Investigating The Use Of Bone Marrow Transplantation To Study And Treat Polycystic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$349,250.00
Summary
Polycystic kidney disease (PKD) is a common genetic condition that causes fluid filled cysts to form in the kidney. In many cases, these cysts lead to kidney failure. Once the kidneys fail irreversibly, the only treatments available are dialysis and kidney transplantation. Dialysis to remove waste products from the blood is time consuming and does not completely replace all functions of the kidney. Kidney transplantation is limited by the availability of donor organs. At present, there are no re ....Polycystic kidney disease (PKD) is a common genetic condition that causes fluid filled cysts to form in the kidney. In many cases, these cysts lead to kidney failure. Once the kidneys fail irreversibly, the only treatments available are dialysis and kidney transplantation. Dialysis to remove waste products from the blood is time consuming and does not completely replace all functions of the kidney. Kidney transplantation is limited by the availability of donor organs. At present, there are no reliable ways to prevent the onset or slow the progression of PKD. The kidney consists of a complex system of tubules and ducts. PKD causes the cells that make up these tubules and ducts to grow uncontrollably and form cysts. We are using mice to study how mutations affect the mechanisms that control cell growth in the kidney and cause PKD. Bone marrow cells can move to the kidney and repair it after damage. We will test if bone marrow cells carrying a PKD mutation can cause PKD when transplanted into a healthy mouse. This will help us learn how mutations cause PKD in humans. We will also see if normal bone marrow can prevent disease when transplanted into a mutant mouse that spontaneously develops PKD. This experiment may lay the basis for a way to treat human PKD.Read moreRead less
Effects Of Exercise And Lifestyle Management On Reproductive Function In Overweight Women With Polycystic Ovary Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$379,719.00
Summary
Polycystic ovary syndrome (PCOS) is a complex disorder present in 5-10% of women of reproductive age. It is associated with obesity, increased menstrual dysfunction and infertility and metabolic conditions such as increased serum insulin, high cholesterol, diabetes and heart disease. Lifestyle interventions aimed at reducing obesity and insulin resistance, which include dietary weight loss and physical activity, are advocated for the management of PCOS. However, while research indicates that wei ....Polycystic ovary syndrome (PCOS) is a complex disorder present in 5-10% of women of reproductive age. It is associated with obesity, increased menstrual dysfunction and infertility and metabolic conditions such as increased serum insulin, high cholesterol, diabetes and heart disease. Lifestyle interventions aimed at reducing obesity and insulin resistance, which include dietary weight loss and physical activity, are advocated for the management of PCOS. However, while research indicates that weight loss through diet improves many symptoms, there is a paucity of research evaluating the combined role of physical exercise in managing this condition. In addition, there is no research examining the optimal form of exercise that should be undertaken to achieve long-term reproductive fitness and metabolic health and consequently there is a lack of evidence-based exercise guidelines for patients with PCOS. We plan to perform a clinical study to investigate whether combining exercise with weight loss by diet in patients with PCOS provides any additional benefit for improving menstrual function, fertility and metabolic health beyond those that can be achieved using dietary restriction alone. We will also assess whether, when combined with dietary restriction, a program of physical activity incorporating both endurance and resistance exercise provides a greater benefit than the more common prescription of endurance exercise alone. This information will be used to assist in the development of guidelines for the effective management of reproductive dysfunction in patients with PCOS.Read moreRead less
Fetal And Genetic Origins Of Polycystic Ovary Syndrome (PCOS) In Young Women
Funder
National Health and Medical Research Council
Funding Amount
$449,073.00
Summary
Polycystic ovary syndrome (PCOS) is a common hormonal condition which emerges at puberty and afflicts up to 10% of women. The cause of PCOS is uncertain. Symptoms include menstrual disorders, acne, obesity, and excess body hair. PCOS is of great significance for women because of the high incidence of infertility and the high risk of other serious diseases, including diabetes mellitus and endometrial cancer. PCOS is probably the most common hormonal condition among young women. The cause of PCOS ....Polycystic ovary syndrome (PCOS) is a common hormonal condition which emerges at puberty and afflicts up to 10% of women. The cause of PCOS is uncertain. Symptoms include menstrual disorders, acne, obesity, and excess body hair. PCOS is of great significance for women because of the high incidence of infertility and the high risk of other serious diseases, including diabetes mellitus and endometrial cancer. PCOS is probably the most common hormonal condition among young women. The cause of PCOS is unknown and the relationship between PCOS and the more common condition of polycystic ovaries, which often features in PCOS, is uncertain. There is evidence that genetic factors contribute to PCOS, but cannot explain certain aspects. There is also striking new evidence that abnormal growth in the womb can alter the metabolism of the baby for life, resulting in increased risks of adult disease, including diabetes and cardiovascular disease. PCOS may be another consequence of abnormal fetal growth, a suggestion that is supported by two recent studies of closely related conditions. To investigate the origins of PCOS, we propose to establish the first international study of the relationships between fetal growth, genetic factors and the presence of PCOS. In this study, we shall trace 3,260 women born in one maternity ward during 1973-75. These women, now young adults, will be invited into our study for an interview, physical examination, and a blood test. We expect 2,200 women will participate. Of this group, some 220 women with PCOS will receive further tests to investigate a range of metabolic problems. The study has the potential to illuminate the path from genetic predisposition and fetal growth, to the emergence of an important reproductive disorder with serious associated diseases in a woman s later life.Read moreRead less
