Neural and cognitive studies of reward sensitivity and its influence on addiction-related behaviour. The proposed research aims to contribute to current scientific thinking on the influence of reward sensitivity on cognitive performance. Cognitive neuroscience research on this relationship is of major scientific interest because heightened reward sensitivity is a significant predictor of risk for a number of Australia's major social and economic problems. The findings of this project will contri ....Neural and cognitive studies of reward sensitivity and its influence on addiction-related behaviour. The proposed research aims to contribute to current scientific thinking on the influence of reward sensitivity on cognitive performance. Cognitive neuroscience research on this relationship is of major scientific interest because heightened reward sensitivity is a significant predictor of risk for a number of Australia's major social and economic problems. The findings of this project will contribute to the debate about how to manage such problems.Read moreRead less
Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach. The proposed research aims to contribute to current scientific thinking on how the processing of errors influences self-monitoring and cognitive performance. The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions, where it is a reliable predictor of a poor prognostic outcome. This project ....Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach. The proposed research aims to contribute to current scientific thinking on how the processing of errors influences self-monitoring and cognitive performance. The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions, where it is a reliable predictor of a poor prognostic outcome. This project aims to clarify understanding of the cognitive and neural processes underlying self-monitoring, as an important first step to improving rehabilitation and management methods for age-related impairments such as Alzheimer's disease, and prominent mental health conditions such as schizophrenia.Read moreRead less
Improving cognitive function in the elderly. The ageing population has been identified as one of the major issues facing contemporary Australian society. For Australia, human ageing has significant societal, economic and, importantly, personal/human costs. The economic costs associated with ageing reflect decreased productivity as well as a higher incidence of a variety of illnesses including cardiovascular and respiratory disease and, importantly, neurological conditions such as Parkinson's dis ....Improving cognitive function in the elderly. The ageing population has been identified as one of the major issues facing contemporary Australian society. For Australia, human ageing has significant societal, economic and, importantly, personal/human costs. The economic costs associated with ageing reflect decreased productivity as well as a higher incidence of a variety of illnesses including cardiovascular and respiratory disease and, importantly, neurological conditions such as Parkinson's disease (PD) and Alzheimer's disease (AD). We will complete two large scale studies examining the efficacy of twelve months administration of two pharmacologically active supplements in reducing the cognitive effects of aging in elderly participants.
Read moreRead less
Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated ....Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated to provide a means for understanding how management interventions can alter energy flows in biological systems, bringing benefits across the areas of climate change adaptation, conservation science, agriculture and aquaculture, and fisheries management.Read moreRead less
The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The curr ....The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The current project is directly relevant to the genetics of mental disorders, such as attention deficit hyperactivity (ADHD), that place a large burden, both financially and emotionally, on our society. Understanding the genes and biological pathways that increase risk for mental disorders will ultimately lead to improved treatments for these conditions.Read moreRead less
A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by sele ....A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by selective breeding or genetic manipulation, yielding potential benefits for aquaculture (enhanced growth) or re-introduction (enhanced reproduction).Read moreRead less
Common synaptic inputs to human upper airway muscles. Changes in the activity of upper airway muscles at sleep onset contribute to the development of Obstructive Sleep Apnoea. The aim of this project is to investigate how the brain controls upper airway muscles during wakefulness and sleep and to identify the pathological processes that lead to the development of Obstructive Sleep Apnoea.
Mechanisms and contexts driving impulsivity. The project aims to develop insights into the cognitive mechanisms of impulsivity (the tendency to act without planning) and the impact of context on impulsive behaviours. The project aims to test a novel framework that views impulsivity as the product of three cognitive mechanisms: i) attention, ii) information gathering and iii) monitoring, which oscillate in response to day-to-day contexts. Knowledge of the mechanisms and contexts driving impulsivi ....Mechanisms and contexts driving impulsivity. The project aims to develop insights into the cognitive mechanisms of impulsivity (the tendency to act without planning) and the impact of context on impulsive behaviours. The project aims to test a novel framework that views impulsivity as the product of three cognitive mechanisms: i) attention, ii) information gathering and iii) monitoring, which oscillate in response to day-to-day contexts. Knowledge of the mechanisms and contexts driving impulsivity will enable prediction of the emergence of impulsive behaviours in real-life and real-time. The expected outcomes can enable better moderation of impulsivity and improve health.Read moreRead less
How exercise modulates neural plasticity and memory consolidation. This project aims to examine how genetic variation in humans affects the capacity of exercise to augment neural plasticity and learning. This project expects to generate new knowledge through an innovative approach combining genetics, exercise physiology, and cognitive neuroscience. It is expected the outcomes will have implications for human learning, workplace productivity, and training protocols for rehabilitation and sport. E ....How exercise modulates neural plasticity and memory consolidation. This project aims to examine how genetic variation in humans affects the capacity of exercise to augment neural plasticity and learning. This project expects to generate new knowledge through an innovative approach combining genetics, exercise physiology, and cognitive neuroscience. It is expected the outcomes will have implications for human learning, workplace productivity, and training protocols for rehabilitation and sport. Exercise is a cheap way to enhance neural plasticity and improve behavioural performance, which is of benefit to employers, our economy, and individuals. A possible future application of this research could be the personalised prescription of exercise for brain health based on an individual’s genetics.Read moreRead less
How inhibition shapes human brain oscillations and working memory capacity. This project aims to investigate the link between inhibitory mechanisms, gamma oscillations and working memory in humans. Retaining information in short-term ‘working’ memory is crucial for cognition, influencing our personality and intelligence. However, the brain mechanisms underlying this process are unclear. Evidence from animal/computational research indicates that brain oscillations in high frequency ‘gamma’ bands, ....How inhibition shapes human brain oscillations and working memory capacity. This project aims to investigate the link between inhibitory mechanisms, gamma oscillations and working memory in humans. Retaining information in short-term ‘working’ memory is crucial for cognition, influencing our personality and intelligence. However, the brain mechanisms underlying this process are unclear. Evidence from animal/computational research indicates that brain oscillations in high frequency ‘gamma’ bands, which depend on neural inhibition, are critical for working memory. Mapping a path from molecules to cognition will detail how neural mechanisms shape human behavioural performance and guide efforts to enhance memory and cognitive function.Read moreRead less