Exploitation of unusual patterns of reactivity of peptides towards radicals. Life depends on free radical reactions of peptides and proteins but, for these compounds to exist, these must be inherently resistant to radicals. This project aims to combine state-of-the-art experiment and theoretical computations to build a detailed picture of peptide and protein radical reactivity, in order to explain this paradox and resolve ambiguities regarding processes through which radical damage to peptides o ....Exploitation of unusual patterns of reactivity of peptides towards radicals. Life depends on free radical reactions of peptides and proteins but, for these compounds to exist, these must be inherently resistant to radicals. This project aims to combine state-of-the-art experiment and theoretical computations to build a detailed picture of peptide and protein radical reactivity, in order to explain this paradox and resolve ambiguities regarding processes through which radical damage to peptides occurs and is repaired. The project also aims to critically evaluate the basic concept of the fidelity of amino acid incorporation during protein biosynthesis. The results of this project could underpin the development of new strategies and therapeutics to treat human diseases, and new materials and synthetic methods to increase the utility of peptides in biotechnology.Read moreRead less
Accurate gas-surface chemistry from first principles. Many aspects of gas-surface chemistry remain unexplained, despite around 90% of industrial chemical production relying on heterogeneous catalysis. A major problem is that common simulation methods used to study gas-surface chemistry do not adequately incorporate the effect of the motion of the atoms in the solid catalyst surface, preventing accurate study of surface temperature and vibrational energy transfer effects. This project aims to de ....Accurate gas-surface chemistry from first principles. Many aspects of gas-surface chemistry remain unexplained, despite around 90% of industrial chemical production relying on heterogeneous catalysis. A major problem is that common simulation methods used to study gas-surface chemistry do not adequately incorporate the effect of the motion of the atoms in the solid catalyst surface, preventing accurate study of surface temperature and vibrational energy transfer effects. This project aims to develop methods to incorporate surface atom motion in realistic atomistic simulations of gas-surface interactions. The unexplained physics and chemistry of industrially-important catalysis will be investigated. A better understanding of the physics and chemistry of molecules reacting on catalytic surfaces has the potential to allow for improved industrial production, new functional coatings on materials and, for example, enhanced engineering of corrosion resistance.Read moreRead less
Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-po ....Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-powered logistics vehicles are a major contributor. However, converting these trucks to LNG requires strong evidence to convince logistics companies of the benefits of shifting to green logistics. An increase in logistics productivity is expected to increase Australia’s gross domestic product by $2 billion, while this research should also provide vital data on sustainability issues and LNG conversions.Read moreRead less
Accurate and fast quantum simulation to predict chemistry. Quantum mechanical simulation is the most accurate tool available for predicting and understanding chemical reactions. Traditional techniques for performing quantum mechanical simulations of molecular collisions and reactions cannot be applied to more than five or six atoms, meaning that it is not possible to study most chemical reactions in full detail. In this project a new technique for performing these accurate simulations, recently ....Accurate and fast quantum simulation to predict chemistry. Quantum mechanical simulation is the most accurate tool available for predicting and understanding chemical reactions. Traditional techniques for performing quantum mechanical simulations of molecular collisions and reactions cannot be applied to more than five or six atoms, meaning that it is not possible to study most chemical reactions in full detail. In this project a new technique for performing these accurate simulations, recently invented at the Australian National University and allowing the study of much larger systems, will be developed and applied to important outstanding problems in chemical dynamics, ranging from roaming in formaldehyde to atom migration in proteins.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100032
Funder
Australian Research Council
Funding Amount
$2,119,872.00
Summary
ARC Training Centre for Food and Beverage Supply Chain Optimisation. ARC Training Centre for Food and Beverage Supply Chain Optimisation. With 15 per cent of the Australian workforce involved in food production and annual food exports of $30.5 billion, the food industry is clearly vital to the Australian economy. The National Food Plan White Paper states as a goal for 2025: "The value of Australia's agriculture and food-related exports will have increased by 45 per cent (in real terms), contribu ....ARC Training Centre for Food and Beverage Supply Chain Optimisation. ARC Training Centre for Food and Beverage Supply Chain Optimisation. With 15 per cent of the Australian workforce involved in food production and annual food exports of $30.5 billion, the food industry is clearly vital to the Australian economy. The National Food Plan White Paper states as a goal for 2025: "The value of Australia's agriculture and food-related exports will have increased by 45 per cent (in real terms), contributing to an increase in our gross domestic product." To make these aspirations a reality, safe, sustainable, and cost-effective, food supply chains will be essential. The Training Centre will train the next generation of multi-disciplinary researchers capable of designing and managing these supply chains.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Mathematics and computing for integrated stockyard-centric management of mining supply chains. Blended mineral products, such as coal and iron ore, make a strong contribution to Australia's economy. Blending occurs in stockpiles, so to realise product value, stockyard and supply chain operational plans must align with blend targets. This project will provide new mathematical and computational planning tools to maximise this value.