A developmental and neural analysis of learned and unlearned fear. This project aims to increase our understanding of the emotion of fear from both a developmental and a neural perspective. Anxiety disorders, which are characterised by the inability to appropriately regulate fear, are among the most prevelant psychological disturbances in industrialised countries. The present project involves a neurobiological analysis of fear in the developing rat, and will (i) test the dominant theoretical mod ....A developmental and neural analysis of learned and unlearned fear. This project aims to increase our understanding of the emotion of fear from both a developmental and a neural perspective. Anxiety disorders, which are characterised by the inability to appropriately regulate fear, are among the most prevelant psychological disturbances in industrialised countries. The present project involves a neurobiological analysis of fear in the developing rat, and will (i) test the dominant theoretical models of learned fear, (ii) compare the development of learned and unlearned fear, and (iii) provide a novel approach for studying whether learned behavioural responses are appropriate to the age of training or the age of testing.Read moreRead less
When is extinction not extinction? Disorders of fear and anxiety are widespread and impose significant burdens on individual sufferers and their families. This projects studies new ways of augmenting loss of fear and will identify the important behavioural mechanisms as well as critical brain pathways for this fear loss.
Epigenetic effects of environmental thyroid disruption. Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling o ....Epigenetic effects of environmental thyroid disruption. Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling of experimental data will help to predict how animals respond to anthropogenic impacts, and to acquire the tools necessary to maintain ecosystem function and services. The project will therefore have environmental benefits, as well as social benefits stemming from international collaborations and training.Read moreRead less
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. T ....Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. The available tests provide information relevant to the later-stage of clinical depression only. In this regard, non-invasive and objective markers are urgently required to limit the burden of depression. In Australia, $3.3 billion in productivity and 12 million working days are lost each year as a result of depression.Read moreRead less
The causes of intrusive memories. Intrusive memories are pivotal to many psychological disorders. This project will extend current models of intrusive memories by integrating biological, cognitive, and neural measures to specify the causes of these memories.
Extinction of conditioned responding: Learning from the evidence of absence. When animals or people learn that a cue, or their own action, is followed by something important, they respond in anticipation of the outcome or to control it. This project investigates how these learned responses can be reduced (“extinguished”) when the conditions that established them change. It will help solve 2 outstanding theoretical and practical problems: what makes some learned behaviours resistant to extinction ....Extinction of conditioned responding: Learning from the evidence of absence. When animals or people learn that a cue, or their own action, is followed by something important, they respond in anticipation of the outcome or to control it. This project investigates how these learned responses can be reduced (“extinguished”) when the conditions that established them change. It will help solve 2 outstanding theoretical and practical problems: what makes some learned behaviours resistant to extinction or prone to relapse after being extinguished? The project will identify the factors that are most directly responsible for resistance and relapse. This could pave the way to finding solutions for the major problems that bedevil therapies designed to treat human behavioural disorders, such as addictions, gambling, and anxietyRead moreRead less
Extinction and response inhibition. Humans and other animals readily learn to perform an action if it is “reinforced” by a reward and will extinguish the action if it stops being reinforced. Popular models of learning describe extinction as the automatic outcome of a prediction-error correction process that gradually weakens, and eventually eliminates, the response-reward association. But there is much evidence that conditioned responses are not eliminated and can be quickly restored. Other evid ....Extinction and response inhibition. Humans and other animals readily learn to perform an action if it is “reinforced” by a reward and will extinguish the action if it stops being reinforced. Popular models of learning describe extinction as the automatic outcome of a prediction-error correction process that gradually weakens, and eventually eliminates, the response-reward association. But there is much evidence that conditioned responses are not eliminated and can be quickly restored. Other evidence suggests that extinction might involve more specific inhibitory processes that suppress the response without eliminating the original learning. The current project investigates the role of response inhibition in the extinction of learned responses in humans.Read moreRead less
The neural substrates of a false fear memory in rats. This project aims to use laboratory rodents to study false memory of an aversive experience (false fear memory). Memory is not always a faithful record of an experience. Particularly under emotional circumstances, events can be remembered in ways they never occurred. This project studies how a false fear memory forms, and the neural substrates of this memory in the amygdala and hippocampus. The findings should advance knowledge about how the ....The neural substrates of a false fear memory in rats. This project aims to use laboratory rodents to study false memory of an aversive experience (false fear memory). Memory is not always a faithful record of an experience. Particularly under emotional circumstances, events can be remembered in ways they never occurred. This project studies how a false fear memory forms, and the neural substrates of this memory in the amygdala and hippocampus. The findings should advance knowledge about how the brain represents events, how retrieved event representations associate with aspects of present events, and how learning about retrieved-but-absent events blurs the line between fantasy and reality.Read moreRead less
Existing knowledge determines how new experiences are encoded in the brain. The aim of this project is to identify how existing knowledge shapes the way that new fear memories are encoded and stored in the brain. It seeks to achieve this aim through the use of an animal model, Pavlovian fear conditioning in rats. It is significant in providing the first systematic assessment of fear memories that form when dangerous experiences are consistent versus inconsistent with existing knowledge. The expe ....Existing knowledge determines how new experiences are encoded in the brain. The aim of this project is to identify how existing knowledge shapes the way that new fear memories are encoded and stored in the brain. It seeks to achieve this aim through the use of an animal model, Pavlovian fear conditioning in rats. It is significant in providing the first systematic assessment of fear memories that form when dangerous experiences are consistent versus inconsistent with existing knowledge. The expected outcomes include new information regarding the links between existing knowledge, fear memories and their neural substrates. This information is needed for the development of a comprehensive theory that explains how the conditions under which fear memories form determines their content and wiring in the brain.Read moreRead less