Epigenetic effects of environmental thyroid disruption. Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling o ....Epigenetic effects of environmental thyroid disruption. Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling of experimental data will help to predict how animals respond to anthropogenic impacts, and to acquire the tools necessary to maintain ecosystem function and services. The project will therefore have environmental benefits, as well as social benefits stemming from international collaborations and training.Read moreRead less
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Extinction of conditioned responding: Learning from the evidence of absence. When animals or people learn that a cue, or their own action, is followed by something important, they respond in anticipation of the outcome or to control it. This project investigates how these learned responses can be reduced (“extinguished”) when the conditions that established them change. It will help solve 2 outstanding theoretical and practical problems: what makes some learned behaviours resistant to extinction ....Extinction of conditioned responding: Learning from the evidence of absence. When animals or people learn that a cue, or their own action, is followed by something important, they respond in anticipation of the outcome or to control it. This project investigates how these learned responses can be reduced (“extinguished”) when the conditions that established them change. It will help solve 2 outstanding theoretical and practical problems: what makes some learned behaviours resistant to extinction or prone to relapse after being extinguished? The project will identify the factors that are most directly responsible for resistance and relapse. This could pave the way to finding solutions for the major problems that bedevil therapies designed to treat human behavioural disorders, such as addictions, gambling, and anxietyRead moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100856
Funder
Australian Research Council
Funding Amount
$398,671.00
Summary
Oxytocin enhances the processing of environmental cues. Oxytocin is a powerful neuromodulator for social and emotional processing. Despite extensive research demonstrating pro-social and anxiolytic effects of oxytocin, the psychological processes that produce its effects are unknown. My hypothesis is that oxytocin enhances attention to cues that signal emotionally significant outcomes. This project will systematically assess the neural and psychological mechanisms underlying OT's effects using a ....Oxytocin enhances the processing of environmental cues. Oxytocin is a powerful neuromodulator for social and emotional processing. Despite extensive research demonstrating pro-social and anxiolytic effects of oxytocin, the psychological processes that produce its effects are unknown. My hypothesis is that oxytocin enhances attention to cues that signal emotionally significant outcomes. This project will systematically assess the neural and psychological mechanisms underlying OT's effects using an associative learning framework through an innovative combination of Pavlovian conditioning, behavioural pharmacology, chemogenetic and transgenic methods. This is the first project to use an associative learning framework to understand the psychological processes that produce oxytocin’s effects. Read moreRead less
The processing of fear in the medial temporal lobe. The aim of this project is to identify how fear affects information processing in the medial temporal lobe (MTL). It is significant in providing the first systematic assessment of how fear alters processing of different types of information in the MTL, including the innocuous; and how fear affects processing of memories in MTL networks, including their integration. The expected outcomes are basic knowledge regarding these effects of fear, and a ....The processing of fear in the medial temporal lobe. The aim of this project is to identify how fear affects information processing in the medial temporal lobe (MTL). It is significant in providing the first systematic assessment of how fear alters processing of different types of information in the MTL, including the innocuous; and how fear affects processing of memories in MTL networks, including their integration. The expected outcomes are basic knowledge regarding these effects of fear, and a theory of MTL function in which they are explained. The benefit of this knowledge is a better understanding of how information is processed in a normal brain, and therefore, disturbances to information processing in fear-related disorders (e.g., over-generalization of fear in post-traumatic stress).Read moreRead less
Extinction and response inhibition. Humans and other animals readily learn to perform an action if it is “reinforced” by a reward and will extinguish the action if it stops being reinforced. Popular models of learning describe extinction as the automatic outcome of a prediction-error correction process that gradually weakens, and eventually eliminates, the response-reward association. But there is much evidence that conditioned responses are not eliminated and can be quickly restored. Other evid ....Extinction and response inhibition. Humans and other animals readily learn to perform an action if it is “reinforced” by a reward and will extinguish the action if it stops being reinforced. Popular models of learning describe extinction as the automatic outcome of a prediction-error correction process that gradually weakens, and eventually eliminates, the response-reward association. But there is much evidence that conditioned responses are not eliminated and can be quickly restored. Other evidence suggests that extinction might involve more specific inhibitory processes that suppress the response without eliminating the original learning. The current project investigates the role of response inhibition in the extinction of learned responses in humans.Read moreRead less
