Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
Establishing genetic guidelines for the effective ecological restoration of seagrass meadows. Industry and coastal development in Australia are of national importance for economic growth and prosperity, but they threaten benthic habitats, like seagrasses. Loss of seagrass meadows without mitigation results in greater coastal impacts from damaging storms and waves and a reduction in the health and productivity of marine environments globally. Thus the ecological restoration of seagrass meadows is ....Establishing genetic guidelines for the effective ecological restoration of seagrass meadows. Industry and coastal development in Australia are of national importance for economic growth and prosperity, but they threaten benthic habitats, like seagrasses. Loss of seagrass meadows without mitigation results in greater coastal impacts from damaging storms and waves and a reduction in the health and productivity of marine environments globally. Thus the ecological restoration of seagrass meadows is an urgent national priority action that involves industry, government and the community. Through the detailed assessment of population genetic variation and key population processes in seagrasses, this project will establish genetic guidelines for a more effective seagrass restoration industry.Read moreRead less
Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understan ....Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understanding of how decision-making evolves in healthy ageing, and a tool based on genetic scores and computational modelling to predict an individual's trajectory of cognitive function. This could help identify individuals who are at risk for cognitive decline, which could then inform better interventions.Read moreRead less
Fisheries genomics of snapper in Australia and New Zealand Waters. This industry-driven project aims to assemble a strategic research alliance to generate and apply knowledge to a highly significant fisheries resource. It involves collaboration between the five major state government fisheries agencies in Australia, the New Zealand’s Crown Research Institute for seafood and two Australian labs with leadership in fish genetics and genomics. It expects to generate and integrate genomic, environmen ....Fisheries genomics of snapper in Australia and New Zealand Waters. This industry-driven project aims to assemble a strategic research alliance to generate and apply knowledge to a highly significant fisheries resource. It involves collaboration between the five major state government fisheries agencies in Australia, the New Zealand’s Crown Research Institute for seafood and two Australian labs with leadership in fish genetics and genomics. It expects to generate and integrate genomic, environmental and phenotypic datasets for snapper populations from across vast coastal regions of the two countries. The outcomes should substantially enhance intra- and inter-jurisdictional fisheries management and aquaculture initiatives, providing commercial, social and environmental benefits for many stakeholders.Read moreRead less
Rediscovering Aboriginal dispersal pathways. This project aims to use cutting-edge and transdisciplinary tools in partnership with Aboriginal people to rediscover deliberate prehistoric plant dispersal pathways along the Australian east coast. By working on three unrelated species with similar disjunct distributions, expected outcomes include detecting significant ‘cultural’ vegetation patterns that will challenge current assumptions about 'natural' plant distributions. New associations between ....Rediscovering Aboriginal dispersal pathways. This project aims to use cutting-edge and transdisciplinary tools in partnership with Aboriginal people to rediscover deliberate prehistoric plant dispersal pathways along the Australian east coast. By working on three unrelated species with similar disjunct distributions, expected outcomes include detecting significant ‘cultural’ vegetation patterns that will challenge current assumptions about 'natural' plant distributions. New associations between plant biogeography and deliberate Aboriginal manipulation of Australian environments will benefit cultural heritage, land management and restoration initiatives.Read moreRead less
Developing biogeographic know-how: Improving species divergence and dispersal estimations to examine geological and climatic evolutionary drivers. Anthropogenic activity over the last 150 years is now dramatically changing our global climate and ecosystems. The impact on biodiversity is already evident, and large-scale floral and faunal extinctions are predicted. This study unites a cohort of international experts in an interdisciplinary team to develop new molecular and mathematical methods to ....Developing biogeographic know-how: Improving species divergence and dispersal estimations to examine geological and climatic evolutionary drivers. Anthropogenic activity over the last 150 years is now dramatically changing our global climate and ecosystems. The impact on biodiversity is already evident, and large-scale floral and faunal extinctions are predicted. This study unites a cohort of international experts in an interdisciplinary team to develop new molecular and mathematical methods to expand our fundamental knowledge on how geological and global climate change have affected our world's species components and ecosystems in the past. This research is of environmental significance and global importance as it will improve our ability to predict how species behave under future predicted climate scenarios.Read moreRead less
Contemporary and retrospective genomic analyses of tiger and white sharks. This project aims to elucidate population structure and spatiotemporal changes in population distribution of tiger and white sharks; estimate the effective number of individuals across populations; and investigate signatures of adaptive evolution in tiger- and white shark populations in response to exploitation and global change. It will perform high-resolution retrospective genomic analyses using DNA extracted from conte ....Contemporary and retrospective genomic analyses of tiger and white sharks. This project aims to elucidate population structure and spatiotemporal changes in population distribution of tiger and white sharks; estimate the effective number of individuals across populations; and investigate signatures of adaptive evolution in tiger- and white shark populations in response to exploitation and global change. It will perform high-resolution retrospective genomic analyses using DNA extracted from contemporary and archival tiger and white shark skeletal material held in museum and trophy collections around the world. This project expects to gain valuable insight into the biology of both species and provide information for conservation and management purposes.Read moreRead less
Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect ....Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect productivity, enhance predictive capability, and initiate advanced breeding strategies to develop new crop varieties with superior resilience against changing climates. This should provide significant benefits, such as profit stability for wheat growers, elevated global market position and improved food security.Read moreRead less
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the forma ....Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the formation of this essential vertebrate tissue. Ultimately, this is expected to provide new knowledge in stem and precursor cell differentiation, the evolution of complex organ systems and tissue formation. Outcomes may impact on future biotechnology in the areas of tissues engineering, stem cell differentiation and regeneration.Read moreRead less