The Fetal And Early Childhood Origins Of PCOS: A Prospective Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$499,116.00
Summary
The Polycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, which translates into around 350,000 women in Australia. It is the most common hormonal disorder in women. The syndrome has far-reaching adverse implications for general and reproductive health, including menstrual disorder, obesity, infertility, miscarriage, pregnancy complications, increased risk of diabetes and possibly heart disease. PCOS also commonly causes cosmetic problems such as excess body hair and ac ....The Polycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, which translates into around 350,000 women in Australia. It is the most common hormonal disorder in women. The syndrome has far-reaching adverse implications for general and reproductive health, including menstrual disorder, obesity, infertility, miscarriage, pregnancy complications, increased risk of diabetes and possibly heart disease. PCOS also commonly causes cosmetic problems such as excess body hair and acne. The underlying causes of PCOS are not known but are thought to arise during intrauterine (fetal) life and to be modified by aspects of childhood health, particularly overweight and obesity. Using a large and well established cohort of adolescents followed up since fetal life and throughout childhood and currently aged 13-15 years old (the Raine cohort), we will define for the first time the intrauterine and early childhood correlates of PCOS. PCOS will be diagnosed by a specialist gynacologist using current international criteria. We will then utilise extensive existing data from this cohort combined with new measurements on existing samples to determine the contribution of key factors including fetal growth restriction, low birth weight, fetal androgen exposure, rapid postnatal growth, childhood adiposity, elevated fasting glucose and insulin and age at menarche to PCOS. In this way, we will address for the first time the hypothesis that PCOS arises as a result of events during fetal life and is affected by factors during childhood. The results from these studies will improve our understanding of PCOS and eventually improve reproductive and metabolic health for a substantial population of women internationally. It is essential that these studies are conducted as soon as possible or the opportunity will be missed. Girls with persistent menstrual irregularity are likely to be commenced on hormonal treatments which will make the diagnosis of PCOS impossible.Read moreRead less
Insulin Resistance In Polycystic Ovary Syndrome And The Role Of Skeletal Muscle And Adipose Tissue
Funder
National Health and Medical Research Council
Funding Amount
$416,115.00
Summary
11% of women have polycystic ovarian syndrome(PCOS), characterised by insulin resistance, irregular periods and infertility. These women are prone to obesity, diabetes and potentially, heart disease. Treatments include lifestyle modifications +-- medical therapy. Lifestyle is first line, yet the best diet-exercise prescription is unclear. This study will provide insights into the cause of PCOS, will inform on the role of exercise in therapy and may identify targets for future therapies.
Breastfeeding In Women With Polycystic Ovarian Syndrome, Gestational Diabetes, And Pre-existing Diabetes: Hormonal Physiology, Breastmilk Composition, Epidemiology And Patient Factors
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Polycystic ovary syndrome and diabetes (pre-existing or gestational) are important conditions in pregnant women. I intend to explore (through major literature reviews and original research) how they influence the production and composition of breastmilk, how this differs from women without the conditions, and impacts on infant health. I also aim to examine reasons for lactation difficulties in these women, both from a hormonal (basic science) perspective and at a broader (population) level.
Centre For Research Excellence In The Evaluation, Management And Health Care Needs Of Polycystic Ovary Syndrome And Related Health Implications
Funder
National Health and Medical Research Council
Funding Amount
$2,595,120.00
Summary
Polycystic Ovary Syndrome is a common condition with major health impacts, affecting one in five young Australian and one in four Indigenous women. This condition has reproductive, metabolic and emotional implications including obesity, infertility, diabetes and poor quality of life. This CRE will bring together a team of collaborative research and translation experts to improve diagnosis, capture vital prevention opportunities, optimise management and improve quality of life.
Polycystic ovary syndrome (PCOS) affects a striking 9-21% of women of reproductive age. PCOS is an important health problem and can affect menstrual cycles, fertility and increase risk of diabetes and mood disorders. There is a lack of longitudinal studies that women with PCOS over time to examine the key determinants of PCOS, long-term impact of obesity and factors contributing to PCOS complications.