Little is known of the seasonal sea-ice variation and the position of the summer sea-ice extent a million years before satellite records, but this information is critical to determining air-sea gas exchange and ecosystem food web regulation. This project will unite geochemical and biological approaches to provide the data to improve past Antarctic ecosystem and climate models where sea-ice data is missing. Studying diatom biomarkers in deep sea cores from Australia’s Southern Ocean will redefine knowledge of Antarctic climate and provide data necessary to improve global ecosystem and climate models.Read moreRead less
Sleepy and sitting: a dual curse for the modern workforce? This project aims to generate new knowledge about the impact of inadequate sleep and prolonged sitting on health markers and performance. Many workers, particularly those working outside standard hours, experience both prolonged sitting and inadequate sleep. Expected outcomes of this project include critical evidence to address the dual burden experienced by a large population of workers who are both sleepy and sitting. This should provi ....Sleepy and sitting: a dual curse for the modern workforce? This project aims to generate new knowledge about the impact of inadequate sleep and prolonged sitting on health markers and performance. Many workers, particularly those working outside standard hours, experience both prolonged sitting and inadequate sleep. Expected outcomes of this project include critical evidence to address the dual burden experienced by a large population of workers who are both sleepy and sitting. This should provide significant benefits for the many working Australians whose health and safety is compromised due to their exposure to inadequate sleep and prolonged sitting. It will also contribute to the evidence-base for workplace policies and public health guidelines.Read moreRead less