Plasmapheresis As A Novel Treatment Of Postural Tachycardia Syndrome: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$97,081.00
Summary
We aim to conduct a randomized controlled trial to test our hypothesis that the removal of autoantibodies (through plasmapheresis) will reduce the severity of symptoms in patients with postural tachycardia syndrome. We will be measuring symptom scores, cardiovascular fitness on exercise testing, heart rate and blood pressure responses during valsalva and orthostatic stress as well as the metabolic profiles and presence of autoantibodies in the blood of patients participating in the trial.
The Characterisation Of The Functional Regions Of Sarcomeric Alpha-actinins And To Determine How The Absence Of Alpha-actinin-3 Influences Human Skeletal Muscle Function And Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$95,313.00
Summary
We are studying a muscle protein called a-actinin-3. This protein is absent in approximately one billion people worldwide. A-actinin-3 is associated with athletic performance. Our goal is to explore how the absence of a-actinin-3 influences human skeletal muscle function and metabolism. We will be studying a-actinin-3 deficiency using a mouse model.