Existing knowledge determines how new experiences are encoded in the brain. The aim of this project is to identify how existing knowledge shapes the way that new fear memories are encoded and stored in the brain. It seeks to achieve this aim through the use of an animal model, Pavlovian fear conditioning in rats. It is significant in providing the first systematic assessment of fear memories that form when dangerous experiences are consistent versus inconsistent with existing knowledge. The expe ....Existing knowledge determines how new experiences are encoded in the brain. The aim of this project is to identify how existing knowledge shapes the way that new fear memories are encoded and stored in the brain. It seeks to achieve this aim through the use of an animal model, Pavlovian fear conditioning in rats. It is significant in providing the first systematic assessment of fear memories that form when dangerous experiences are consistent versus inconsistent with existing knowledge. The expected outcomes include new information regarding the links between existing knowledge, fear memories and their neural substrates. This information is needed for the development of a comprehensive theory that explains how the conditions under which fear memories form determines their content and wiring in the brain.Read moreRead less
Punishment learning: from cells to circuits to behaviour. This project aims to ask and answer fundamental questions about how risk and danger guide our learning and behaviour. It combines theoretically driven approaches from associative learning and experimental psychology with a state of the art technology platform for mapping and manipulating brain function. This project expects to provide new mechanistic knowledge, from cells to circuits to behaviour, about how punishment shapes our learning ....Punishment learning: from cells to circuits to behaviour. This project aims to ask and answer fundamental questions about how risk and danger guide our learning and behaviour. It combines theoretically driven approaches from associative learning and experimental psychology with a state of the art technology platform for mapping and manipulating brain function. This project expects to provide new mechanistic knowledge, from cells to circuits to behaviour, about how punishment shapes our learning and behaviour. This should provide significant benefits including a new knowledge base advancing theories of associative learning as well as laying a new basic science platform for understanding how punishment contributes to learning and emotional deficits.Read moreRead less
Extinction of fears based on learned sources of danger. This project aims to advance our understanding of how fear memories are encoded and stored in the mammalian brain. It seeks to achieve this aim through the use of an animal model, second-order fear conditioning in rats. It is significant in providing the first systematic assessment of different types of fear memories, such as those that form during encounters with innate (e.g., involving suffocation or pain) or learned sources of danger (e. ....Extinction of fears based on learned sources of danger. This project aims to advance our understanding of how fear memories are encoded and stored in the mammalian brain. It seeks to achieve this aim through the use of an animal model, second-order fear conditioning in rats. It is significant in providing the first systematic assessment of different types of fear memories, such as those that form during encounters with innate (e.g., involving suffocation or pain) or learned sources of danger (e.g., being threatened with a gun). The expected outcomes include new information regarding how different types of fear memories can be controlled or inhibited. This information is needed for the development of a comprehensive theory of fear, and improved fear regulation strategies in its various disorders.Read moreRead less
How do females overcome fear? New insights from the maternal brain. This project aims to identify how the mechanisms underlying fear regulation shift as a function of pregnancy, a female-unique biological event that leads to profound and enduring changes within fear-relevant brain regions. The outcomes of this project will substantially advance current, male-based theories of fear regulation by generating new knowledge on fear regulation in females that is tailored to their reproductive status. ....How do females overcome fear? New insights from the maternal brain. This project aims to identify how the mechanisms underlying fear regulation shift as a function of pregnancy, a female-unique biological event that leads to profound and enduring changes within fear-relevant brain regions. The outcomes of this project will substantially advance current, male-based theories of fear regulation by generating new knowledge on fear regulation in females that is tailored to their reproductive status. This aligns with international priority calls to close the knowledge gap on fundamental processes in females. This new knowledge will provide a foundation to improve treatments for anxiety disorders in women, who are twice more prone to such conditions than men, particularly during the peripartum period.Read moreRead less