Optimising Men’s Uptake Of FIT Screening For Bowel Cancer: A Population Based Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$552,522.00
Summary
Men are more likely to die from bowel cancer but are not participating in the National Bowel Cancer Screening program to the same extent as women. The research group has devised simple messages that their previous research shows encourages men to use the screening kit. The team will compare the use of kits among men who get the Government’s usual invitations, with a group who receive invitations with the messages for men.
A Multi-component Intervention For Smoking Cessation Among Australian Male Prison Inmates
Funder
National Health and Medical Research Council
Funding Amount
$551,500.00
Summary
The prevalence of smoking amongst the Australian prison population is much higher than that in the general community. Despite a perception that prison inmates are unlikely to give up smoking while in prison, a recent survey has found that many inmates have attempted to quit or have reduced the amount they smoke. The same survey reported that almost a quarter of male inmates were planning to give up smoking within the next three months. Depression and anxiety are common among prison inmates. Rese ....The prevalence of smoking amongst the Australian prison population is much higher than that in the general community. Despite a perception that prison inmates are unlikely to give up smoking while in prison, a recent survey has found that many inmates have attempted to quit or have reduced the amount they smoke. The same survey reported that almost a quarter of male inmates were planning to give up smoking within the next three months. Depression and anxiety are common among prison inmates. Research has shown that people with depression or anxiety problems are less likely to quit, and more likely to relapse, than smokers without these symptoms. For this reason there has been interest in incorporating antidepressant medications into quit strategies. As a group with a high prevalence of depression and anxiety, prisoners may benefit from an intervention strategy that includes an antidepressant medication. Prisoners are often poorly educated, on a low income or benefits, or from a lower socioeconomic or an indigenous background. Members of this disadvantaged group have been shown to be less likely to use preventive health services, such as smoking cessation programs. This research proposal represents the first large scale randomised controlled trial of a multi-component intervention for tobacco dependence amongst a prisoner population in the world. This project will compare the effectiveness of adding an antidepressant medication to counselling, nicotine replacement therapy, a coping with change package and referral to a Quitline. The proposed research follows a small pilot study of the feasibility of a similar intervention. It brings together the expertise of several people across Australia with experience in tobacco dependence and prison research. The results will inform future smoking interventions for prison inmates and offers a real opportunity to impact upon the health and well-being of some of the most marginalised groups in Australian society.Read moreRead less
The D-Health Trial: A Large-scale Population-based Trial Of Vitamin D Supplementation For Improving The Health Of Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$2,591,860.00
Summary
The D-Health Trial is a randomised placebo-controlled trial of vitamin D supplementation for improving the health of older Australian adults. Over 21,000 people were recruited and randomised to monthly doses of vitamin D or placebo. This grant will enable completion of the planned 5 years of supplementation and long-term follow-up of mortality and cancer. The results of the trial will inform decisions about food fortification and/or supplementation with vitamin D.
VITATOPS - A Randomised Controlled Trial Of Vitamins To Prevent Stroke
Funder
National Health and Medical Research Council
Funding Amount
$391,364.00
Summary
A high level of a normal protein component in the blood (homocysteine) is fast becoming recognised as a new risk factor for premature stroke and heart disease, although it remains uncertain whether treatment with vitamins can prevent these diseases from occurring. VITATOPS is a multi-centre, double-blind, placebo-controlled trial designed to examine the efficacy and safety of multi-vitamin therapy (folate, B6 and B12) in the prevention of stroke and other types of vascular disease. The VITATOPS ....A high level of a normal protein component in the blood (homocysteine) is fast becoming recognised as a new risk factor for premature stroke and heart disease, although it remains uncertain whether treatment with vitamins can prevent these diseases from occurring. VITATOPS is a multi-centre, double-blind, placebo-controlled trial designed to examine the efficacy and safety of multi-vitamin therapy (folate, B6 and B12) in the prevention of stroke and other types of vascular disease. The VITATOPS study arises from a large body of consistent, biologically plausible evidence linking homocysteine in a dose-dependent fashion to stroke and other types of vascular disease. A simple, non-toxic, and inexpensive intervention in the form of multivitamins (folate, B6 and B12) has been shown to be highly effective at reducing homocysteine levels, irrespective of the underlying cause. All patients who are referred to a neurologist or general physician in one of the collaborating centres within six months of a stroke or transient ischaemic attack are eligible for the trial. In total, treatment will continue for a period of between 1 and 5 years. During this time, patients will be closely monitored in order to record the occurrence of any vascular events (particularly strokes and heart attacks). Neither the study investigator nor the patient will know which treatment they are receiving (i.e. it is 'double blind'). The number of vascular events in the treatment groups will be compared at the end of the study in order to determine whether vitamin treatment is beneficial. This application is for five years of support to allow the investigators to move from the pilot phase of VITATOPS in Perth to begin recruitment to the definitive trial in other centres across Australia and New Zealand. This study may have a major impact on patient management. If vitamins prove to be effective, we may recommend vitamin supplementation to all of our stroke patients in the future.Read moreRead less
Chronic Disease Prevention In Priority Populations Via Scalable Health Behaviour Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Globally the burden of chronic disease is enormous. Smoking, risky alcohol use, inadequate fruit and vegetable intake and physical inactivity are modifiable risk factors of chronic conditions. This fellowship aims to prevent chronic diseases in priority populations who have poorer health outcomes including disadvantaged groups, those living in regional and remote areas and people born overseas by implementing and evaluating scalable health behaviour interventions to improve health outcomes.
Towards Global Control Of Scabies: Advances In Diagnosis, Treatment And Community Control
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
The scabies mite causes severe itch and rash and leads to infections, kidney and heart disease. Scabies affects up to 50% of children in Indigenous communities. We now know most scabies can be prevented, so we urgently need to find the most effective strategies. My research will develop new tests to help doctors to accurately diagnose scabies. I will test new medicines to treat scabies and strategies to prevent scabies and its complications in children, families and entire populations.
Point-of-care HPV-DNA Testing For Cervical Cancer Screening In High-burden, Low-resource Settings
Funder
National Health and Medical Research Council
Funding Amount
$891,184.00
Summary
We will undertake the first field evaluation of a novel, newly-available, easy to use, and highly accurate point-of-care (POC) test for high-risk human papillomavirus (hrHPV) infection that will allow trained health staff to identify women at increased risk of cervical cancer and to provide same-day cervical cryotherapy for pre-cancer lesions identified on clinical examination.
Preventing Postnatal Depression In New Mothers Using Telephone Peer Support: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$850,069.00
Summary
Depression in recent mothers are very common; more than 53,000 new mothers in Australia are affected by this each year. The condition can lead to serious adverse consequences for a mother’s health and the health of her infant and family. Effective strategies to prevent and reduce maternal depression are therefore needed. We will test whether support by telephone from other mothers (peer volunteers) helps in women at increased risk at 4 weeks postpartum.
Treatment Of Asymptomatic Candidiasis In Pregnant Women For The Prevention Of Preterm Birth: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,714,148.00
Summary
Prevention of early birth is a global priority. This study will establish if a simple process of screening and treating asymptomatic thrush in pregnancy prevents early birth. If positive the results of this study will change pregnancy management across the world to ensure a healthier start to life.