Regulation Of Receptors That Control Platelet Function Under Shear Stress
Funder
National Health and Medical Research Council
Funding Amount
$507,273.00
Summary
Specialized human blood cells that control blood loss and clotting (platelets) are currently difficult to test in the clinical laboratory, meaning patients are at risk of excessive bleeding or serious clot formation during disease or treatment. The aim of this proposal is to use our new reagents and assays to develop more reliable methods for evaluating relative bleeding or clotting risk in individuals.
Autoimmune-based thrombocytopenia can be a life-threatening adverse event associated with viral load, surgery, drug therapies or the use of the anticoagulant, heparin. This grant will define mechanisms of anti-platelet antibody-dependent platelet activation and assess shedding of platelet-specific glycoprotein (GP)VI as an immediate consequence of this activation, provide a new strategy for evaluating risk of thrombosis in HIT.
Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people w ....Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people with prothrombotic pathologies.Read moreRead less
The Role Of Duffy And PF4 In The Platelet Killing Of Malaria Parasites.
Funder
National Health and Medical Research Council
Funding Amount
$350,045.00
Summary
Platelets in the blood can kill the Plasmodium parasite, which lives inside red blood cells and causes malaria. Platelets bind parasite-infected red cells and release a molecule that is toxic to the parasite. This project will study why a red cell molecule called Duffy is also needed for this function of platelets. Most Africans carry a gene for Duffy that stops its expression in red cells, and may therefore be more susceptible to malaria because their platelets cannot kill the malaria parasite.
Voices of Regional Australia: The linguistic patterning of local attachment. This project aims to investigate language and social dynamics among regional Australians, who, despite representing one third of the population, have been often neglected in the research to date. The project expects to generate new knowledge around regional attachment and the impact that has on speech patterns, adapting for the first time recently developed international metrics to the Australian context. Expected outco ....Voices of Regional Australia: The linguistic patterning of local attachment. This project aims to investigate language and social dynamics among regional Australians, who, despite representing one third of the population, have been often neglected in the research to date. The project expects to generate new knowledge around regional attachment and the impact that has on speech patterns, adapting for the first time recently developed international metrics to the Australian context. Expected outcomes include a better understanding of models of language change across urban and rural areas, and a novel dataset recording the stories of regional Australians, and in particular, their experiences facing bushfire. This should provide significant benefits as a record of life, language and community in regional Australia.Read moreRead less
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
The rapid interactions of circulating human blood platelets is critical to prevent bleeding, but can cause thrombotic diseases (heart attack, stroke). These highly regulated interactions involve specific adhesive proteins. Our studies will define factors regulating platelet interactions. Imaging the thrombotic process will quantify platelet function at an unprecedented resolution and we have a panel of new candidate reagents that will be assessed for antithrombotic potential.
Languages of Barrier Islands, Sumatra: Description, History and Typology. This project aims to investigate endangered languages of the Asia-Pacific via four undocumented languages in the Barrier Islands, Indonesia. New knowledge will be generated into the languages, cultures and societies of the region on an unprecedented scale, and be made freely available to the public. New data will uncover past migration patterns in Southeast Asia, advance language theory (such as linguistic typology and lan ....Languages of Barrier Islands, Sumatra: Description, History and Typology. This project aims to investigate endangered languages of the Asia-Pacific via four undocumented languages in the Barrier Islands, Indonesia. New knowledge will be generated into the languages, cultures and societies of the region on an unprecedented scale, and be made freely available to the public. New data will uncover past migration patterns in Southeast Asia, advance language theory (such as linguistic typology and language change), and support the computational modelling of Austronesian for future language technologies. Connections with Indonesian institutions will strengthen Australia’s regional engagement, and support language revitalisation and maintenance among minority communities for the preservation of their culture and history.Read moreRead less