CogChip: development of a targeted genotyping chip for executive function. This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The pr ....CogChip: development of a targeted genotyping chip for executive function. This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The project proposes to leverage this knowledge to develop a customised genotyping chip, which may find application for prediction of individual differences in executive ability across multiple settings including education and industry. Expected outcomes for the project will include breakthrough insights into the biology of cognition, and a genetic read-out of individual differences in executive ability, which could have broad application including the potential to facilitate the targeting of cognitive, educational or workplace training for those most at risk of adverse outcomes.Read moreRead less
Next generation smart lighting to improve sleep and alertness. Light has a powerful influence on our sleep and alertness. The manipulation of the amount of blue in a light source and the visual brightness of a light source are key factors, but there has been no systematic study that can guide manufacturers in the design of the ideal light source for promoting either sleep or alertness. This study will systematically examine the impact of the amount of blue light in a light source and the visual ....Next generation smart lighting to improve sleep and alertness. Light has a powerful influence on our sleep and alertness. The manipulation of the amount of blue in a light source and the visual brightness of a light source are key factors, but there has been no systematic study that can guide manufacturers in the design of the ideal light source for promoting either sleep or alertness. This study will systematically examine the impact of the amount of blue light in a light source and the visual brightness, creating a wide range of combinations that can be used to model the optimal light specifications for sleep and alertness, while maintaining visual acuity and colour discrimination. This will be the evidence base needed by the lighting industry to create the next generation of smart lighting.Read moreRead less
Cerebral plasticity or early vulnerability? Identifying critical periods for childhood development and recovery. The primary aim of the study is to identify critical time periods during brain development when an insult will have more deleterious consequences for recovery and outcome. The study will also examine the impact of other potential influences to recovery following early brain disease, and determine whether their impact varies across development. Finally, the study will investigate wh ....Cerebral plasticity or early vulnerability? Identifying critical periods for childhood development and recovery. The primary aim of the study is to identify critical time periods during brain development when an insult will have more deleterious consequences for recovery and outcome. The study will also examine the impact of other potential influences to recovery following early brain disease, and determine whether their impact varies across development. Finally, the study will investigate whether specific cognitive and behavioural domains are differentially effected, depending on their maturity at the time of brain insult. Findings from this study will inform the development of conceptual models of early brain insult and recovery of function, and contribute to clinical practice.Read moreRead less
Environmental impact on neuroendocrine and neurobiological mechanisms: treatment strategies and mimetics for maintaining good health. The current societal climate of industrialized countries such as Australia has shifted considerable over recent decades and is now one which is highly conducive to overfeeding and reduced physical activity. As a result, the incidence of obesity has risen markedly along with an associated increase in obesity-related chronic diseases such as cardiovascular disease, ....Environmental impact on neuroendocrine and neurobiological mechanisms: treatment strategies and mimetics for maintaining good health. The current societal climate of industrialized countries such as Australia has shifted considerable over recent decades and is now one which is highly conducive to overfeeding and reduced physical activity. As a result, the incidence of obesity has risen markedly along with an associated increase in obesity-related chronic diseases such as cardiovascular disease, stroke, obstructive pulmonary disease, type II diabetes, and many types of cancers. Less is known about the psychological and behavioural sequelae of this overfeeding. Calorie restriction mimetics may not only act as a preventative intervention to help reduce the incidence and severity of these major health problems, but also impact on social behaviour.Read moreRead less
Acting with the future in mind. This project seeks to establish whether it is possible to enhance the prospective memory function of healthy older adults. Prospective memory refers to memory for future intentions and is used in many daily activities that are critical for the maintenance of independence in late adulthood, such as remembering to take medication and turn off appliances. The project intends to conduct the first controlled study to use prospective memory activities to directly train ....Acting with the future in mind. This project seeks to establish whether it is possible to enhance the prospective memory function of healthy older adults. Prospective memory refers to memory for future intentions and is used in many daily activities that are critical for the maintenance of independence in late adulthood, such as remembering to take medication and turn off appliances. The project intends to conduct the first controlled study to use prospective memory activities to directly train prospective memory using both major cognitive training approaches: process training (restorative) and strategy training (compensatory). The results should have implications for clarifying how prospective memory function can be optimised in late adulthood, which will be important for healthy ageing.Read moreRead less
Mapping cognitive impulsivity through online testing. The project aims to develop a new model of cognitive impulsivity and produce an online tool to measure it. Impulsivity is defined as the skill/s that exert control over impulsive behaviours. It is a trait of human cognition that affects health and productivity and that varies normatively across the healthy population. However, coherent models of cognitive impulsivity and comprehensive measures of the construct are lacking. The project aims to ....Mapping cognitive impulsivity through online testing. The project aims to develop a new model of cognitive impulsivity and produce an online tool to measure it. Impulsivity is defined as the skill/s that exert control over impulsive behaviours. It is a trait of human cognition that affects health and productivity and that varies normatively across the healthy population. However, coherent models of cognitive impulsivity and comprehensive measures of the construct are lacking. The project aims to unravel and measure the cognitive skills that can produce (or avoid) impulsive behaviour.Read moreRead less
Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to de ....Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to develop strategies for prevention, surveillance and remediation of adverse outcomes in early childhood, thus supporting the Government's National Agenda for Early Childhood initiative. As a consequence educational assistance can be targeted for those children likely to experience difficulties. Read moreRead less
The neural effects of torture. Torture affects millions of people and causes much long-term psychological harm. This project aims to identify the effects that torture has on the brain by studying torture survivors in the context of a range of brain imaging technologies that will lead to development of a model of the neural effects of torture to guide better treatments.
Biomarkers and objective assessment of cognitive and brain effects of fish oil dietary supplementation. There are potential widespread community benefits from knowing whether consuming fish oils will improve cognitive function. This is mainfest in children and even more so in those suffering attention deficits at a time when inattention and hyperacitvity is likely to permanently lower their overall career prospects.
Predicting the evolution of psychosocial and cognitive difficulties in epilepsy: A preventive approach. Chronic epilepsy is associated with significant psychosocial and cognitive difficulties. Research has neglected to examine how these problems evolve from the time of a first seizure, limiting our ability to predict ?at risk? patients and apply evidence-based preventive strategies. We will follow a cohort of 90 first seizure patients over two years in a prospective longitudinal investigation, m ....Predicting the evolution of psychosocial and cognitive difficulties in epilepsy: A preventive approach. Chronic epilepsy is associated with significant psychosocial and cognitive difficulties. Research has neglected to examine how these problems evolve from the time of a first seizure, limiting our ability to predict ?at risk? patients and apply evidence-based preventive strategies. We will follow a cohort of 90 first seizure patients over two years in a prospective longitudinal investigation, mapping psychosocial and cognitive change. This study entails a multidisciplinary collaboration with industry, applying innovative psychosocial and cognitive measures that will ultimately improve the detection of adverse pharmaceutical side-effects. The project is an international first, and will provide an important foundation for implementing preventive healthcare.Read moreRead less